Results 31 to 40 of about 6,004,355 (246)

ST2825, independent of MyD88, induces reactive oxygen species-dependent apoptosis in multiple myeloma cells

Biochemistry and Biophysics Reports
Myeloid differentiation factor 88 (MyD88), which is a key regulator of nuclear factor kappa B (NF-κB), plays an important role in tumorigenesis in lymphoid malignancies such as Waldenstrom's macroglobulinemia (WM).
Hajime Nakamura, Yohei Arihara, Makoto Usami, Kohichi Takada   +3 more
doaj   +1 more source

Ramulus Cinnamomi extract attenuates neuroinflammatory responses via downregulating TLR4/MyD88 signaling pathway in BV2 cells

Neural Regeneration Research, 2017
Ramulus Cinnamomi (RC), a traditional Chinese herb, has been used to attenuate inflammatory responses. The purpose of this study was to investigate the effect of RC extract on lipopolysaccharide (LPS)-induced neuroinflammation in BV2 microglial cells and
Huan Yang, Xiao Cheng, Ying-lin Yang, Yue-hua Wang, Guan-hua Du   +4 more
doaj   +1 more source

Forsythiasides: A review of the pharmacological effects

Frontiers in Cardiovascular Medicine, 2022
Forsythiasides are a kind of phenylethanol glycosides existing in Forsythia suspensa (Thunb.) Vahl, which possesses extensive pharmacological activities.
Hong-Xuan Yang, Qiu-Ping Liu, Yan-Xi Zhou, Yan-Xi Zhou, Yu-Ying Chen, Pei An, Yi-Zhuo Xing, Lei Zhang, Min Jia, Hong Zhang   +9 more
doaj   +1 more source

Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts

BMC Complementary Medicine and Therapies, 2020
Background Previous studies indicate that soyasaponins may reduce inflammation via modulating toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling. However, its underlying mechanisms are still not fully understood.
Junbin Chen, Hidayat Ullah, Zhongdaixi Zheng, Xiangfu Gu, Chuhong Su, Lingyu Xiao, Xinglong Wu, Fei Xiong, Qing Li, Longying Zha   +9 more
doaj   +1 more source

Regulation of human formyl peptide receptor 1 synthesis: role of single nucleotide polymorphisms, transcription factors, and inflammatory mediators. [PDF]

PLoS ONE, 2011
The gene encoding the human formyl peptide receptor 1 (FPR1) is heterogeneous, containing numerous single nucleotide polymorphisms (SNPs). Here, we examine the effect of these SNPs on gene transcription and protein translation.
Heini M Miettinen
doaj   +1 more source

Proteomics of Acute Myeloid Leukemia [PDF]

, 2007
Acute Myeloid Leukemia (AML) is characterized by specific cytogenetic aberrations that are strong determinants of prognostic outcome and therapeutic response.
Yaseen, Mumtaz
core   +1 more source

The granulocytic inducer C/EBPalpha inactivates the myeloid master regulator PU.1 [PDF]

, 2003
Verschiedene Transkriptionsfaktoren spielen eine Rolle in der Entwicklung myeloischer Zellen. PU.1, ein Transkriptionsfaktor aus der ETS-Familie, ist sowohl für die Entwicklung lymphatischer als auch für die Entwicklung myeloischer Zellen von Bedeutung ...
Reddy, Venkateshwar
core   +1 more source

Prognostic significance of MyD88 expression by human epithelial ovarian carcinoma cells

Journal of Translational Medicine, 2012
Background MyD88 is an adaptor protein for TLR-4 signaling known to mediate paclitaxel resistance in epithelial ovarian carcinoma (EOC). This study examined the clinical significance of MyD88 expression in EOC.
Zhu Yi, Huang Jian-Ming, Zhang Guo-Nan, Zha Xiao, Deng Bi-Fang   +4 more
doaj   +1 more source

Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia [PDF]

, 2009
<b>Background</b>: The majority of acute myeloid leukaemia (AML) patients are over sixty years of age. With current treatment regimens, survival rates amongst these, and also those younger patients who relapse, remain dismal and novel ...
Gunther Ulrich L., Gunther, U., Khanim, F.L., Alessia Lodi, Jim A Murray, Birtwistle Jane, Lodi, A, Chris, M., Gunther, Ulrich L., Khanim, Farhat L., Drayson, Mark T., Khanim Farhat L., Murray, James, Mountford, Joanne C., Murray, J.A., Ulrich L Gunther, Drayson, M., Tiziani, S, Gunther, U.L., Jane Birtwistle, Green Richard M., Farhat L Khanim, Bunce, Christopher, Hayden, R.E., Ride, Jon P., Murray, J., Mountford, J.C., Mark T Drayson, Davies, N., Schrewe, H., Stefano Tiziani, Drayson Mark T., Hayden, Rachel, Viant Mark R., Khanim, Farhat, Murray, Jim A., Davies, Nicholas, Lodi, A., Ride, Jonathan, Chris M Bunce, Gunther, Ulrich, Lodi, Alessia, Viant, Mark R., Tiziani, Stefano, Richard M Green, Viant, Mark; id_orcid, Mountford, JC, Ride, J.P., Joanne C Mountford, Green, Richard, Bunce Chris M., Heinrich Schrewe, Murray Jim A., Davies, Nicholas J., Drayson, Mark, Green, R., Schrewe, Heinrich, Mark R Viant, Davies Nicholas J., Jon P Ride, Mountford, J., Ride, J., Viant, M., Lodi Alessia, Drayson, M.T., Birtwistle, J., Hayden, Rachel E., Hayden Rachel E., Tiziani Stefano, Nicholas J Davies, Bunce, C.M., Ride Jon P., Hayden, R., Davies, N.J., Viant, M.R., Mountford Joanne C., Tiziani, S., Khanim, F., Birtwistle, Jane, Chris, M. Bunce, Schrewe Heinrich, Green, Richard M., Rachel E Hayden   +82 more
core   +1 more source

The T-cell oncogene Tal2 is a Target of PU.1 and upregulated during osteoclastogenesis [PDF]

, 2013
Transcription factors play a crucial role in regulating differentiation processes during human life and are important in disease. The basic helix-loop-helix transcription factors Tal1 and Lyl1 play a major role in the regulation of gene expression in the
Stefanie Herkt, Hussong, Helge, Helge Hussong, Christian Mücke, Jörn Lausen, Herkt, Stefanie, Nadine Courtial, Courtial, Nadine, Stephan Kolodziej, Kolodziej, Stephan, Lausen, Jörn, Mücke, Christian   +11 more
core   +1 more source