Results 111 to 120 of about 691,224 (357)

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

Trimetazidine in coronary heart disease patients: mechanism of action and controlled trials’ results

Кардиоваскулярная терапия и профилактика, 2005
Metabolic cardioprotection is an important part of treating patients with coronary heart disease (CHD). The most widely used drug in this group is trimetazidine.
L. V. Kremneva, O. V. Abaturova, S. V. Shalaev   +2 more
doaj  

Salvia miltiorrhiza treatment during early reperfusion reduced postischemic myocardial injury in the rat [PDF]

, 2007
Oxidative stress may play a causative role in myocardial ischemia-reperfusion injury. However, it is a relatively understudied aspect regarding an optimal timing of antioxidant intervention during ischemia-reperfusion.
Nie, R, Xia, R, Xia, Z, Zhong, X
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Myocardial Viability: From Proof of Concept to Clinical Practice

Cardiology Research and Practice, 2016
Ischaemic left ventricular (LV) dysfunction can arise from myocardial stunning, hibernation, or necrosis. Imaging modalities have become front-line methods in the assessment of viable myocardial tissue, with the aim to stratify patients into optimal ...
Aditya Bhat, Gary C. H. Gan, Timothy C. Tan, Chijen Hsu, Alan Robert Denniss   +4 more
doaj   +1 more source

Early predictors of left ventricular function improvement late after myocardial infarction [PDF]

, 2008
Background/Aim. Prognosis after acute myocardial infarction (AIM) depends on the extent of irreversibly damaged myocardium and viable tissue due to stunning or hibernation.
Angelkov-Ristić Anđelka, Gligić Branko, Jovelić Aleksandra, Kalimanovska-Oštrić Dimitra, Mijailović Zdravko, Mladenović Zorica, Obradović Slobodan, Tavčiovski Dragan   +7 more
core   +1 more source

Forecasting heart failure: Seasonal alignment of heart failure outcomes in New York

ESC Heart Failure, Volume 12, Issue 2, Page 819-831, April 2025.
Abstract Background Seasonal variations have been observed in heart failure (HF) hospitalization. Numerous explanatory mechanisms have been proposed, but no prior studies have examined potential contributors directly. Our objective was to identify specific factors that could contribute to seasonal variability using a large longitudinal dataset of HF ...
Prerna Gupta, Ellen Brinza, Prateeti Khazanie, Pamela N. Peterson, P Michael Ho, David P. Kao   +5 more
wiley   +1 more source

Takotsubo Cardiomyopathy Mimicking Stent Thrombosis After Percutaneous Coronary Intervention

Journal of Investigative Medicine High Impact Case Reports, 2018
Takotsubo cardiomyopathy, also known as “broken heart syndrome,” is a transient left ventricular dysfunction associated with stress (usually emotional) induced myocardial injury and stunning.
Furqan Khattak MD, Muhammad Khalid MD, Ghulam Murtaza MD, Timir K. Paul MD, PhD   +3 more
doaj   +1 more source

Anesthesia Management for a Patient Undergoing Pulmonary Endarterctomy without Cardiopulmonary Bypass [PDF]

Brazilian Journal of Cardiovascular Surgery
Pulmonary endarterectomy is a curative procedure for chronic thromboembolic Pulmonary Hypertension. As usual, cardiopulmonary bypass circuit is required. However, there are several complications attributed to extracorporeal circulation.
Ayten Saracoglu, Onur Ermerak, Esra Yaman Savci Sirzai, Mustafa Yuksel, Zuhal Aykac, Bedrettin Yildizeli   +5 more
doaj   +2 more sources

Effects of angiotensin-I and ischemia on functional recovery in isolated hearts [PDF]

, 2011
FUNDAMENTO: A ressuscitação de parada cardíaca pode apresentar disfunção miocárdica determinada pelo tempo da isquemia, e a inibição da enzima conversora de angiotensina (ECA) pode reduzir a disfunção cardíaca durante a reperfusão.
IRIGOYEN, Maria Claudia, KUCHARSKI, Luiz Carlos, MACHADO, Ubiratan Fabres, OLIVEIRA, Ubirajara Oliveira de, OLIVEIRA, Álvaro Reischak de, SCHAAN, Beatriz D'Agord   +5 more
core   +3 more sources