Results 111 to 120 of about 21,460 (265)

The mitochondrial‐targeted antioxidant SkQ1 prevents skeletal muscle mitochondrial‐apoptotic but not necroptotic signalling during ovarian cancer

The Journal of Physiology, EarlyView.
Abstract figure legend An evaluation of the degree to which mitochondrial hydrogen peroxide emission (mH2O2)‐mediated apoptotic and necroptotic signalling contributes to skeletal muscle atrophy in an orthotopic epithelial ovarian cancer (EOC) model. To determine whether attenuating mH2O2 could prevent regulated cell death signalling and mitigate muscle
Shahrzad Khajehzadehshoushtar, Luca J. Delfinis, Fasih A. Rahman, Madison C. Garibotti, Shivam Gandhi, Aditya N. Brahmbhatt, Brooke A. Morris, Bianca Garlisi, Sylvia Lauks, Caroline Aitken, Leslie Ogilvie, Zhu‐Xu Zhang, Jeremy A. Simpson, Joe Quadrilatero, Jim Petrik, Christopher G. R. Perry   +15 more
wiley   +1 more source

An exploration of the methods to determine the protein‐specific synthesis and breakdown rates in vivo in humans

Physiological Reports, 2019
The present study explores the methods to determine human in vivo protein‐specific myofibrillar and collagenous connective tissue protein fractional synthesis and breakdown rates.
Lars Holm, Kasper Dideriksen, Rie H. Nielsen, Simon Doessing, Rasmus L. Bechshoeft, Grith Højfeldt, Marcus Moberg, Eva Blomstrand, Søren Reitelseder, Gerrit vanHall   +9 more
doaj   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism

Journal of Cachexia, Sarcopenia and Muscle
Background Bed‐rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same ...
Natalie F. Shur, Elizabeth J. Simpson, Hannah Crossland, Despina Constantin, Sally M. Cordon, Dumitru Constantin‐Teodosiu, Francis B. Stephens, Matthew S. Brook, Philip J. Atherton, Kenneth Smith, Daniel J. Wilkinson, Olivier E. Mougin, Christopher Bradley, Ian A. Macdonald, Paul L. Greenhaff   +14 more
doaj   +1 more source

Atrial fibrosis in atrial fibrillation: Mechanisms, mapping techniques and clinical applications

The Journal of Physiology, EarlyView.
Abstract figure legend Summary of key aspects of atrial fibrosis in atrial fibrillation, highlighting atrial fibrosis as a hallmark of atrial fibrillation (AF). (1) Different types of fibrosis (blue), illustrating reparative and reactive fibrosis; (2) fibrosis detection techniques (green), illustrating late gadolinium enhancement cardiac magnetic ...
Caterina Vidal Horrach, Laura Bevis, Cynthia Nwanna, Alexander M Zolotarev, Mahmoud Ehnesh, Semhar Biniam Misghina, Sayed Al‐Aidarous, Shohreh Honarbakhsh, Caroline H. Roney   +8 more
wiley   +1 more source

Suppression of Myofibrillar Protein Degradation after Refeeding in Young and Adult Mice [PDF]

, 2004
A diet containing adequate amounts of protein rapidly suppresses myofibrillar protein degradation after refeeding in young rats and mice. However, it is unclear whether this suppression is seen in adult animals.
YOSHIZAWA, Fumiaki, ITO, Yoshiaki, KIKUCHI, Nobuhiro, NAGASAWA, Takashi, NISHIZAWA, Naoyuki   +4 more
core  

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Myofibrillar Protein Status of the Gastrocnemius in Male Rats: Effect of Mild Undernutrition

, 2006
The aim of this work was the determination of the myofibrillar protein profiles in the fed and the mildly underfed rat. Sixteen male rats were divided into 2 groups: CR (control) fed ad libitum and MR (mildly undernourished) fed 75% of energetic ...
Almeida, A M, Cardoso, L A, van Harten, S   +2 more
core   +1 more source

Resistance training load does not determine resistance training‐induced hypertrophy across upper and lower limbs in healthy young males

The Journal of Physiology, EarlyView.
Abstract figure legend In healthy young males, we found that skeletal muscle hypertrophy following a period of resistance exercise training (RET) was consistent within and between subjects, as assessed using a variety of established methods. The skeletal muscle hypertrophic response was independent of external load.
Matthew J. Lees, Jonathan C. Mcleod, Robert W. Morton, Brad S. Currier, Matthew D. Fliss, Sean R. McKellar, Rajbir S. Sidhu, Ben N. Stansfield, Erin K. Webb, Chris McGlory, Jatin G. Burniston, Stuart M. Phillips   +11 more
wiley   +1 more source

Contraction-induced changes in TNFα and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle

, 2010
Resistance training results in skeletal muscle hypertrophy, but the molecular signalling mechanisms responsible for this altered phenotype are incompletely understood.
Yaspelkis III, Benjamin B., Reeder, Donald W., Hawley, John A., Lancaster, Graeme I., Karagounis, Leonidas G., Coffey, Vernon G.   +5 more
core   +1 more source