Results 141 to 150 of about 21,460 (265)

Cancer IDO1‐Mediated Tryptophan–Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3‐dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is often upregulated in cancers, but its specific role in driving lung cancer–associated ...
Leng Han, Lingjie Jing, Xinting Zhu, Ciqin Li, Lu Bai, Yang Fang, Yuxuan Zhou, Dingyuan Bai, Jin Lu, Yonglong Han, Cheng Guo, Shumin Zhou, Quanjun Yang   +12 more
wiley   +1 more source

Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage

, 2016
Filamin c (FLNc) is a large dimeric actin-binding protein located at premyofibrils, myofibrillar Z-discs and myofibrillar attachment sites of striated muscle cells, where it is involved in mechanical stabilization, mechanosensation and intracellular ...
van der Ven, Peter F. M., Bryson-Richardson, Robert J., Fürst, Dieter O., Leber, Yvonne, Kirfel, Gregor, Ruparelia, Avnika A., Hoffmann, Bernd, Merkel, Rudolf   +7 more
core   +1 more source

Deubiquitinase YOD1 Inhibition Suppresses DEX‐ and Denervation‐Induced Muscle Atrophy Through MAFbx Destabilization

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Backgrounds Muscle atrophy, characterized by progressive loss of muscle mass and function, is driven by muscle‐specific E3 ligases MAFbx and MuRF1. While transcriptional regulation of E3 ligases is documented, the mechanism of their regulation by the ubiquitin–proteasome system remains unclear. This study aims to identify a deubiquitinase (DUB)
Jongbeom Chae, Seon Min Woo, Seung Un Seo, Simmyung Yook, Hyo Je Cho, Jung Yeol Lee, Kyoung jin Min, Junhyeon Park, Dongryeol Ryu, Taeg Kyu Kwon   +9 more
wiley   +1 more source

Myofibrillar protein and gene expression in acute quadriplegic myopathy

, 2009
The dramatic muscle wasting, preferential loss of myosin and impaired   muscle function in intensive care unit (ICU) patients with acute   quadriplegic myopathy (AQM) have traditionally been suggested to be the   result of proteolysis via specific ...
Zahrisson, Håkan, Libelius, Rolf,, Libelius, R, Larsson, L,, Eriksson, Lars I, Norman, Holly, Nordquist, Jenny,, Hedstrom, Y, Norman, H, Larsson, Lars,, Eriksson, LI, Nordquist, J, Andersson, Per,, Larsson, Lars, Libelius, Rolf, Norman, Holly,, Zackrisson, Håkan, Andersson, P, Hedström, Yvette,, Hedström, Yvette, Andersson, Per, Nordquist, Jenny, Zackrisson, H   +22 more
core   +1 more source

Elevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Ceramides have garnered considerable attention as pro‐aging bioactive lipids implicated in both metabolic dysfunction and musculoskeletal decline. Among these, C18:0 and C24:1 ceramides may play a role in the pathophysiology of sarcopenia, a key manifestation of age‐related deterioration.
So Jeong Park, Ji Yeon Baek, Shibo Wei, Jin Young Lee, Yuna Lee, Sang‐Hoon Lee, Il‐Young Jang, Hyuk Sakong, Hyun Ju Yoo, Hee‐Won Jung, Eunju Lee, Su Jung Kim, Yunju Jo, Kyunggon Kim, Dongryeol Ryu, Beom‐Jun Kim   +15 more
wiley   +1 more source

RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4‐Mediated Mitochondrial Restoration and Inflammation Suppression

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Peripheral nerve injury‐induced muscle atrophy shares core pathophysiological features with systemic wasting disorders including cachexia and sarcopenia, yet early molecular triggers remain undefined. This study investigates the pathogenic role of receptor‐interacting protein kinase 3 (RIPK3) in denervation atrophy.
Yuntian Shen, Chen Zhang, Zihao Zhao, Jia Yi, Xinlei Yao, Bingqian Chen, Hualin Sun   +6 more
wiley   +1 more source

A novel oral tracer procedure for measurement of habitual myofibrillar protein synthesis

, 2013
RATIONALE: Conventionally, myofibrillar protein synthesis is measured over time periods of hours. In clinical studies, interventions occur over weeks. Functional measures over such periods may be more representative.
Stephens, N. A., Ross, J.A., Preston, T., Small, A. C., MacDonald, A.J., Stephens, N.A., Ross, J. A., Fearon, K.C.H., Greig, C. A.; id_orcid, Greig, C.A., Husi, H., Small, A.C., Macdonald, A. J., Fearon, K. C.H.   +13 more
core   +1 more source

Structural Changes of Myofibrillar Proteins in Marinated Duck Drumsticks during Ultra-high Pressure Processing Treatment

Shipin gongye ke-ji
To investigate the improvement mechanism of ultra-high pressure treatment on the tenderness of marinated duck drumsticks, this study analyzed the pattern of structural changes of myofibrillar proteins during ultra-high pressure processing (400 MPa, 15 ...
Jingjiu LI, Mingfei SONG, Yue NIU, Lingjiao ZHU, Danjun GUO, Wei XU, Yang YI, Hongxun WANG   +7 more
doaj   +1 more source

Main effects of ascorbic acid levels and organic acid type on physicochemical properties, microbial populations, texture, and biogenic amine formation in sucuk

Journal of the Science of Food and Agriculture, Volume 106, Issue 8, Page 4942-4950, June 2026.
Abstract BACKGROUND Sucuk is a traditional Turkish dry fermented sausage, the quality and safety of which depend on physicochemical, microbiological, and biochemical changes during fermentation and ripening. Organic acids, their salts, and antioxidants such as ascorbic acid (AA) are widely used in fermented meat products; however, information about ...
Gülsüme Bıçakcı, Ömer Eren
wiley   +1 more source

Preparation of Cod Gelatin Antifreeze Peptides and Its Application of Frozen-Thawed Surimi

Shipin gongye ke-ji
To optimize the preparation method of highly active cod gelatin antifreeze peptides (DcAFPs) and clarify its cryoprotective effects on surimi, this study added cod gelatin peptides to surimi.
Jin ZHANG, Tao YUAN, Xiaomei SHA, Yuelun XU, Yating KUANG, Zizi HU   +5 more
doaj   +1 more source