Results 1 to 10 of about 1,098 (144)
Proteases and Protease Inhibitors of Urinary Extracellular Vesicles in Diabetic Nephropathy [PDF]
Journal of Diabetes Research, 2015 Diabetic nephropathy (DN) is one of the major complications of diabetes mellitus (DM), leads to chronic kidney disease (CKD), and, ultimately, is the main cause for end-stage kidney disease (ESKD).
Luca Musante +6 more
doaj +7 more sources
Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells [PDF]
Proceedings of the National Academy of Sciences, 2000 Hematopoiesis depends on a pool of quiescent hematopoietic stem/progenitor cells. When exposed to specific cytokines, a portion of these cells enters the cell cycle to generate an amplified progeny. Myeloblastin (MBN) initially was described as involved in proliferation of human leukemia cells.
Pierre G. Lutz +5 more
core +6 more sources
pH-dependent hysteretic behaviour of human myeloblastin (leucocyte proteinase 3) [PDF]
Biochemical Journal, 1996 Human myeloblastin (leucocyte proteinase 3) showed a very slow approach to the steady-state velocity when the pH was rapidly increased from 3.2 to 7.0. The kinetic mechanism of this hysteretic process was interpreted as a slow conformational change of myeloblastin from an inactive form at acidic pH to the active form at neutral pH.
Antonio Baici +3 more
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Regulation of myeloblastin messenger RNA expression in myeloid leukemia cells treated with all-trans retinoic acid [PDF]
Blood, 1993 Abstract Retinoic acid is known to induce differentiation of human myeloid leukemia cells in vitro. Recently, all-trans retinoic acid has been used to induce remissions in patients with acute promyelocytic leukemia, probably through differentiation of the leukemia cells.
Catherine Labbaye +6 more
+6 more sources
Proteolytic Degradation Is a Major Contributor to Bioprosthetic Heart Valve Failure [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Whereas the risk factors for structural valve degeneration (SVD) of glutaraldehyde‐treated bioprosthetic heart valves (BHVs) are well studied, those responsible for the failure of BHVs fixed with alternative next‐generation chemicals remain ...
Alexander E. Kostyunin +16 more
doaj +2 more sources
Wegener autoantigen and myeloblastin are encoded by a single mRNA. [PDF]
Proceedings of the National Academy of Sciences, 1991 Myeloblastin is a serine protease that has been identified in the human leukemia cell line HL-60. Down-regulation of this protease can inhibit proliferation and induce differentiation of promyelocyte-like human leukemic cells. Proteinase 3, a serine protease of human neutrophils, has been identified as the Wegener autoantigen.
Catherine Labbaye +2 more
openalex +3 more sources
Cell, 1989 Cells from the human leukemia cell line HL-60 undergo terminal differentiation when exposed to inducing agents. Differentiation of these cells is always accompanied by withdrawal from the cell cycle. Here we describe the isolation of a cDNA encoding a novel serine protease that is present in HL-60 cells and is down-regulated during induced ...
Dominique Bories +4 more
openalex +3 more sources
Myeloblastin is an Myb target gene: mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid [PDF]
Blood, 2001 AbstractA pivotal role has been assigned to Myb in the control of myeloid cell growth. Although Myb is a target of retinoic acid, little is known about the mechanisms by which it may contribute to induced growth arrest in leukemia cells. Indeed, few Myb target genes are known to be linked to proliferation.
Pierre G. Lutz +3 more
openalex +4 more sources
Interferon-α, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia [PDF]
Blood, 2002 AbstractChronic myeloid leukemia (CML) is a clonal disease of hematopoietic stem cells caused by a reciprocal translocation of the long arms of chromosomes 9 and 22. In human leukocyte antigen A*0201+ (HLA-A*0201+) individuals, response after interferon-α (IFN-α) was shown to be associated with the emergence of CML-specific cytotoxic T cells that ...
Andreas Burchert +14 more
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Biological Chemistry Hoppe-Seyler, 1996 Human myeloblastin (leukocyte proteinase 3) shares many biochemical properties with leukocyte elastase, but rapidly loses enzymatic activity when raising the pH and/or the ionic strength of an acidic solution or when handled in glass vessels. This poses limits to kinetic experiments requiring long incubation times.
Hans FRÜH +3 more
openalex +3 more sources