Results 131 to 140 of about 4,660,604 (252)

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

Unraveling the Effects of a Talimogene Laherparepvec (T-VEC)-Induced Tumor Oncolysate on Myeloid Dendritic Cells. [PDF]

Front Immunol, 2021
Tijtgat J, De Munck J, Dufait I, Schwarze JK, Van Riet I, Franceschini L, Breckpot K, Aerts JL, Neyns B, Tuyaerts S.   +9 more
europepmc   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Analysis of single nuclear chromatin accessibility reveals unique myeloid populations in human pancreatic ductal adenocarcinoma

Clinical and Translational Medicine
Background A better understanding of the pancreatic ductal adenocarcinoma (PDAC) immune microenvironment is critical to developing new treatments and improving outcomes.
Hillary G. Pratt, Li Ma, Sebastian A. Dziadowicz, Sascha Ott, Thomas Whalley, Barbara Szomolay, Timothy D. Eubank, Gangqing Hu, Brian A. Boone   +8 more
doaj   +1 more source

Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

Frontiers in Immunology
ObjectivesDespite their efficacy, some immunotherapies have been shown to induce immune-related adverse events, including the potentially life-threatening cytokine release syndrome (CRS), calling for reliable and translational preclinical models to ...
Gaëlle H. Martin, Alexis Gonon, Perrine Martin-Jeantet, Florence Renart-Depontieu, Zuzana Biesova, Anokhi Cifuentes, Arnab Mukherjee, Thomas Thisted, Astrid Doerner, Dean O. Campbell, Ludovic Bourré, Edward H. van der Horst, Amélie Rezza, Kader Thiam   +13 more
doaj   +1 more source

Oncolytic Herpes Simplex Virus Type 1 Induces Immunogenic Cell Death Resulting in Maturation of BDCA-1⁺ Myeloid Dendritic Cells. [PDF]

Int J Mol Sci, 2022
Kalus P, De Munck J, Vanbellingen S, Carreer L, Laeremans T, Broos K, Dufait I, Schwarze JK, Van Riet I, Neyns B, Breckpot K, Aerts JL.   +11 more
europepmc   +1 more source

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Immunological mechanisms controlling chronic inflammatory diseases

, 2009
Autoimmune diseases (AID) are chronic inflammatory diseases (CID) mediated by self-reactive T and B cells and are generally the results of the breakdown of T cell tolerance to self-antigen and failure of peripheral regulatory mechanisms. In this thesis I
Cexus, Olivier
core   +1 more source

HMGB1 Activates Myeloid Dendritic Cells by Up-Regulating mTOR Pathway in Systemic Lupus Erythematosus. [PDF]

Front Med (Lausanne), 2021
Song X, Zhang H, Zhao Y, Lin Y, Tang Q, Zhou X, Zhong X.   +6 more
europepmc   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source