Results 231 to 240 of about 132,354 (264)

Dendritic cell vaccination in acute myeloid leukemia

Cytotherapy, 2012
The prognosis of patients with acute myeloid leukemia (AML) remains dismal, with a 5-year overall survival rate of only 5.2% for the continuously growing subgroup of AML patients older than 65 years. These patients are generally not considered eligible for intensive chemotherapy and/or allogeneic hematopoietic stem cell transplantation because of high ...
Anguille, Sébastien, Willemen, Yannick, Lion, Eva, Smits, Evelien L., Berneman, Zwi N.   +4 more
openaire   +3 more sources

Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells

Blood, 2008
Abstract The migratory properties of dendritic cells (DCs) are important for their functions. Although several chemokines and their receptors have been implicated in DC migration, the downstream signaling molecules are largely unknown.
Kazuhito, Gotoh, Yoshihiko, Tanaka, Akihiko, Nishikimi, Ayumi, Inayoshi, Munechika, Enjoji, Ryoichi, Takayanagi, Takehiko, Sasazuki, Yoshinori, Fukui   +7 more
openaire   +2 more sources

Stimulatory and Inhibitory Differentiation of Human Myeloid Dendritic Cells

Clinical Immunology, 2000
Dendritic cells (DCs) play a critical obligate role in presenting antigens to T cells for activation. In the process, upon antigen capture, DCs undergo maturation and become more stimulatory. Human myeloid DCs can be generated from various sources, including blood, bone marrow, and CD34(+) stem cells.
A, Chakraborty, L, Li, N G, Chakraborty, B, Mukherji   +3 more
openaire   +2 more sources

Dendritic cell potentials of early lymphoid and myeloid progenitors

Blood, 2001
It has been proposed that there are at least 2 classes of dendritic cells (DCs), CD8α+ DCs derived from the lymphoid lineage and CD8α− DCs derived from the myeloid lineage. Here, the abilities of lymphoid- and myeloid-restricted progenitors to generate DCs are compared, and their overall contributions to the DC compartment are evaluated.
M G, Manz, D, Traver, T, Miyamoto, I L, Weissman, K, Akashi   +4 more
openaire   +2 more sources

Myeloid dendritic cells type 2 in allergic asthma

Allergy: European Journal of Allergy and Clinical Immunology, 2013
AbstractBackgroundMyeloid dendritic cells type 2 (mDC2s) are a new subtype of DCs identified in both the circulation and the lung and suggested to have a role in allergic asthma.MethodsCirculating mDC2s were enumerated in 19 healthy, 18 atopic nonasthmatic, 18 mild atopic asthmatic, and 16 moderate/severe atopic asthmatic subjects using flow cytometry ...
Paul O'Byrne
exaly   +3 more sources

IFN regulation and functions in myeloid dendritic cells

Cytokine & Growth Factor Reviews, 2008
A central issue in dendritic cells (DC) biology is to understand how type I IFNs modulate the immuno-regulatory properties of DC. In this review I will address this issue in light of the recent experimental evidence on the expression and function of these cytokines in myeloid DC.
openaire   +2 more sources

Human myeloid dendritic cells are refractory to tryptophan metabolites

Human Immunology, 2011
The enzyme indoleamine 2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan and is expressed, among other cell types, in immune cells such as dendritic cells (DCs), monocytes, and macrophages. It has been shown that the activity of IDO has a broad regulatory function in the immune system by inhibiting effector T-cell responses, inducing ...
Dagmar, von Bubnoff, Helene, Wilms, Marina, Scheler, Manuela, Brenk, Susanne, Koch, Thomas, Bieber   +5 more
openaire   +2 more sources

Dendritic Cell Development from Common Myeloid Progenitors

Annals of the New York Academy of Sciences, 2001
Abstract: Dendritic cells (DCs) are professional antigen‐presenting cells which both initiate adaptive immune responses and control tolerance to self‐antigens. It has been suggested that these different effects on responder cells depend on subsets of DCs arising from either myeloid or lymphoid hematopoietic origins. In this model, CD8α+ Mac‐1− DCs are
M G, Manz, D, Traver, K, Akashi, M, Merad, T, Miyamoto, E G, Engleman, I L, Weissman   +6 more
openaire   +2 more sources

Dendritic cells of myeloid lineage

Current Opinion in Organ Transplantation, 2014
Advances in surgery, patient management, and pharmacologic immunosuppression have reduced the incidence of acute allograft rejection. However, generation of therapies to promote donor-specific immunosuppression with minimal side-effects has proved to be a difficult task.
openaire   +2 more sources

FUNCTION OF MYELOID DENDRITIC CELLS

2012
Approximately 70% of patients infected with hepatitis C virus (HCV) develop chronic infection, which has been reported to be due to impaired specific T cell responses. Myeloid dendritic cells (mDCs) are potent antigen-presenting cells that regulate T cell responses, however their role during chronic hepatitis C (CHC) is not fully understood.
openaire   +1 more source