Modic type 2 changes are fibroinflammatory changes with complement system involvement adjacent to degenerated vertebral endplates [PDF]
JOR SPINE, Volume 6, Issue 1, March 2023., 2022 Background Vertebral endplate signal intensity changes visualized by magnetic resonance imaging termed Modic changes (MC) are highly prevalent in low back pain patients.
Aradi‐Vegh, Borbala +15 more
core +2 more sources
KRAS Mutation Is Associated With Elevated Myeloblastin Activity In Human Lung Adenocarcinoma
Cancer genomics & proteomics, 2012 Lung cancer is the leading cause of all cancer deaths worldwide with suboptimal prognosis and treatment options. Therefore this study aimed to identify molecular characteristics with a predictive clinical utility which at the same time might represent novel therapeutic targets for human lung adenocarcinoma.
Sven Hillinger +7 more
+6 more sources
Cytosine demethylation of the proteinase-3/myeloblastin primary granule protease gene during phagocyte development [PDF]
Leukemia, 1999 Proteinase-3/Myeloblastin (Mbn) is a neutral serine protease and a major constituent of the primary granules of myeloid cells. It can degrade extracellular matrix proteins and has been discussed as a key factor for the initiation of terminal differentiation in promyelocytic cells.
Michael Lübbert +2 more
openalex +4 more sources
MCF‐7 mammary tumour cells express the myeloid cell differentiation controlling factor, serine protease3/myeloblastin [PDF]
Cell Proliferation, 2000 Our previous data indicated that HSP27 plays a role in MCF‐7 cell differentiation similar to that it has in HL‐60 cells. In the latter case, this involves a control of its levels by proteinase 3/myeloblastin (PR3/Mbn), a serine proteinase hitherto considered specific of the myeloid lineage.
Sandrine Horman +2 more
openalex +3 more sources
Identity of Wegener's autoantigen (p29) with proteinase 3 and myeloblastin [letter] [PDF]
Blood, 1990 Gupta Sk +3 more
+5 more sources
Chemical Profiling, In Silico and In Vitro Studies to Identify Potential CDK2 and mTOR Inhibitor From Selaginella inaequalifolia (Hook. & Grev.) Spring Ethanolic Extracts. [PDF]
Chem BiodiversABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Antonysamy JMA +4 more
europepmc +2 more sources
Effect of food intake on 92 biomarkers for cardiovascular disease. [PDF]
PLoS ONE, 2017 OBJECTIVE:The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease (CVD). METHODS:Twenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated.
Magnus Dencker +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Sjögren’s Syndrome (SS) is an autoimmune exocrinopathy characterized by the progressive damage of salivary and lacrimal glands associated with lymphocytic infiltration.
Laís Garreto +14 more
doaj +1 more source
Non‐invasive diagnosis of early cutaneous squamous cell carcinoma
Experimental Dermatology, Volume 32, Issue 11, Page 1946-1959, November 2023., 2023 Abstract Early cutaneous squamous cell carcinoma (cSCC) can be challenging to diagnose using clinical criteria as it could present similar to actinic keratosis (AK) or Bowen's disease (BD), precursors of cSCC. Currently, histopathological assessment of an invasive biopsy is the gold standard for diagnosis.
Ali Azimi +3 more
wiley +1 more source