Results 41 to 50 of about 160,066 (290)
MyD88 Mediates Colitis- and RANKL-Induced Microfold Cell Differentiation
Veterinary Sciences, 2021 Intestinal microfold (M) cells are critical for sampling antigens in the gut and initiating the intestinal mucosal immune response. In this study, we found that the oral administration of dextran sulfate sodium (DSS) and Salmonella infection induced ...
Yang Li +8 more
doaj +1 more source
Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]
, 2014 Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
core +1 more source
Myeloid Differentiation Factor 88–Dependent and –Independent Pathways in Toll‐Like Receptor Signaling [PDF]
The Journal of Infectious Diseases, 2003 Toll-like receptors (TLRs) play an essential role in the detection of invading pathogens in the body. Individual TLRs recognize distinct components derived from pathogens, which is followed by cytokine production. The TLR family harbors extracellular leucine-rich repeat domains and a cytoplasmic domain that is homologous to that of the interleukin (IL)-
Shizuo, Akira, Katuaki, Hoshino
openaire +2 more sources
Synovial tissue macrophages: friend or foe? [PDF]
, 2017 Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that differentiate locally into proinflammatory macrophages, and these produce ...
Alivernini, Stefano +1 more
core +2 more sources
Flagellin Promotes Myeloid Differentiation Factor 88-Dependent Development of Th2-Type Response [PDF]
The Journal of Immunology, 2004 Abstract Activation of dendritic cells (DC) by microbial products via Toll-like receptors (TLR) is instrumental in the induction of immunity. In particular, TLR signaling plays a major role in the instruction of Th1 responses. The development of Th2 responses has been proposed to be independent of the adapter molecule myeloid ...
Didierlaurent A +9 more
openaire +3 more sources
Antioxidants, 2022 Acute kidney injury (AKI) is described as the abrupt decrease in kidney function always accompanied by inflammation. The roots of Oxybaphus himalaicus Edgew. have long been used in Tibetan folk medicine for the treatment of nephritis.
Honghong Zhan +8 more
doaj +1 more source
BMC Complementary Medicine and Therapies, 2020 Background Previous studies indicate that soyasaponins may reduce inflammation via modulating toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling. However, its underlying mechanisms are still not fully understood.
Junbin Chen +9 more
doaj +1 more source
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy [PDF]
, 2017 Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy.
Mai, Antonello +3 more
core +1 more source
Hexa-acylated LPS-lipid A deploys the appropriate level of fibrin to confer protection through MyD88
International Journal of Infectious Diseases, 2015 Objectives: Fibrin has been demonstrated to function protectively against pathogens in our previous studies, but we observed that a very high level of fibrin played a negative role during infection. We performed this research to address the complication.
Qi Zhao +4 more
doaj +1 more source
Forsythiasides: A review of the pharmacological effects
Frontiers in Cardiovascular Medicine, 2022 Forsythiasides are a kind of phenylethanol glycosides existing in Forsythia suspensa (Thunb.) Vahl, which possesses extensive pharmacological activities.
Hong-Xuan Yang +9 more
doaj +1 more source