The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes [PDF]
eLife, 2017 Altered Ca2+ handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. However, whether Ca2+ directly regulates sarcomere structure has remained elusive.
Hirohito Shimizu +7 more
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What Can We Learn from Single Sarcomere and Myofibril Preparations?
Frontiers in Physiology, 2022 Sarcomeres are the smallest functional contractile unit of muscle, and myofibrils are striated muscle organelles that are comprised of sarcomeres that are strictly aligned in series.
Walter Herzog
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HDAC6 modulates myofibril stiffness and diastolic function of the heart
The Journal of Clinical Investigation, 2022 Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin ...
Ying-Hsi Lin +18 more
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Frontiers in Cardiovascular Medicine, 2019 Myofibril based mechanical studies allow evaluation of sarcomeric protein function. We describe a novel method of obtaining myofibrils from primary cardiomyocyte culture.
Kathleen C. Woulfe +10 more
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Characterizing the actin-binding ability of Zasp52 and its contribution to myofibril assembly.
PLoS ONE, 2020 In sarcomeres, α-actinin crosslinks thin filaments and anchors them at the Z-disc. Drosophila melanogaster Zasp52 also localizes at Z-discs and interacts with α-actinin via its extended PDZ domain, thereby contributing to myofibril assembly and ...
Kuo An Liao +2 more
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Frontiers in Physiology, 2021 Resistance training increases muscle fiber hypertrophy, but the morphological adaptations that occur within muscle fibers remain largely unresolved.
Bradley A. Ruple +17 more
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Expression and functional characterization of Smyd1a in myofibril organization of skeletal muscles. [PDF]
PLoS ONE, 2014 BACKGROUND:Smyd1, the founding member of the Smyd family including Smyd-1, 2, 3, 4 and 5, is a SET and MYND domain containing protein that plays a key role in myofibril assembly in skeletal and cardiac muscles.
Jie Gao +5 more
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Myofibril diameter is set by a finely tuned mechanism of protein oligomerization in Drosophila
eLife, 2019 Myofibrils are huge cytoskeletal assemblies embedded in the cytosol of muscle cells. They consist of arrays of sarcomeres, the smallest contractile unit of muscles.
Nicanor González-Morales +5 more
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A novel imaging method (FIM-ID) reveals that myofibrillogenesis plays a major role in the mechanically induced growth of skeletal muscle [PDF]
eLifeAn increase in mechanical loading, such as that which occurs during resistance exercise, induces radial growth of muscle fibers (i.e. an increase in cross-sectional area).
Kent W Jorgenson +10 more
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Architecture and molecular machinery of skeletal myofibers: a systematic review of the structure–function relationships [PDF]
Frontiers in Cell and Developmental BiologyThe skeletal muscle, one of the largest tissues in mammals, plays a crucial role in maintaining body movement and energy metabolism. Dysfunction or damage to the skeletal muscle can lead to various muscle diseases, such as muscular dystrophy, myasthenia,
Jing Zhao +4 more
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