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Muscles and their myokines [PDF]
Journal of Experimental Biology, 2011 SummaryIn the past, the role of physical activity as a life-style modulating factor has been considered as that of a tool to balance energy intake. Although it is important to avoid obesity, physical inactivity should be discussed in a much broader context.
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Extracellular Vesicles: Delivery Vehicles of Myokines [PDF]
Frontiers in Physiology, 2019 Movement and regular physical activity are two important factors that help the human body prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart diseases, hypertension, sarcopenia, cachexia and cancer. During exercise, several tissues release molecules into the blood stream, and are able to mediate beneficial ...
Eleonora Trovato +4 more
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Effects of myokines on bone [PDF]
BoneKEy Reports, 2016 The links between muscle and bone have been recently examined because of the increasing number of patients with osteoporosis and sarcopenia. Myokines are skeletal muscle-derived humoral cytokines and growth factors, which exert physiological and pathological functions in various distant organs, including the regulation of glucose, energy and bone ...
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Physical Exercise-Induced Myokines in Neurodegenerative Diseases [PDF]
International Journal of Molecular Sciences, 2021 Neurodegenerative diseases (NDs), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are disorders characterized by progressive degeneration of the nervous system. Currently, there is no disease-modifying treatments for most NDs.
Banseok Lee +4 more
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Muscle–Organ Crosstalk: The Emerging Roles of Myokines [PDF]
Endocrine Reviews, 2020 Abstract Physical activity decreases the risk of a network of diseases, and exercise may be prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia, cardiovascular diseases, and cancer. During the past couple of decades, it has been apparent that skeletal muscle works as an endocrine organ, which can ...
Mai Charlotte Krogh Severinsen +1 more
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Adipocyte, 2020 Regular exercise is the first line of therapy for treating obesity-mediated metabolic disorders, including insulin resistance. It has been reported that developmental endothelial locus-1 (DEL-1) enhances macrophage efferocytosis, resulting in ...
Chang Hyuk Kwon +5 more
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Obesity, Osteoarthritis, and Myokines: Balancing Weight Management Strategies, Myokine Regulation, and Muscle Health. [PDF]
NutrientsObesity and osteoarthritis (OA) are increasingly prevalent conditions that are intricately linked, with each exacerbating the other’s pathogenesis and worsening patient outcomes. This review explores the dual impact of obesity on OA, highlighting the role of excessive weight in aggravating joint degeneration and the limitations OA imposes on physical ...
Timofte DV +3 more
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Iron Metabolism of the Skeletal Muscle and Neurodegeneration
Frontiers in Neuroscience, 2019 Recent studies clearly indicate that the endocrine function of the skeletal muscle is essential for a long and healthy life. Regular exercise, which has been shown to stimulate the release of myokines, lowers the risk of many diseases, including ...
Malgorzata Halon-Golabek +3 more
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Frontiers in Endocrinology, 2018 BackgroundMyokines are a group of protein mediators produced by skeletal muscle under stress or physical exertion. Even though their discovery and effects in cell culture and animal models of disease have elicited great enthusiasm, very little is known ...
Freddy J. K. Toloza +10 more
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Myokines in metabolic homeostasis and diabetes [PDF]
Diabetologia, 2019 Physical activity exerts multiple beneficial effects and the myokine concept provides a framework for understanding the molecular pathways that integrate contracting muscle in the complex network of organ communication. This network includes multiple distinct and distal organs; however, the autocrine and paracrine effects of myokines within skeletal ...
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