Results 51 to 60 of about 6,004,355 (246)

Salvianolic Acids Alleviate Chronic Mild Stress-Induced Depressive-Like Behaviors in Rats

Journal of Integrative Neuroscience, 2023
Background: Salvianolic acids possess anti-inflammatory properties. This study investigated the therapeutic effect of salvianolic acids on chronic mild stress (CMS)-induced depressive-like behaviors in rats and the involvement of toll-like receptor 4 ...
Fengya Zhen, Lulu Yu, Lan Wang, Shuo Wang, Wenting Lu, Xueyi Wang, Cuixia An   +6 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Effect of Moxibustion Stimulation of“Feishu”(BL 13)and“Xinshu”(BL 15)on Expression of Myocardial MyD 88 Protein and Caspase 3mRNA in Chronic Heart Failure Rats

针刺研究, 2016
Objective To observe the effect of moxibustion stimulation of"Feishu"(BL 13)and"Xinshu"(BL 15)on pathological changes of myocardium and the expression of myocardial myeloid differentiation factor 88(MyD 88)protein and Caspase 3mRNA in chronic heart ...
WANG Jing, ZENG Yong-lei, WU Feng-qin, SUN Rui-rui, CHEN Jing, JIA Xue-zhao, XI Yu-hong   +6 more
doaj   +2 more sources

Polyphenon E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Note: In this manuscript as well as in the original published version of this article the word "Polyphenon" was incorrectly spelled in the title as ...
Chayka, O, Sala, A, Piotrowska, I, Himoudi, N, D'Alicarnasso, M, Cantilena, S, Santilli, G, Morgenstern, DA, Thrasher, AJ, Pearson, K, Anderson, J   +10 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

MyD88 signaling pathways: role in breast cancer

Frontiers in Oncology
MyD88 plays a central role in breast cancer, exerting a multitude of effects that carry substantial implications. Elevated MyD88 expression is closely associated with aggressive tumor characteristics, suggesting its potential as a valuable prognostic ...
Hongmei Zheng, Xinhong Wu, Liantao Guo, Jianhua Liu   +3 more
doaj   +1 more source

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment [PDF]

, 2009
Background: t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome – Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid ...
Xiaomin Zheng, Malcolm A S Moore, Martin Ruthardt, Ruthardt, Martin, Oancea, Claudia, Claudia Oancea, Malcolm A. S. Moore, Reinhard Henschler, Henschler, Reinhard, Moore, Malcolm A. S., Zheng, Xiaomin   +10 more
core   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The immunostimulatory effect of indole-6-carboxaldehyde isolated from Sargassum thunbergii (Mertens) Kuntze in RAW 264.7 macrophages

Animal Cells and Systems, 2020
Indole-6-carboxaldehyde (I6CA), an indole derivative isolated from the marine brown algae Sargassum thunbergii, is known to have several beneficial effects, but no studies on immune regulation have been conducted.
Cheol Park, Hyun HwangBo, Hyesook Lee, Gi-Young Kim, Hee-Jae Cha, Sung Hyun Choi, Suhkmann Kim, Heui-Soo Kim, Seok Joong Yun, Wun-Jae Kim, You-Jin Jeon, Yung Hyun Choi   +11 more
doaj   +1 more source

Astragaloside IV Improves High-Fat Diet–Induced Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Rats by Regulating Inflammatory Factors Level via TLR4/NF-κB Signaling Pathway

Frontiers in Pharmacology, 2021
Objective: Astragaloside IV (AS-IV) is the primary bioactive component purified from Astragalus membranaceus which is one of the traditional Chinese medicines.
Ying-Li Liu, Ying-Li Liu, Qiu-Zan Zhang, Qiu-Zan Zhang, Yan-Rong Wang, Yan-Rong Wang, Li-Na Fu, Li-Na Fu, Jing-Shu Han, Jing-Shu Han, Jing Zhang, Jing Zhang, Bang-Mao Wang   +12 more
doaj   +1 more source