Results 11 to 20 of about 1,794 (168)

Protective Effect of Edaravone Against Oxidative Stress in C2C12 Myoblast and Impairment of Skeletal Muscle Regeneration Exposed to Ischemic Injury in Ob/ob Mice

Frontiers in Physiology, 2020
BackgroundThe aims of this study were to analyze the effects of the administration of edaravone on C2C12 myoblasts exposed to oxidative stress; to evaluate the skeletal muscles in ob/ob mice; and to analyze the effect of the administration of edaravone ...
Takuya Nakanishi, Masaya Tsujii, Takahiro Asano, Takahiro Iino, Akihiro Sudo   +4 more
doaj   +1 more source

The ensured proliferative capacity of myoblast in serum-reduced conditions with Methyl-β-cyclodextrin

Frontiers in Cell and Developmental Biology, 2023
To produce muscle fibers for cultured meat on a large scale, it is important to expand myoblasts in a serum-reduced or serum-free medium to avoid cost, ethical, and environmental issues.
Tomoka Katayama, Yuta Chigi, Daiji Okamura   +2 more
doaj   +1 more source

Omega-3 Polyunsaturated Fatty Acids Mitigate Palmitate-Induced Impairments in Skeletal Muscle Cell Viability and Differentiation

Frontiers in Physiology, 2020
Accumulation of excess saturated free fatty acids such as palmitate (PAL) in skeletal muscle leads to reductions in mitochondrial integrity, cell viability and differentiation. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) such as eicosapentaenoic acid
Bill Tachtsis, Jamie Whitfield, John A. Hawley, Nolan J. Hoffman   +3 more
doaj   +1 more source

RNA-Sequencing Reveals Upregulation and a Beneficial Role of Autophagy in Myoblast Differentiation and Fusion

Cells, 2022
Myoblast differentiation is a complex process whereby the mononuclear muscle precursor cells myoblasts express skeletal-muscle-specific genes and fuse with each other to form multinucleated myotubes.
Pengcheng Lyu, Honglin Jiang
doaj   +1 more source

Circular RNA circ-FoxO3 Inhibits Myoblast Cells Differentiation

Cells, 2019
CircRNA is a type of closed circular non-coding RNA formed by reverse splicing and plays an important role in regulating the growth and development of plants and animals.
Xiaoyue Li, Cunyuan Li, Zhijin Liu, Wei Ni, Rui Yao, Yueren Xu, Renzhe Quan, Mengdan Zhang, Huixiang Li, Li Liu, Shengwei Hu   +10 more
doaj   +1 more source

IL-1β and TNF-α Modulation of Proliferated and Committed Myoblasts: IL-6 and COX-2-Derived Prostaglandins as Key Actors in the Mechanisms Involved

Cells, 2020
In this study, we investigated the effects and mechanisms of the pro-inflammatory cytokines IL-1β and TNF-α on the proliferation and commitment phases of myoblast differentiation.
Angela M. Alvarez, Carlos DeOcesano-Pereira, Catarina Teixeira, Vanessa Moreira   +3 more
doaj   +1 more source

Understanding the Effects of Trenbolone Acetate, Polyamine Precursors, and Polyamines on Proliferation, Protein Synthesis Rates, and the Abundance of Genes Involved in Myoblast Growth, Polyamine Biosynthesis, and Protein Synthesis in Murine Myoblasts

Biology, 2023
Research suggests that androgens increase skeletal muscle growth by modulating polyamine biosynthesis. As such, the objective of this study was to investigate effects of anabolic hormones, polyamine precursors, and polyamines relative to proliferation ...
Laura A. Motsinger, Lillian L. Okamoto, Nikole E. Ineck, Brynne A. Udy, Christopher L. Erickson, Youssef Harraq, Caleb C. Reichhardt, Gordon K. Murdoch, Kara Jean Thornton   +8 more
doaj   +1 more source

LKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiation.

PLoS ONE, 2012
BackgroundSkeletal muscle myoblast differentiation and fusion into multinucleate myotubes is associated with dramatic cytoskeletal changes. We find that microtubules in differentiated myotubes are highly stabilized, but premature microtubule ...
Isma Mian, Willythssa Stéphie Pierre-Louis, Neha Dole, Renée M Gilberti, Kimberly Dodge-Kafka, Jennifer S Tirnauer   +5 more
doaj   +1 more source

Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep

Frontiers in Physiology, 2022
IGF-1 is a critical fetal growth-promoting hormone. Experimental infusion of an IGF-1 analog, human recombinant LR3 IGF-1, into late gestation fetal sheep increased fetal organ growth and skeletal muscle myoblast proliferation.
J Stremming, A White, A Donthi, DG Batt, B Hetrick, EI Chang, SR Wesolowski, MB Seefeldt, CE McCurdy, PJ Rozance, LD Brown   +10 more
doaj   +1 more source

A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts

Skeletal Muscle, 2012
Background The p38α mitogen-activated protein kinase (MAPK) is a critical mediator of myoblast differentiation, and does so in part through the phosphorylation and regulation of several transcription factors and chromatin remodelling proteins.
Knight James DR, Tian Ruijun, Lee Robin EC, Wang Fangjun, Beauvais Ariane, Zou Hanfa, Megeney Lynn A, Gingras Anne-Claude, Pawson Tony, Figeys Daniel, Kothary Rashmi   +10 more
doaj   +1 more source