Results 51 to 60 of about 2,944 (198)

A novel imaging method (FIM-ID) reveals that myofibrillogenesis plays a major role in the mechanically induced growth of skeletal muscle

eLife
An increase in mechanical loading, such as that which occurs during resistance exercise, induces radial growth of muscle fibers (i.e. an increase in cross-sectional area).
Kent W Jorgenson, Jamie E Hibbert, Ramy KA Sayed, Anthony N Lange, Joshua S Godwin, Paulo HC Mesquita, Bradley A Ruple, Mason C McIntosh, Andreas N Kavazis, Michael D Roberts, Troy A Hornberger   +10 more
doaj   +1 more source

Measurement of Calcium Dissociation Rates from Troponin C in Rigor Skeletal Myofibrils

Frontiers in Physiology, 2011
Ca2+ dissociation from the regulatory domain of troponin C may influence the rate of striated muscle relaxation. However, Ca2+ dissociation from troponin C has not been measured within the geometric and stoichiometric constraints of the muscle fiber ...
Sean C Little, Svetlana B Tikunova, Darl R. Swartz, Catalina eNorman, Jonathan P Davis   +4 more
doaj   +1 more source

A multisegmental cross-bridge kinetics model of the myofibril.

, 2009
Striated muscle is a mechanical system that develops force and generates power in serving vital activities in the body. Striated muscle is a complex biological system; a single mammalian muscle fibre contains up to hundred or even more myofibrils in ...
Stüssi E, Stoecker U, Denoth J, Telley IA   +3 more
core   +1 more source

From muscle fibres to muscle gears: how dynamic fascicle orientation and shape change impact skeletal muscle function

Biological Reviews, EarlyView.
ABSTRACT Skeletal muscle architectural design strongly affects force‐generating capacity and excursion range, and its functional importance to animal and human movement is well founded. Traditionally, this ‘structure–function relation’ has been inferred from architecture measurements with muscles at rest (from anatomical dissections or medical imaging ...
Matheus D. Pinto, James M. Wakeling, Javier A. Almonacid, Anthony J. Blazevich   +3 more
wiley   +1 more source

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

Microtubules coordinate mitochondria transport with myofibril morphogenesis during muscle development

Muscle morphogenesis creates highly specialised muscle cells containing contractile myofibrils and energy producing mitochondria. Myofibrils are chains of sarcomeres, whose myosin motors slide over actin filaments at the expense of ATP.
Gomes, Edgar, R, Candeias, Duarte, Avellaneda, Jerome, Schnorrer, Frank, da Rosa Soares, Ana, Luis, Nuno, Miguel   +5 more
core   +2 more sources

Perturbation of cytosolic calcium by 2-aminoethoxydiphenyl borate and caffeine affects zebrafish myofibril alignment

, 2015
The objective of the current study was to investigate the effects of Ca2+ levels on myofibril alignment during zebrafish embryogenesis. To investigate how altered cytoplasmic Ca2+ levels affect myofibril alignment, we exposed zebrafish embryos to 2 ...
Yun‐Hsin Wang, I‐Jong Wang, Shen‐Liang Chen, Jen‐Cheng Wei, Hsin‐Ju Wu, Tsorng‐Harn Fong, Chen, Yau-hung, Wang, Yun-hsin, Juin‐Lin Horng, Xing‐Guang Chen, Hui‐Min Chen, Chi‐Chung Wen, Wei‐Yu Chen, Chao‐Yuan Chang, Yau‐Hung Chen   +14 more
core   +1 more source

Assembly and Maintenance of Myofibrils in the Heart

Cytoskeleton, EarlyView.
ABSTRACT The assembly of actin and myosin to the paracrystalline arrangement of myofibrils in striated muscle, that is, heart and skeletal, has puzzled many a cell biologist. Different models, based on cultured cardiomyocytes, were proposed for the last 30 years to explain the sequence of events.
Elisabeth Ehler
wiley   +1 more source

Talin Is Required Continuously for Cardiomyocyte Remodeling during Heart Growth in Drosophila. [PDF]

PLoS ONE, 2015
Mechanotransduction of tension can govern the remodeling of cardiomyocytes during growth or cardiomyopathy. Tension is signaled through the integrin adhesion complexes found at muscle insertions and costameres but the relative importance of signalling ...
Simina Bogatan, Duygu Cevik, Valentin Demidov, Jessica Vanderploeg, Abdullah Panchbhaya, Alex Vitkin, J Roger Jacobs   +6 more
doaj   +1 more source

Force Measurements From Myofibril to Filament

Frontiers in Physiology, 2022
Contractility, the generation of force and movement by molecular motors, is the hallmark of all muscles, including striated muscle. Contractility can be studied at every level of organization from a whole animal to single molecules.
Steven Marston
doaj   +1 more source