Results 11 to 20 of about 34,282 (300)
HDAC6 modulates myofibril stiffness and diastolic function of the heart
The Journal of Clinical Investigation, 2022 Passive stiffness of the heart is determined largely by extracellular matrix and titin, which functions as a molecular spring within sarcomeres. Titin stiffening is associated with the development of diastolic dysfunction (DD), while augmented titin ...
Ying-Hsi Lin +18 more
doaj +2 more sources
Mechanobiology of muscle and myofibril morphogenesis.
Cells & Development, 2021 Muscles generate forces for animal locomotion. The contractile apparatus of muscles is the sarcomere, a highly regular array of large actin and myosin filaments linked by gigantic titin springs. During muscle development many sarcomeres assemble in series into long periodic myofibrils that mechanically connect the attached skeleton elements.
N. M. Luis, F. Schnorrer
semanticscholar +3 more sources
Frontiers in Cardiovascular Medicine, 2019 Myofibril based mechanical studies allow evaluation of sarcomeric protein function. We describe a novel method of obtaining myofibrils from primary cardiomyocyte culture.
Kathleen C. Woulfe +10 more
doaj +2 more sources
Frontiers in Physiology, 2021 Resistance training increases muscle fiber hypertrophy, but the morphological adaptations that occur within muscle fibers remain largely unresolved.
Bradley A. Ruple +17 more
doaj +2 more sources
Characterizing the actin-binding ability of Zasp52 and its contribution to myofibril assembly.
PLoS ONE, 2020 In sarcomeres, α-actinin crosslinks thin filaments and anchors them at the Z-disc. Drosophila melanogaster Zasp52 also localizes at Z-discs and interacts with α-actinin via its extended PDZ domain, thereby contributing to myofibril assembly and ...
Kuo An Liao +2 more
doaj +2 more sources
Expression and functional characterization of Smyd1a in myofibril organization of skeletal muscles. [PDF]
PLoS ONE, 2014 BACKGROUND:Smyd1, the founding member of the Smyd family including Smyd-1, 2, 3, 4 and 5, is a SET and MYND domain containing protein that plays a key role in myofibril assembly in skeletal and cardiac muscles.
Jie Gao +5 more
doaj +2 more sources
Myofibril diameter is set by a finely tuned mechanism of protein oligomerization in Drosophila
eLife, 2019 Myofibrils are huge cytoskeletal assemblies embedded in the cytosol of muscle cells. They consist of arrays of sarcomeres, the smallest contractile unit of muscles.
Nicanor González-Morales +5 more
doaj +2 more sources
Force Measurements From Myofibril to Filament [PDF]
Frontiers in Physiology, 2022 Contractility, the generation of force and movement by molecular motors, is the hallmark of all muscles, including striated muscle. Contractility can be studied at every level of organization from a whole animal to single molecules.
Steven Marston
doaj +5 more sources
Alp/Enigma family proteins cooperate in Z-disc formation and myofibril assembly. [PDF]
PLoS Genetics, 2013 The Drosophila Alp/Enigma family protein Zasp52 localizes to myotendinous junctions and Z-discs. It is required for terminal muscle differentiation and muscle attachment.
Anja Katzemich +3 more
doaj +2 more sources
Frontiers in Physiology, 2017 Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease (CHD).
Madeline Midgett +5 more
doaj +2 more sources