Results 141 to 150 of about 1,662 (193)
Parthenolide attenuates skeletal muscle atrophy through coordinated regulation of protein homeostasis and inflammatory signaling. It counteracts TNF‐α‐mediated inhibition of AKT signaling, thereby restoring AKT–mTOR activation to promote protein synthesis and suppress protein degradation through inhibition of the FoxO transcription factors, which ...
Yu Bai +12 more
wiley +1 more source
Skeletal muscle in individuals with cerebral palsy (CP) may undergo accelerated aging through mechanisms shared with age‐related sarcopenia. Representative overlapping molecular and cellular features include, for example, neuromuscular alterations, impaired satellite cell function and niche composition, chronic inflammation, metabolic deficits, reduced
Oscar Horwath +5 more
wiley +1 more source
Abstract BACKGROUND Gynura procumbens is a medicinal plant widely recognized for its antioxidant and anti‐inflammatory properties. Despite its traditional use in Southeast Asia, its potential role in promoting muscle health has not been thoroughly investigated.
Taemin Jeong +5 more
wiley +1 more source
Geometrically Tunable Scaffold‐Free Muscle Bioconstructs for Treating Volumetric Muscle Loss
Volumetric muscle loss is associated with traumatic muscle resulting in permanent functional impairment. Mold‐based, scaffold‐free, high‐density muscle tissue bioconstructs are developed in customizable geometric shapes and sizes. The transplanted rectangular solid‐shaped muscle bioconstructs improved muscle force recovery and tissue regeneration in ...
Bugra Ayan +8 more
wiley +1 more source
Due to its multifunctionality, replicating the fibrillar and supramolecular architecture of Collagen I is gaining increasing priority in regenerative medicine. Using rotational Melt Electrofibrillation, we present a powerful method to accurately mimic the ultrastructure of Collagen with polycaprolactone, enabling the one‐step fabrication of three ...
Zan Lamberger +11 more
wiley +1 more source
Bioprinted Excitable Tissues with Multistimulation Systems for Promoting Function and Maturation
This review provides an overview of stimulation strategies used to enhance the functional maturation of bioprinted excitable tissues. It addresses key limitations in physiological performance of bioprinted excitable tissues, outlines major stimulation modalities—including electrical, mechanical, optical, magnetic, ultrasound, and hybrid—and examines ...
Uijung Yong, Jinseon Park, Jinah Jang
wiley +1 more source
ABSTRACT Anti‐synthetase syndrome (ASS) is a rare autoimmune disorder of idiopathic inflammatory myopathy spectrum, characterized by the presence of aminoacyl‐tRNA synthetase antibodies, most commonly anti‐Jo‐1. Clinically presents with interstitial lung disease (ILD), myositis, and arthritis, and may be confused with other autoimmune conditions such ...
Ali Gohar +7 more
wiley +1 more source
ABSTRACT Background PRRX1‐rearranged mesenchymal neoplasms are rare soft tissue tumors with a predilection for the superficial subcutaneous tissue. The PRRX1::KMT2D fusion variant is exceptionally rare, with only three previously reported cases, all of which were located in the intermuscular regions.
Weixiang Zhong, Yu Deng, Ke Sun
wiley +1 more source
PIEZO1 Channels Modulate the Small Extracellular Vesicle Release in C2C12 Cells
ABSTRACT PIEZO1 are mechanically‐activated ion channels expressed in many cell types. Their pharmacological activation by the selective agonist Yoda1 has been reported to favor skeletal muscle regeneration by controlling the fate of myogenic precursors cells, but the underlying mechanisms remain largely unknown.
Bernareggi Annalisa +11 more
wiley +1 more source
Workflow of the work. (1) Human muscle biopsies were collected, and the human muscle precursor cells (hMPC) were isolated, followed by co‐culture with human monocytes (THP‐1). In parallel, human muscles were decellularised to obtain an extracellular matrix (ECM) free of cells. ECM were recellularised by injecting hMPC and THP1 into the matrix.
Agner Henrique Dorigo Hochuli +20 more
wiley +1 more source

