Results 81 to 90 of about 33,732 (260)

The Regulation of Muscle Structure and Metabolism by Mio/dChREBP in Drosophila. [PDF]

PLoS ONE, 2015
All cells require energy to perform their specialized functions. Muscle is particularly sensitive to the availability of nutrients due to the high-energy requirement for muscle contraction.
Grzegorz L Polak, Anthony Pasqualino, James E B Docherty, Stephen J Beck, Justin R DiAngelo   +4 more
doaj   +1 more source

Association of Calpastatin (CAST) Gene with Growth Traits and Carcass Characteristics in Bali Cattle [PDF]

, 2015
Calpastatin (CAST) gene is well known as an inhibitor of muscle protein degradation and relates to muscle growth and meat tenderness. The objective of this study was to determine the association of CAST gene with growth traits and carcass characteristics
Gunawan, A. (A), Jakaria, J. (Jakaria), Priyanto, R. (R), Putri, R. (R)   +3 more
core  

Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. [PDF]

, 2017
Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes involved in excitation-contraction coupling for power of contraction. Little is known about how T-tubules maintain highly organized structures and contacts throughout
Fujita, Naonobu, Fukuda, Mitsunori, Groulx, Jean-Francois, Huang, Wilson, Jean, Steve, Kiger, Amy A, Koyama-Honda, Ikuko, Kuchitsu, Yoshihiko, Lin, Tzu-Han, Mizushima, Noboru, Nguyen, Jen   +10 more
core   +2 more sources

Pharmacological Inhibition of β Myosin II Disrupts Sarcomere Assembly in Human iPSC‐Derived Cardiac Myocytes

Cytoskeleton, EarlyView.
ABSTRACT Sarcomeres are the fundamental contractile units of striated muscle. The functional roles of the cardiac‐specific myosin heavy chains, MYH6 (α myosin II) and MYH7 (β myosin II) during sarcomere assembly remain controversial. To address this, we utilized a selective MYH7 inhibitor, mavacamten, in combination with siRNA‐mediated knockdown of ...
James B. Hayes, Dylan T. Burnette
wiley   +1 more source

Alterations in thin filament length during postnatal skeletal muscle development and aging in mice

Frontiers in Physiology, 2014
The lengths of the sarcomeric thin filaments vary in a skeletal muscle-specific manner and help specify the physiological properties of skeletal muscle.
David S Gokhin, Emily A Dubuc, Kendra Q Lian, Luanne L Peters, Velia M Fowler   +4 more
doaj   +1 more source

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

Surface plasmon resonance study of the actin-myosin sarcomeric complex and tubulin dimers

, 2003
Biosensors based on the principle of surface plasmon resonance (SPR) detection were used to measure biomolecular interactions in sarcomeres and changes of the dielectric constant of tubulin samples with varying concentration.
Alexander A. Kolomenskii, Andreas Mershin, Brekhovskikh L. M., Brown J. A., Dimitri V. Nanopoulos, Earp R. L., Hans A. Schuessler, Mershin A., Raether H.   +8 more
core   +1 more source

Cardiac manifestations of PRKAG2 mutation. [PDF]

, 2018
BACKGROUND:The Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2 (PRKAG2) cardiac syndrome is characterized by glycogen accumulation in the cardiac tissue.
Ardehali, Reza, Banankhah, Pooya, Dota, Anthony, Fishbein, Gregory A   +3 more
core   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes [PDF]

, 2015
Spatio-temporal dynamics of intracellular calcium, [Ca2+]i, regulate the contractile function of cardiac muscle cells. Measuring [Ca2+]i flux is central to the study of mechanisms that underlie both normal cardiac function and calcium-dependent ...
A Baddeley, A Hatano, A Hatano, A Zahradnikova, AM Katz, Amorita Petzer, Anthony Hickey, AT Roe, AW Trafford, B Sportisse, BD Ripley, C Bradley, C Pinali, C Pinali, C Soeller, C Soeller, C Soeller, C Soeller, Cameron G. Walker, Christian Soeller, D Baddeley, D Baddeley, D Eisner, Daniel A Beard, David J. Crossman, DJ Greensmith, DM Bers, DM Bers, DR Laver, E Picht, E Theakston, EA Sobie, Edmund J. Crampin, F Brette, F Brette, F Legros, FR Heinzel, GD Smith, Gregory Bass, GSB Williams, GSB Williams, H Si, ID Jayasinghe, ID Jayasinghe, ID Jayasinghe, II Dorn, Ivo Siekmann, J Hake, J Hake, J Illian, J Moller, J Okada, JR Kremer, K Gusev, L Biesmans, L Boyman, L Zhang, LS Song, LS Song, LT Izu, M Vendelin, Mark H. Ellisman, Masahiko Hoshijima, MB Cannell, MD Stern, MD Stern, MH Ellisman, PC Bressloff, PM Kekenes-Huskey, R Turner, S Svensson, S-Q Wang, T Das, T Hayashi, T Hong, V Piacentino, Vijay Rajagopal, WE Louch, X Lu, Y Cheng, Y Hou   +80 more
core   +6 more sources