Microglia phagocytose myelin sheaths to modify developmental myelination [PDF]
Nature Neuroscience, 2020 During development, oligodendrocytes contact and wrap neuronal axons with myelin. Similarly to neurons and synapses, excess myelin sheaths are produced and selectively eliminated, but how elimination occurs is unknown. Microglia, the resident immune cells of the central nervous system, engulf surplus neurons and synapses. To determine whether microglia
Alexandria N Hughes, Bruce Appel
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Treadmilling Model for Plasticity of the Myelin Sheath. [PDF]
Trends Neurosci, 2019 We propose a mechanism for myelin plasticity that would complement synaptic plasticity by adjusting conduction velocity for optimal spike-time arrival. In the proposed treadmilling model, myelin sheath thickness is a dynamic balance between the rates of new myelin deposited adjacent to the axon and removal of the outermost layer.
Fields RD, Dutta DJ.
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Frontiers in PhysicsIntroductionQuantifying the myelin sheath radius of myelinated axons in vivo is important for understanding, diagnosing, and monitoring various neurological disorders.
Erick J. Canales-Rodríguez +13 more
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Shielding effects of myelin sheath on axolemma depolarization under transverse electric field stimulation [PDF]
PeerJ, 2018 Axonal stimulation with electric currents is an effective method for controlling neural activity. An electric field parallel to the axon is widely accepted as the predominant component in the activation of an axon.
Hui Ye, Jeffrey Ng
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Entangled biphoton generation in the myelin sheath
Physical Review EConsciousness within the brain hinges on the synchronized activities of millions of neurons, but the mechanism responsible for orchestrating such synchronization remains elusive. In this study, we employ cavity quantum electrodynamics (cQED) to explore entangled biphoton generation through cascade emission in the vibration spectrum of C-H bonds within ...
Zefei Liu, Yong-Cong Chen, Ping Ao
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Role of Connexin-Based Gap Junction Channels in Communication of Myelin Sheath in Schwann Cells [PDF]
Frontiers in Cellular Neuroscience, 2019 Peripheral nerves have the capacity to conduct action potentials along great distances and quickly recover following damage which is mainly due to Schwann cells (SCs), the most abundant glial cells of the peripheral nervous system (PNS).
Bruno A. Cisterna +3 more
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Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death. [PDF]
Cell Rep, 2022 Aber ER +9 more
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A new diagnostic sampling method in pure neural leprosy: the scraping of the myelin sheath. [PDF]
An Bras Dermatol, 2021 Trave I +3 more
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FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system [PDF]
Nature CommunicationsMyelin, along with the oligodendrocytes (OLs) that produce it, is essential for proper central nervous system (CNS) function in vertebrates. Although the accurate targeting of myelin to axons and its maintenance are critical for CNS performance, the ...
Hannah Y. Collins +8 more
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Aerobic exercise attenuates abnormal myelination and oligodendrocyte differentiation in 3xTg-AD mice
Experimental Gerontology, 2023 Pathological features of Alzheimer's Disease (AD) include alterations in the structure and function of neurons as well as of myelin sheaths. Accumulated evidence shows that aerobic type of exercise can enhance neuroplasticity in mouse models of AD ...
Dan Qiu +4 more
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