Results 51 to 60 of about 160,066 (290)

Effect of Pricking-bloodletting Therapy Combined with Zhuang-medicine-thread Moxibustion on TLRs/MyD88 Signal Pathway in a Rat Model of Acute Gouty Arthritis [PDF]

Zhongguo quanke yixue, 2023
Background With the change of people's environment and diet structure, acute gouty arthritis (AGA) has become a common clinical disease, which is prone to recurrence, causing harm to patients' health. Pricking-bloodletting therapy combined with
ZHU Danmeng, HUANG Yuying, LUO Tong'an, HE Changyuan, CHEN Rilan
doaj   +1 more source

Ramulus Cinnamomi extract attenuates neuroinflammatory responses via downregulating TLR4/MyD88 signaling pathway in BV2 cells

Neural Regeneration Research, 2017
Ramulus Cinnamomi (RC), a traditional Chinese herb, has been used to attenuate inflammatory responses. The purpose of this study was to investigate the effect of RC extract on lipopolysaccharide (LPS)-induced neuroinflammation in BV2 microglial cells and
Huan Yang, Xiao Cheng, Ying-lin Yang, Yue-hua Wang, Guan-hua Du   +4 more
doaj   +1 more source

Regulation of human formyl peptide receptor 1 synthesis: role of single nucleotide polymorphisms, transcription factors, and inflammatory mediators. [PDF]

PLoS ONE, 2011
The gene encoding the human formyl peptide receptor 1 (FPR1) is heterogeneous, containing numerous single nucleotide polymorphisms (SNPs). Here, we examine the effect of these SNPs on gene transcription and protein translation.
Heini M Miettinen
doaj   +1 more source

Targeting the Spleen as an Alternative Site for Hematopoiesis [PDF]

, 2019
Bone marrow is the main site for hematopoiesis in adults. It acts as a niche for hematopoietic stem cells (HSC) and contains non-hematopoietic cells that contribute to stem cell dormancy, quiescence, self-renewal and differentiation.
Lim, Hong, O'Neill, Helen C, Short, Christie, Tan, Jonathan Kah Huat   +3 more
core   +1 more source

Epithelial Myeloid-Differentiation Factor 88 Is Dispensable during Klebsiella Pneumonia

American Journal of Respiratory Cell and Molecular Biology, 2017
Abstract Klebsiella pneumoniae is a common cause of pneumonia. Previous studies have documented an important role for Toll-like receptors (TLRs) expressed by myeloid cells in the recognition of K. pneumoniae and the initiation of a protective immune response. Lung epithelial cells also express TLRs and can participate in innate immune
Anas, Adam A., Claushuis, Theodora A. M., Mohan, Rajiv A., Christoffels, Vincent M., Aidinis, Vassilis, Florquin, Sandrine, van't Veer, Cornelis, Hou, Baidong, de Vos, Alex F., van der Poll, Tom   +9 more
openaire   +3 more sources

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. [PDF]

, 2014
Low-grade systemic inflammation is often associated with metabolic syndrome, which plays a critical role in the development of the obesity-associated inflammatory diseases, including insulin resistance and atherosclerosis.
DeFranco, Anthony L, Dicorleto, Paul E, Febbraio, Maria, Fox, Paul L, Harding, Clifford V, Hazen, Stanley L, Hise, Amy G, Hu, Bingqing, Li, Xiaoxia, Morton, Richard E, Nagy, Laura E, Ransohoff, Richard M, Roychowdhury, Sanjoy, Schmitt, David, Smith, Jonathan D, Wang, Jian-an, Xiao, Nengming, Yu, Minjia, Zhao, Junjie, Zhou, Hao   +19 more
core   +2 more sources

Prognostic significance of MyD88 expression by human epithelial ovarian carcinoma cells

Journal of Translational Medicine, 2012
Background MyD88 is an adaptor protein for TLR-4 signaling known to mediate paclitaxel resistance in epithelial ovarian carcinoma (EOC). This study examined the clinical significance of MyD88 expression in EOC.
Zhu Yi, Huang Jian-Ming, Zhang Guo-Nan, Zha Xiao, Deng Bi-Fang   +4 more
doaj   +1 more source

LXR agonist inhibits inflammation through regulating MyD88 mRNA alternative splicing

Frontiers in Pharmacology, 2022
Liver X receptors (LXRs) are important regulators of cholesterol metabolism and inflammatory responses. LXR agonists exhibit potently anti-inflammatory effects in macrophages, which make them beneficial to anti-atherogenic therapy.
Ni Li, Ni Li, Yan Li, Xiaowan Han, Jing Zhang, Jiangxue Han, Xinhai Jiang, Weizhi Wang, Yang Xu, Yanni Xu, Yu Fu, Shuyi Si   +11 more
doaj   +1 more source

Cytokines of Birds: Conserved Functions [PDF]

, 2001
Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight
Göbel, Thomas W. F., Kaspers, Bernd, Puehler, Florian, Schneider, Kirsten, Staeheli, Peter   +4 more
core   +1 more source

ST2825, independent of MyD88, induces reactive oxygen species-dependent apoptosis in multiple myeloma cells

Biochemistry and Biophysics Reports
Myeloid differentiation factor 88 (MyD88), which is a key regulator of nuclear factor kappa B (NF-κB), plays an important role in tumorigenesis in lymphoid malignancies such as Waldenstrom's macroglobulinemia (WM).
Hajime Nakamura, Yohei Arihara, Makoto Usami, Kohichi Takada   +3 more
doaj   +1 more source