Results 1 to 10 of about 34,282 (300)
The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes [PDF]
eLife, 2017 Altered Ca2+ handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. However, whether Ca2+ directly regulates sarcomere structure has remained elusive.
Hirohito Shimizu +7 more
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Cardiomyocyte Hypocontractility and Reduced Myofibril Density in End-Stage Pediatric Cardiomyopathy [PDF]
Frontiers in Physiology, 2017 Dilated cardiomyopathy amongst children (pediatric cardiomyopathy, pediatric CM) is associated with a high morbidity and mortality. Because little is known about the pathophysiology of pediatric CM, treatment is largely based on adult heart failure ...
Ilse A. E. Bollen +6 more
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What Can We Learn from Single Sarcomere and Myofibril Preparations?
Frontiers in Physiology, 2022 Sarcomeres are the smallest functional contractile unit of muscle, and myofibrils are striated muscle organelles that are comprised of sarcomeres that are strictly aligned in series.
Walter Herzog
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Peptic digestion of beef myofibrils is modified by prior marination
Food & Nutrition Research, 2013 Background: Preparatory steps such as seasoning, marination, and cooking may induce changes in meat which affects the ability of the stomach to adequately digest it.
Nash Patel, Simon J. M. Welham
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Measurement of Calcium Dissociation Rates from Troponin C in Rigor Skeletal Myofibrils [PDF]
Frontiers in Physiology, 2011 Ca2+ dissociation from the regulatory domain of troponin C may influence the rate of striated muscle relaxation. However, Ca2+ dissociation from troponin C has not been measured within the geometric and stoichiometric constraints of the muscle fiber ...
Sean C Little +4 more
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The role of sarcomere length non-uniformities in residual force enhancement of skeletal muscle myofibrils [PDF]
Royal Society Open Science, 2016 The sarcomere length non-uniformity theory (SLNT) is a widely accepted explanation for residual force enhancement (RFE). RFE is the increase in steady-state isometric force following active muscle stretching. The SLNT predicts that active stretching of a
Kaleena Johnston +2 more
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Biology, 2022 The R249Q mutation in human β-cardiac myosin results in hypertrophic cardiomyopathy. We previously showed that inserting this mutation into Drosophila melanogaster indirect flight muscle myosin yields mechanical and locomotory defects.
William A. Kronert +5 more
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The Structural Adaptations That Mediate Disuse-Induced Atrophy of Skeletal Muscle
Cells, 2023 The maintenance of skeletal muscle mass plays a fundamental role in health and issues associated with quality of life. Mechanical signals are one of the most potent regulators of muscle mass, with a decrease in mechanical loading leading to a decrease in
Ramy K. A. Sayed +3 more
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eLife, 2023 Sarcomeres are the basic contractile units within cardiac myocytes, and the collective shortening of sarcomeres aligned along myofibrils generates the force driving the heartbeat.
Abigail C Neininger-Castro +7 more
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eLife, 2021 Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth.
Aynur Kaya-Çopur +9 more
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