Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]
, 2017 Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo +23 more
core +4 more sources
Role of mTOR signaling in tumor microenvironment. An overview [PDF]
, 2018 The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara +8 more
core +2 more sources
From phagocytosis to metaforosis: calcineurin's deadly role in innate processing of fungi [PDF]
, 2018 African trypanosomiasis is a chronic debilitating disease affecting the health and economic well-being of many people in developing countries. The pathogenicity associated with this disease involves a persistent inflammatory response, whereby M1-type ...
Armstrong-James, D +3 more
core +8 more sources
Protective effect of leaf essential oil from Cinnamomum osmophloeum Kanehira on endotoxin-induced intestinal injury in mice associated with suppressed local expression of molecules in the signaling pathways of TLR4 and NLRP3. [PDF]
PLoS ONE, 2015 Endotoxin is a potent microbial mediator implicated in sepsis. We investigated the anti-inflammatory effect of leaf essential oil from Cinnamomum osmophloeum Kanehira (CO) of the linalool chemotype on endotoxin-injected mice. Mice were administered CO or
Shih-Chieh Lee +4 more
doaj +1 more source
Heliyon, 2023 Long-term consumption of Arctium lappa L. roots can lead to weight loss. To explore the relationship between anti-obesity and anti-inflammation, the effects and mechanism of A. lappa L.
Feng Zeng +6 more
doaj +1 more source
Targeting self-renewal pathways in myeloid malignancies [PDF]
, 2013 A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core +2 more sources
Tumor Biology, 2017 High mobility group box 1 and toll-like receptor 4/myeloid differentiation factor 88 signaling pathway have been indicated to have oncogenic effects in many cancers.
Yanqiu Yue +8 more
doaj +1 more source
Radiation-induced myeloid leukemia in murine models. [PDF]
, 2014 The use of radiation therapy is a cornerstone of modern cancer treatment. The number of patients that undergo radiation as a part of their therapy regimen is only increasing every year, but this does not come without cost.
Davoren, Michael +2 more
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Aberrant Inflammatory Response to Streptococcus pyogenes in Mice Lacking Myeloid Differentiation Factor 88 [PDF]
The American Journal of Pathology, 2010 Several in vitro studies have emphasized the importance of toll-like receptor/myeloid differentiation factor 88 (MyD88) signaling in the inflammatory response to Streptococcus pyogenes. Since the extent of inflammation has been implicated in the severity of streptococcal diseases, we have examined here the role of toll-like receptor/MyD88 signaling in ...
Torsten G, Loof +4 more
openaire +2 more sources
Similar structures but different roles - An updated perspective on TLR structures
Frontiers in Physiology, 2011 Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) that recognize conserved structures in pathogens, trigger innate immune responses and prime antigen-specific adaptive immunity. Elucidation of crystal structures of TLRs interacting with
Balachandran eManavalan +2 more
doaj +1 more source