Results 61 to 70 of about 160,066 (290)

A hitchhiker's guide to myeloid cell subsets: practical implementation of a novel mononuclear phagocyte classification system [PDF]

, 2015
The classification of mononuclear phagocytes as either dendritic cells or macrophages has been mainly based on morphology, the expression of surface markers, and assumed functional specialization.
Adams, Ajami, Ajami, Bachem, Bachem, Bain, Bain, Balan, Becker, Benson, Bogunovic, Breton, Caton, Caux, Cheong, Chorro, Chou, Cisse, Contreras, Coombes, Crozat, Crozat, Crozat, Desch, Diao, Durand, Edelson, Epelman, Gao, Gatto, Gautier, Geissmann, Geurtsvankessel, Ghosh, Ginhoux, Ginhoux, Ginhoux, Gomez Perdiguero, Grajales-Reyes, Guilliams, Guilliams, Guilliams, Guilliams, Guilliams, Guilliams, Gurka, Hacker, Hashimoto, Helft, Hettinger, Hildner, Hoeffel, Hoeffel, Inaba, Jackson, Jaitin, Jakubzick, Jang, Janssen, Jha, Karsunky, Kashiwada, Kuipers, Lavin, Lee, Lewis, McKenna, Merad, Miller, Molawi, Murray, Naik, Naik, Naik, Ohl, Onai, Onai, Palucka, Persson, Plantinga, Poltorak, Poulin, Pulendran, Randolph, Reynolds, Robbins, Sallusto, Salomon, Satpathy, Saunders, Schiavoni, Schlitzer, Schlitzer, Schraml, Schulz, Scott, Serbina, Shalek, Siddiqui, Sun, Suzuki, Swirski, Tailor, Tamoutounour, Tamoutounour, Tamura, Tussiwand, van Furth, van Furth, Varol, Varol, Varol, Vu Manh, Vu Manh, Vu Manh, Waskow, Wimmers, Wu, Xu, Xue, Yamasaki, Yona, Yona, Zigmond   +123 more
core   +2 more sources

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source

Toll-like Receptor-9 (TLR-9) Signaling Is Crucial for Inducing Protective Immunity following Immunization with Genetically Modified Live Attenuated Leishmania Parasites

Pathogens, 2023
No human vaccine is available for visceral leishmaniasis (VL). Live attenuated centrin gene-deleted L. donovani (LdCen−/−) parasite vaccine has been shown to induce robust innate immunity and provide protection in animal models. Toll-like receptors (TLRs)
Parna Bhattacharya, Sreenivas Gannavaram, Nevien Ismail, Ankit Saxena, Pradeep K. Dagur, Adovi Akue, Mark KuKuruga, Hira L. Nakhasi   +7 more
doaj   +1 more source

Clec9a-mediated ablation of conventional dendritic cells suggests a lymphoid path to generating dendritic cells In Vivo [PDF]

, 2018
Conventional dendritic cells (cDCs) are versatile activators of immune responses that develop as part of the myeloid lineage downstream of hematopoietic stem cells.
Keppler, SJ, Pakalniškytė, D, Papaioannou, NE, Pasztoi, M, Rambichler, S, Reis E Sousa, C, Rogers, NC, Salvermoser, J, Schraml, BU, Straub, T, Van Blijswijk, J   +10 more
core   +1 more source

Salvianolic Acids Alleviate Chronic Mild Stress-Induced Depressive-Like Behaviors in Rats

Journal of Integrative Neuroscience, 2023
Background: Salvianolic acids possess anti-inflammatory properties. This study investigated the therapeutic effect of salvianolic acids on chronic mild stress (CMS)-induced depressive-like behaviors in rats and the involvement of toll-like receptor 4 ...
Fengya Zhen, Lulu Yu, Lan Wang, Shuo Wang, Wenting Lu, Xueyi Wang, Cuixia An   +6 more
doaj   +1 more source

Saturated fatty acids enhance osteoclast survival

Journal of Lipid Research, 2010
Hyperlipidemia and marrow fat are associated with lowering bone density in vivo, suggesting that lipid contributes to bone loss. Using bone marrow–derived macrophages, we investigated the effect of saturated fatty acids (SFA) on osteoclastogenesis.
So-Ra Oh, Ok-Joo Sul, Youn-Young Kim, Hye-Jin Kim, Rina Yu, Jae-Hee Suh, Hye-Seon Choi   +6 more
doaj   +1 more source

HoxA9 binds and represses the Cebpa +8 kb enhancer [PDF]

, 2019
C/EBPα plays a key role in specifying myeloid lineage development. HoxA9 is expressed in myeloid progenitors, with its level diminishing during myeloid maturation, and HOXA9 is over-expressed in a majority of acute myeloid leukemia cases, including those
Aplan, Peter D., Dennison, Lauren, Friedman, Alan D., Guo, Hong, Hess, Jay L., Ma, Peilin, Peng, Lei, Sun, Yuqing   +7 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Hepatitis C Virus and Hepatocellular Carcinoma: Pathogenetic Mechanisms and Impact of Direct-Acting Antivirals [PDF]

, 2018
INTRODUCTION: Globally, between 64 and 103 million people are chronically infected with Hepatitis C virus (HCV), with more than 4.6 million people in the United States and is associated with more than 15.000 deaths annually.
Petruzziello, Arnolfo, Pinacchio, Claudia, Scheri, Giuseppe Corano, Schietroma, Ivan, Statzu, Maura, Vullo, Vincenzo   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source