Small, EarlyView.Synthetic high‐density lipoprotein (sHDL) nanodiscs are developed to co‐deliver liver‐X‐Receptor (LXR) agonists and Toll‐like receptor 9 (TLR‐9) agonist CpG for glioma treatment. By upregulation of ATP‐binding cassette transporter A1 (ABCA1), LXR agonists synergize with sHDL nanodiscs to deplete cholesterol and induce apoptosis of glioma cells.
Troy A. Halseth +12 more
wiley +1 more source
Imaging the orientation of myelin sheaths in a non-stained histology slide of human brain [PDF]
, 2020 G. V. Schulz +4 more
openalex +1 more source
Robust Spatial Cell‐Type Deconvolution with Qualitative Reference for Spatial Transcriptomics
Small Methods, EarlyView.QR‐SIDE is a robust method to integrate cell‐type deconvolution and domain detection for spatial transcriptomics. By leveraging marker genes and spatial information, it uncovers tissue architecture and cell‐type compositions. Its adaptive modeling ensures resilience to noisy markers, and its flexibility supports applications across resolutions ...
Qishi Dong +5 more
wiley +1 more source
Connexin32 and X-linked Charcot–Marie–Tooth Disease
Neurobiology of Disease, 1997 Mutations in the gap junction geneconnexin32(Cx32) cause the X-linked form of Charcot–Marie–Tooth disease, an inherited demyelinating neuropathy. More than 130 different mutations have been described, affecting all portions of the Cx32 protein.
Linda Jo Bone +4 more
doaj
Myelin sheath and cyanobacterial thylakoids as concentric multilamellar structures with similar bioenergetic properties. [PDF]
Open Biol, 2021 Morelli AM +4 more
europepmc +1 more source
P4–288: Influence of GETO extract on myelin sheath structure and myelin basic protein content in the brain with AD model [PDF]
, 2006 Jing Shi +5 more
openalex +1 more source
Conductive Hydrogel‐Based Neural Interfaces: From Fabrication Methods, Properties, to Applications
Small Structures, EarlyView.This review summarizes the fabrication methods, properties, and applications of conductive hydrogels in neural interfaces. Finally, the prevailing challenges and outlines of future directions in the field of conductive hydrogels for neural interfaces are provided, emphasizing the need for interdisciplinary research to address issues such as long‐term ...
Xin‐Yu Xue +10 more
wiley +1 more source
Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNS [PDF]
, 2006 Tina Buerki‐Thurnherr +9 more
openalex +1 more source
6 4 Integrin and Dystroglycan Cooperate to Stabilize the Myelin Sheath [PDF]
, 2008 Alessandro Nodari +12 more
openalex +1 more source
Cognitive Computation and Systems, EarlyView.Abstract Accurate magnetic resonance imaging (MRI) segmentation plays a critical role in the diagnosis and treatment of demyelinating diseases. But the existing automatic segmentation methods are not suitable for the segmentation of demyelinating lesions with small lesion size, highly diffuse edges and complex boundary shapes.
Minhui Liu +4 more
wiley +1 more source