Results 121 to 130 of about 126,969 (246)

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Analysis of single nuclear chromatin accessibility reveals unique myeloid populations in human pancreatic ductal adenocarcinoma

Clinical and Translational Medicine
Background A better understanding of the pancreatic ductal adenocarcinoma (PDAC) immune microenvironment is critical to developing new treatments and improving outcomes.
Hillary G. Pratt, Li Ma, Sebastian A. Dziadowicz, Sascha Ott, Thomas Whalley, Barbara Szomolay, Timothy D. Eubank, Gangqing Hu, Brian A. Boone   +8 more
doaj   +1 more source

Cooperation between cGAS and RIG-I sensing pathways enables improved innate recognition of HIV-1 by myeloid dendritic cells in elite controllers. [PDF]

Front Immunol, 2022
Martin-Gayo E, Gao C, Calvet-Mirabent M, Ouyang Z, Lichterfeld M, Yu XG.   +5 more
europepmc   +1 more source

NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer

Advanced Science, EarlyView.
Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen, Yi‐Fan Zhou, Xuan Qi, Ya‐Xin Zhao, Tong Fu, Xi Jin, Minhong Shen, Yi‐Zhou Jiang, Zhi‐Ming Shao   +8 more
wiley   +1 more source

Unraveling the Effects of a Talimogene Laherparepvec (T-VEC)-Induced Tumor Oncolysate on Myeloid Dendritic Cells. [PDF]

Front Immunol, 2021
Tijtgat J, De Munck J, Dufait I, Schwarze JK, Van Riet I, Franceschini L, Breckpot K, Aerts JL, Neyns B, Tuyaerts S.   +9 more
europepmc   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

Frontiers in Immunology
ObjectivesDespite their efficacy, some immunotherapies have been shown to induce immune-related adverse events, including the potentially life-threatening cytokine release syndrome (CRS), calling for reliable and translational preclinical models to ...
Gaëlle H. Martin, Alexis Gonon, Perrine Martin-Jeantet, Florence Renart-Depontieu, Zuzana Biesova, Anokhi Cifuentes, Arnab Mukherjee, Thomas Thisted, Astrid Doerner, Dean O. Campbell, Ludovic Bourré, Edward H. van der Horst, Amélie Rezza, Kader Thiam   +13 more
doaj   +1 more source

Myeloid Dendritic Cells Are Major Producers of IFN-β in Dermatomyositis and May Contribute to Hydroxychloroquine Refractoriness. [PDF]

J Invest Dermatol, 2021
Chen KL, Patel J, Zeidi M, Wysocka M, Bashir MM, Patel B, Maddukuri S, White B, Werth VP.   +8 more
europepmc   +1 more source

RIPK3 Orchestrates Scar‐Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis

Advanced Science, EarlyView.
Beyond signaling cell death, RIPK3 emerges as a critical metabolic regulator in pulmonary fibrosis. This research reveals that RIPK3 promotes PI3K‐AKT signaling in scar‐associated macrophages to fuel polyamine synthesis, independent of its kinase activity.
Tao Yang, Xiao Li, Shuyue Lei, Qingqing Li, Yi Zhang, Zhizhen Hui, Jinjin Ren, Xuelian Yang, Xiaoqian Yang, Chunlan Feng, Yousheng Xu, Dongxin Zhao, Wei Tang   +12 more
wiley   +1 more source

Oncolytic Herpes Simplex Virus Type 1 Induces Immunogenic Cell Death Resulting in Maturation of BDCA-1⁺ Myeloid Dendritic Cells. [PDF]

Int J Mol Sci, 2022
Kalus P, De Munck J, Vanbellingen S, Carreer L, Laeremans T, Broos K, Dufait I, Schwarze JK, Van Riet I, Neyns B, Breckpot K, Aerts JL.   +11 more
europepmc   +1 more source