Treadmilling Model for Plasticity of the Myelin Sheath. [PDF]
Trends Neurosci, 2019 We propose a mechanism for myelin plasticity that would complement synaptic plasticity by adjusting conduction velocity for optimal spike-time arrival. In the proposed treadmilling model, myelin sheath thickness is a dynamic balance between the rates of new myelin deposited adjacent to the axon and removal of the outermost layer.
Fields RD, Dutta DJ.
europepmc +5 more sources
Cdc42 regulates schwann cell radial sorting and myelin sheath folding through NF2/merlin‐dependent and independent signaling [PDF]
Glia, 2013 The Rho family GTPase Cdc42 has been implicated in developmental Schwann cell (SC) proliferation, providing sufficient SCs for radial sorting of axons preceding SC differentiation in the peripheral nervous system. We generated Cdc42 conditional knockout (
Li Guo +3 more
semanticscholar +2 more sources
Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS. [PDF]
J Neurosci, 2016 The signaling pathways that regulate myelination in the PNS remain poorly understood. Phosphatidylinositol-4,5-bisphosphate 3-kinase 1A, activated in Schwann cells by neuregulin and the extracellular matrix, has an essential role in the early events of ...
Domènech-Estévez E +8 more
europepmc +2 more sources
Shielding effects of myelin sheath on axolemma depolarization under transverse electric field stimulation [PDF]
PeerJ, 2018 Axonal stimulation with electric currents is an effective method for controlling neural activity. An electric field parallel to the axon is widely accepted as the predominant component in the activation of an axon.
Hui Ye, Jeffrey Ng
doaj +3 more sources
A myelin sheath protein forming its lattice. [PDF]
J Biol Chem, 2020 The formation of a mature, multilayered myelin sheath requires the compaction of lipid bilayers, but the molecular mechanism by which these bilayers condense is an open question. In this issue, Ruskamo et al. find that peripheral myelin protein P2 forms an ordered three-dimensional lattice within model membranes using Escherichia coli polar lipid ...
Tsuge H.
europepmc +5 more sources
Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death. [PDF]
Cell Rep, 2022 Aber ER +9 more
europepmc +3 more sources
Role of myelin sheath energy metabolism in neurodegenerative diseases.
Neural Regen Res, 2015 More than any other organs, brain energy demand is entirely dependent on glucose catabolism through the oxidative phosphorylation (OXPHOS). Glucose is the major cerebral energy substrate in the nervous system (NS).
Ravera S, Panfoli I.
europepmc +2 more sources
A new diagnostic sampling method in pure neural leprosy: the scraping of the myelin sheath. [PDF]
An Bras Dermatol, 2021 Trave I +3 more
europepmc +2 more sources
Role of Connexin-Based Gap Junction Channels in Communication of Myelin Sheath in Schwann Cells [PDF]
Frontiers in Cellular Neuroscience, 2019 Peripheral nerves have the capacity to conduct action potentials along great distances and quickly recover following damage which is mainly due to Schwann cells (SCs), the most abundant glial cells of the peripheral nervous system (PNS).
Bruno A. Cisterna +3 more
doaj +2 more sources
Ndrg1 in development and maintenance of the myelin sheath
Neurobiology of Disease, 2011 CMT4D disease is a severe autosomal recessive demyelinating neuropathy with extensive axonal loss leading to early disability, caused by mutations in the N-myc downstream regulated gene 1 (NDRG1). NDRG1 is expressed at particularly high levels in the Schwann cell (SC), but its physiological function(s) are unknown.
Toshiyuki Miyata +14 more
openaire +5 more sources