Results 11 to 20 of about 7,261 (223)
Impact of Sustained Exogenous Irisin Myokine Administration on Muscle and Myocyte Integrity in Sprague Dawley Rats [PDF]
Metabolites, 2022 Irisin is an exercise-induced myokine implicated as a fundamental mediator of physical activity benefits. The aim of the present study was to investigate the role of the chronic administration model of irisin on the physiological and molecular status of ...
Foad Alzoughool +6 more
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Myokines: Do they really exist?
Journal of Physical Fitness and Sports Medicine, 2012 Skeletal muscle has only recently been considered a secretory organ. Muscle-derived proteins are now termed myokines. Until date, about 20 proteins known as cytokines, growth factors, and adipokines have been reported as myokines.
Yasuko Manabe +2 more
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Myokines in Acromegaly: An Altered Irisin Profile [PDF]
Frontiers in Endocrinology, 2021 IntroductionThe muscle is an endocrine organ controlling metabolic homeostasis. Irisin and myostatin are key myokines mediating this process. Acromegaly is a chronic disease with a wide spectrum of complications, including metabolic disturbances.PurposeTo examine the influence of acromegaly on irisin and myostatin secretion and their contribution to ...
Łukasz Mizera +7 more
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Physical Exercise-Induced Myokines in Neurodegenerative Diseases [PDF]
International Journal of Molecular Sciences, 2021 Neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are disorders characterized by progressive degeneration of the nervous system. Currently, there is no disease-modifying treatments for most NDs.
Banseok Lee +4 more
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Muscle in Endocrinology: From Skeletal Muscle Hormone Regulation to Myokine Secretion and Its Implications in Endocrine-Metabolic Diseases. [PDF]
J Clin MedIglesias P.
europepmc +3 more sources
FGF21 is an Akt‐regulated myokine [PDF]
FEBS Letters, 2008 Fibroblast growth factor‐21 (FGF21) functions as a metabolic regulator. The FGF21 transcript is reported to be abundantly expressed in liver, but little is known about the regulation of FGF21 expression in other tissues. In this study, we show that levels of FGF21 protein expression were similar in skeletal muscle and liver from fasted mice.
Izumiya, Yasuhiro +5 more
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Extracellular Vesicles: Delivery Vehicles of Myokines [PDF]
Frontiers in Physiology, 2019 Movement and regular physical activity are two important factors that help the human body prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart diseases, hypertension, sarcopenia, cachexia and cancer. During exercise, several tissues release molecules into the blood stream, and are able to mediate beneficial ...
Eleonora Trovato +4 more
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Connecting Myokines and Metabolism
Endocrinology and Metabolism, 2015 Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs.
Rexford S. Ahima, Hyeong-Kyu Park
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Muscle–Organ Crosstalk: The Emerging Roles of Myokines [PDF]
Endocrine Reviews, 2020 Abstract Physical activity decreases the risk of a network of diseases, and exercise may be prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia, cardiovascular diseases, and cancer. During the past couple of decades, it has been apparent that skeletal muscle works as an endocrine organ, which can ...
Mai Charlotte Krogh Severinsen +1 more
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Irisin Serum Levels and Skeletal Muscle Assessment in a Cohort of Charcot-Marie-Tooth Patients
Frontiers in Endocrinology, 2022 BackgroundCharcot-Marie-Tooth (CMT) indicates a group of inherited polyneuropathies whose clinical phenotypes primarily include progressive distal weakness and muscle atrophy.
Graziana Colaianni +13 more
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