Results 151 to 160 of about 396,076 (261)

Mincle-dependent Th17 adjuvanticity requires TNFR1 signaling in myeloid cells. [PDF]

Front Immunol
Blamberg R, Haberkamp C, Pedersen GK, Rosenkrands I, Schleicher U, Schraml BU, Yamasaki S, Lang R.   +7 more
europepmc   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen. [PDF]

Cell Rep
McCourt B, Lemr K, Chakrabarti S, Woidke E, Ramaiah S, Singh V, Sangwan N, Brown JM, Cominelli F, Rodriguez-Palacios A, Burberry A.   +10 more
europepmc   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart. [PDF]

Immunity
Downey J, Oliveira-Coelho A, Kiss MG, Laghlali G, Leunig A, Radkevich E, Halasz L, Umali M, da Silva JF, Eller ML, Gianeselli M, Żak MM, Randolph HE, Caumartin G, Poller WC, Janssen H, Koekkoek LL, Abdul-Ghafar J, Huynh P, D'Souza D, Roudko V, Nauta S, Munitz J, Li X, Rathner T, Chen Z, Phan A, Glick A, Cialowicz K, Chen Z, Kim-Schulze S, Yoon S, Nahrendorf M, Sahoo S, Merad M, García-Sastre A, McAlpine CS, Strijkers GJ, Simon V, Brody R, Mehandru S, Fayad ZA, Kleinstiver BP, Zangi L, van Leent MMT, Schotsaert M, Swirski FK.   +46 more
europepmc   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas. [PDF]

J Exp Med
Zheng Y, Jean Pierre M, Ansaldo E, Dobson HE, Kamenyeva O, Onyishi CU, Douglas S, Febres Aldana C, Engin Zerk P, Sereti I, Betancourt JJ, Nielsen K, McCaffery E, Dang EV.   +13 more
europepmc   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Old Blood, Young Bones: Identification of Middle-Aged Myeloid Cells That Limit Cortical Bone Loss. [PDF]

J Cell Mol Med
Koroth J, Karkache IY, Vu EK, Manser JC, Shimak MJ, Mansky KC, Bradley EW.   +6 more
europepmc   +1 more source