Results 11 to 20 of about 6,004,355 (246)

High mobility group box 1/toll-like receptor 4/myeloid differentiation factor 88 signaling promotes progression of gastric cancer

Tumor Biology, 2017
High mobility group box 1 and toll-like receptor 4/myeloid differentiation factor 88 signaling pathway have been indicated to have oncogenic effects in many cancers.
Yanqiu Yue, Tao Zhou, Yanjing Gao, Zongli Zhang, Li Li, Lin Liu, Wenna Shi, Lihui Su, Baoquan Cheng   +8 more
doaj   +2 more sources

Inhibition of myeloid differentiation factor 88 signaling mediated by histidine-grafted poly(β-amino ester) ester nanovector induces donor-specific liver allograft tolerance

International Journal of Nanomedicine, 2015
Fanguo Hu,1,* Hanjie Wang,2,* Shuangnan Zhang,2 Yao Peng,2 Lin Su,2 Jin Chang,2 Gang Liu11Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 2School of Life Sciences, Tianjin University,
Hu F, Wang H, Zhang S, Peng Y, Su L, Chang J, Liu G   +6 more
doaj   +1 more source

Inhibition of Mogroside IIIE on isoproterenol-induced myocardial fibrosis through the TLR4/MyD88/NF-κB signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): To investigate the effect of mogroside IIIE (MGIIIE) on isoproterenol (ISO)-induced myocardial fibrosis and explore its possible mechanisms.Materials and Methods: Forty C57BL/6 male mice (6-8 weeks) were randomly divided into a control ...
Yanan Shi, Bohan Li, Shuaifeng Sun, Tian Wendan, Zizhe Ma, Wei Liu   +5 more
doaj   +1 more source

Dihydroartemisinin reduces lung injury in rats with hemorrhagic shock [PDF]

Jichu yixue yu linchuang, 2021
Objective To study the protective effect of dihydroartemisinin (DHA) on lung injury in rats with hemorrhagic shock (HS). Methods The rats were divided into sham operation group, model group (the left common carotid artery was treated by blood ...
YANG Ning, WANG Da-wei, ZHAO Ya-bin, CHANG Dong-ge, HE Ying-ying
doaj  

Effect of human follicle-stimulating hormone on immunomodulatory function of decidual mesenchymal stem cells by reducing interleukin-6 levels

Journal of Ovarian Research, 2022
Objective Women with an elevated basal FSH indicate diminished ovarian reserve and reduced oocyte and embryo numbers. DMSCs are likely to be involved in immune tolerance of pregnancy maintenance. We investigate the effect of follicle-stimulating hormones
Yi-bo He, Li Zhang, Lin-li Zhou, Yi-min Chen, Jia-hong Lu, Jie Chen, Yong-lin Liu   +6 more
doaj   +1 more source

Possible Involvement of MyD88 in Regulating Stress Response in Mice

Frontiers in Neuroscience, 2021
Myeloid differentiation primary response 88 (MyD88) is an adapter protein of the toll-like receptor (TLR) family that regulates innate immune function. Here, we identified a novel role of MyD88 in regulating stress response.
Toru Hosoi, Yosuke Yamawaki, Yosuke Yamawaki, Hitomi Kimura, Shoko Honda, Koichiro Ozawa   +5 more
doaj   +1 more source

Sulforaphane suppresses lipopolysaccharide‐ and Pam3CysSerLys4‐mediated inflammation in chronic obstructive pulmonary disease via toll‐like receptors

FEBS Open Bio, 2021
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disease of the airway that represents a large global disease burden. Inflammation is a prominent feature of COPD and represents an important target for treatment.
Xiaoli Zeng, Xiaoju Liu, Hairong Bao
doaj   +1 more source

Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells [PDF]

, 2002
Expression of the gene for the macrophage colony stimulating factor receptor (CSF-1R), c-fms, has been viewed as a hallmark of the commitment of multipotent precursor cells to macrophages.
Bonifer, Constanze, Pieter J.M. Leenen, Himes, R, Clarke, D, Himes, Roy, Riggs, A. D., Bonifer, Constanze; id_orcid, Tagoh, H., Tagoh, Hiromi, Hume, David, Himes, R., Tagoh, H, Hume, D., Leenen, PJ, Roy Himes, Clarke, D., Bonifer, C, Leenen, Pieter J M, Constanze Bonifer, David Hume, Riggs, AD, Bonifer, C., Leenen, P. J. M., Arthur D. Riggs, Leenen, Pieter, Clarke, Deborah, Hiromi Tagoh, Deborah Clarke, Riggs, Arthur D, Hume, D   +29 more
core   +1 more source

Similar structures but different roles - An updated perspective on TLR structures

Frontiers in Physiology, 2011
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) that recognize conserved structures in pathogens, trigger innate immune responses and prime antigen-specific adaptive immunity. Elucidation of crystal structures of TLRs interacting with
Balachandran eManavalan, Shaherin eBasith, Sangdun eChoi   +2 more
doaj   +1 more source

Protective effect of leaf essential oil from Cinnamomum osmophloeum Kanehira on endotoxin-induced intestinal injury in mice associated with suppressed local expression of molecules in the signaling pathways of TLR4 and NLRP3. [PDF]

PLoS ONE, 2015
Endotoxin is a potent microbial mediator implicated in sepsis. We investigated the anti-inflammatory effect of leaf essential oil from Cinnamomum osmophloeum Kanehira (CO) of the linalool chemotype on endotoxin-injected mice. Mice were administered CO or
Shih-Chieh Lee, Jie-Sheng Hsu, Chien-Chun Li, Ke-Ming Chen, Cheng-Tzu Liu   +4 more
doaj   +1 more source