Results 61 to 70 of about 72,448 (306)

Myelin-Associated Glycoprotein Is a Myelin Signal that Modulates the Caliber of Myelinated Axons [PDF]

The Journal of Neuroscience, 1998
Myelination increases neuronal conduction velocity through its insulating properties and an unidentified extrinsic effect that increases axonal caliber. Although it is well established that demyelination can cause axonal atrophy, the myelin molecule that regulates axonal caliber is not known.
X, Yin, T O, Crawford, J W, Griffin, P h, Tu, V M, Lee, C, Li, J, Roder, B D, Trapp   +7 more
openaire   +2 more sources

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Supplementation with complex milk lipids during brain development promotes neuroplasticity without altering myelination or vascular density

Food & Nutrition Research, 2015
Background: Supplementation with complex milk lipids (CML) during postnatal brain development has been shown to improve spatial reference learning in rats.
Rosamond B. Guillermo, Panzao Yang, Mark H. Vickers, Paul McJarrow, Jian Guan   +4 more
doaj   +1 more source

Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis

eLife, 2021
Myelination depends on timely, precise control of oligodendrocyte differentiation and myelinogenesis. Cholesterol is the most abundant component of myelin and essential for myelin membrane assembly in the central nervous system.
Xin Zhou, Seula Shin, Chenxi He, Qiang Zhang, Matthew N Rasband, Jiangong Ren, Congxin Dai, Rocío I Zorrilla-Veloz, Takashi Shingu, Liang Yuan, Yunfei Wang, Yiwen Chen, Fei Lan, Jian Hu   +13 more
doaj   +1 more source

Schwann cell myelination requires Dynein function [PDF]

, 2012
Background Interaction of Schwann cells with axons triggers signal transduction that drives expression of Pou3f1 and Egr2 transcription factors, which in turn promote myelination.
Appel Bruce, Langworthy Melissa M
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Dietary Iron Repletion following Early-Life Dietary Iron Deficiency Does Not Correct Regional Volumetric or Diffusion Tensor Changes in the Developing Pig Brain

Frontiers in Neurology, 2018
BackgroundIron deficiency is the most common micronutrient deficiency worldwide and children are at an increased risk due to the rapid growth occurring during early life.
Austin T. Mudd, Austin T. Mudd, Joanne E. Fil, Joanne E. Fil, Laura C. Knight, Laura C. Knight, Ryan N. Dilger, Ryan N. Dilger, Ryan N. Dilger, Ryan N. Dilger, Ryan N. Dilger   +10 more
doaj   +1 more source

Microfiber platform for oligodendrocyte myelination

, 2019
Injuries or disorders in the central nervous system disrupt crucial sensory and motor functions. This critical system has limited regenerative capability, often contributes directly to permanent disabilities in afflicted adults.
Ong, William
core   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination

Frontiers in Cellular Neuroscience, 2019
Neuropathic pain caused by nerve injury or disease remains a major challenge for modern medicine worldwide. Most of the pathogenic mechanisms underlying neuropathic pain are centered on neuronal mechanisms.
Zhongya Wei, Ying Fei, Wenfeng Su, Gang Chen, Gang Chen   +4 more
doaj   +1 more source