Results 161 to 170 of about 4,990,718 (300)

Analysis of single nuclear chromatin accessibility reveals unique myeloid populations in human pancreatic ductal adenocarcinoma

Clinical and Translational Medicine
Background A better understanding of the pancreatic ductal adenocarcinoma (PDAC) immune microenvironment is critical to developing new treatments and improving outcomes.
Hillary G. Pratt, Li Ma, Sebastian A. Dziadowicz, Sascha Ott, Thomas Whalley, Barbara Szomolay, Timothy D. Eubank, Gangqing Hu, Brian A. Boone   +8 more
doaj   +1 more source

HMGB1 Activates Myeloid Dendritic Cells by Up-Regulating mTOR Pathway in Systemic Lupus Erythematosus. [PDF]

Front Med (Lausanne), 2021
Song X, Zhang H, Zhao Y, Lin Y, Tang Q, Zhou X, Zhong X.   +6 more
europepmc   +1 more source

Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes

Advanced Science, EarlyView.
The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu, Zhiyue Fan, Lin Lv, Wei Lu, Zhenfan Wen, Wukun Liu   +5 more
wiley   +1 more source

Oncolytic Herpes Simplex Virus Type 1 Induces Immunogenic Cell Death Resulting in Maturation of BDCA-1⁺ Myeloid Dendritic Cells. [PDF]

Int J Mol Sci, 2022
Kalus P, De Munck J, Vanbellingen S, Carreer L, Laeremans T, Broos K, Dufait I, Schwarze JK, Van Riet I, Neyns B, Breckpot K, Aerts JL.   +11 more
europepmc   +1 more source

Dendritic Cells as a Therapeutic Strategy in Acute Myeloid Leukemia: Vaccines

Vaccines
Dendritic cells (DCs) serve as professional antigen-presenting cells (APC) bridging innate and adaptive immunity, playing an essential role in triggering specific cellular and humoral responses against tumor and infectious antigens. Consequently, various DC-based antitumor therapeutic strategies have been developed, particularly vaccines, and have been
Francisca Palomares, Alejandra Pina, Hala Dakhaoui, Camila Leiva-Castro, Ana M. Munera-Rodriguez, Marta Cejudo-Guillen, Beatriz Granados, Gonzalo Alba, Consuelo Santa-Maria, Francisco Sobrino, Soledad Lopez-Enriquez   +10 more
openaire   +7 more sources

Phenotypic characterization of lymphoid and myeloid subsets.

, 2012
Representative polychromatic flow cytometric analysis of lymphoid (A) and myeloid (B) subsets from PBMCs. Mem B (Memory B-cells), CM (Central memory), EM (Effector memory), NK (Natural killer), mDCs (Myeloid Dendritic cells), pDCs (Plasmacytoid dendritic
Timothy Weeden (156069), Sambasiva P. Rao (156059), Johanne M. Kaplan (156074), Srinivas Shankara (156070), Jose Sancho (156061), Bruce L. Roberts (156072), Juanita Campos-Rivera (156064), Peter B. Severy (156067), Paula M. Boutin (156066)   +8 more
core   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Intravenous immunoglobulin induces IgG internalization by tolerogenic myeloid dendritic cells that secrete IL-10 and expand Fc-specific regulatory T cells. [PDF]

Clin Exp Immunol, 2022
Hsieh LE, Song J, Tremoulet AH, Burns JC, Franco A.   +4 more
europepmc   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

Percentage of Myeloid Dendritic Cells in Peripheral Venous Blood Is Negatively Related to Incidence of Graves' Orbitopathy. [PDF]

Mediators Inflamm, 2021
Wojciechowska-Durczynska K, Wieczorek-Szukala K, Stefanski B, Zygmunt A, Stepniak J, Karbownik-Lewinska M, Lewinski A.   +6 more
europepmc   +1 more source