Results 151 to 160 of about 36,609 (227)

Mitochondrial respiration and hydrogen peroxide production rate in right atrial tissues from obese diabetic patients

open access: yesExperimental Physiology, Volume 111, Issue 4, Page 1643-1651, 1 April 2026.
Abstract Type 2 diabetes (T2D) is a global epidemic, with heart failure being the leading cause of premature death. Mitochondrial dysfunction, characterized by impaired energy metabolism, weakened energy transport system and increased oxidative stress, has been proposed as a key contributor to the impairment of contractile function in T2D hearts ...
Toan Pham   +4 more
wiley   +1 more source

Skeletal muscle myosin heavy chain fragmentation following exercise may be linked to post‐exercise inflammation and remodelling

open access: yesExperimental Physiology, Volume 111, Issue 4, Page 2123-2134, 1 April 2026.
Abstract The purpose of this exploratory investigation was to determine if acute post‐exercise skeletal muscle myosin heavy chain fragmentation (MyHCfrag) coincides with alterations in molecular chaperones and proteolytic enzymes, select markers of mammalian target of rapamycin complex 1 (mTORC1) signalling, and/or specific gene expression signatures ...
Dakota R. Tiede   +10 more
wiley   +1 more source

Translational studies of chronic supplementation with a mitochondria‐targeted antioxidant to improve physical function with ageing

open access: yesThe Journal of Physiology, Volume 604, Issue 7, Page 2898-2922, 1 April 2026.
Abstract figure legend Chronic oral supplementation with the mitochondria‐targeted antioxidant MitoQ (4 weeks; 250 µm) mitigates age‐related physical dysfunction in old mice, which is associated with reductions in skeletal muscle mitochondria‐specific superoxide and markers of mitochondrial reactive oxygen species (mitoROS)‐related oxidative stress and
Kevin O. Murray   +11 more
wiley   +1 more source

Cell‐cycle regulation of sarcomere integrity—Role for Actn2 phosphorylation

open access: yesPhysiological Reports, Volume 14, Issue 7, April 2026.
Abstract Sarcomeres are the fundamental contractile units of muscle. Despite their importance, sarcomere assembly remains poorly understood. We focused on Actn2, a protein which stabilizes the sarcomere by linking proteins to the Z‐disk. During C2C12 differentiation into myoblasts, Actn2 protein levels remained constant.
S. S. Baksh   +5 more
wiley   +1 more source

Oral amino acid tracer delivery detects feeding and exercise changes in myofibrillar protein synthesis rates in male adults. [PDF]

open access: yesPhysiol Rep
Mazzulla M   +7 more
europepmc   +1 more source

Integrative bioinformatic analysis identifies an extracellular matrix gene signature linked to muscle adaptation to endurance and resistance training

open access: yesPhysiological Reports, Volume 14, Issue 8, April 2026.
Abstract Skeletal muscle exhibits a remarkable adaptive capacity; endurance training enhances mitochondrial capacity, whereas resistance training improves mechanical strength. Despite these differences, both training impose repeated contractile and remodeling demands on skeletal muscle, suggesting a conserved transcriptional response that may underpin ...
Muhammad Isman Sandira   +5 more
wiley   +1 more source

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