Results 41 to 50 of about 7,261 (223)

Exercise training mode effects on myokine expression in healthy adults: A systematic review with meta-analysis

Journal of Sport and Health Science
Background: The benefits of exercise are well known; however, many of the underlying molecular mechanisms are not fully understood. Skeletal muscle secretes myokines, which mediate muscle–organ crosstalk.
Francesco Bettariga, Dennis R. Taaffe, Daniel A. Galvão, Pedro Lopez, Chris Bishop, Anna Maria Markarian, Valentina Natalucci, Jin-Soo Kim, Robert U. Newton   +8 more
doaj   +1 more source

Irisin levels are not affected by physical activity in patients with anorexia nervosa

Frontiers in Endocrinology, 2014
Irisin was recently identified as muscle-derived hormone that increases energy expenditure. Studies in normal weight and obese subjects reported an increased irisin expression following physical activity, although inconsistent results were observed ...
Tobias eHofmann, Ulf eElbelt, Ulf eElbelt, Anne eAhnis, Peter eKobelt, Matthias eRose, Andreas eStengel   +6 more
doaj   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Aberrant Myokine Signaling in Congenital Myotonic Dystrophy [PDF]

Cell Reports, 2017
Myotonic dystrophy types 1 (DM1) and 2 (DM2) are dominantly inherited neuromuscular disorders caused by a toxic gain of function of expanded CUG and CCUG repeats, respectively. Although both disorders are clinically similar, congenital myotonic dystrophy (CDM), a severe DM form, is found only in DM1. CDM is also characterized by muscle fiber immaturity
Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan ( host institution ), Nakamori, Masayuki ( author ), Hamanaka, Kohei ( author ), Thomas, James D. ( UF author ), Wang, Eric T. ( UF author ), Hayashi, Yukiko K. ( author ), Takahashi, Masanori P. ( author ), Swanson, Maurice S. ( UF author ), Nishino, Ichizo ( author ), Mochizuki, Hideki ( author )   +9 more
openaire   +4 more sources

Myokines: Novel therapeutic targets for diabetic nephropathy

Frontiers in Endocrinology, 2022
With the increasing incidence of diabetic nephropathy (DN), there is an urgent need to find effective DN preventive and therapeutic modalities. It is widely believed that effective exercise is good for health. However, the beneficial role of exercise in kidney disease, especially in DN, and the underlying molecular mechanisms have rarely been reported.
Ming Yang, Ming Yang, Shilu Luo, Jinfei Yang, Wei Chen, Liyu He, Di Liu, Li Zhao, Xi Wang, Xi Wang   +9 more
openaire   +3 more sources

Advances in the research on myokine-driven regulation of bone metabolism

Heliyon
The traditional view posits that bones and muscles interact primarily through mechanical coupling. However, recent studies have revealed that myokines, proteins secreted by skeletal muscle cells, play a crucial role in the regulation of bone metabolism ...
MingHong Shao, QiYang Wang, QiuNan Lv, YuQiong Zhang, GuoXi Gao, Sheng Lu   +5 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

The myokine irisin increases cortical bone mass [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Although exercise is a well known and potent stimulus for new bone formation, and weightlessness or muscle loss characteristically cause bone loss, it has remained unclear how muscle talks to bone, despite their close proximity.
COLAIANNI, GRAZIANA, CUSCITO, CONCETTA, MONGELLI, TERESA, Pignataro, Paolo, BUCCOLIERO, CINZIA, Liu, Peng, Lu, Ping, Sartini, Loris, DI COMITE, Mariasevera, MORI, GIORGIO, DI BENEDETTO, ADRIANA, BRUNETTI, GIACOMINA, Yuen, Tony, Sun, Li, Reseland, Janne E, COLUCCI, Silvia Concetta, New, Maria I, Zaidi, Mone, Cinti, Saverio, GRANO, Maria   +19 more
openaire   +3 more sources

Physical Exercise Inhibits Inflammation and Microglial Activation

Cells, 2019
Accumulating evidence indicates that exercise can enhance brain function and attenuate neurodegeneration. Besides improving neuroplasticity by altering the synaptic structure and function in various brain regions, exercise also modulates multiple systems
Onanong Mee-inta, Zi-Wei Zhao, Yu-Min Kuo   +2 more
doaj   +1 more source

All-trans Retinoic Acid and Beta-Carotene Increase Sclerostin Production in C2C12 Myotubes

Biomedicines, 2023
Sclerostin is a protein secreted by osteocytes whose encoding gene SOST is regulated by mechanical stimuli, cytokines, and all-trans retinoic acid (ATRA) and mediates antianabolic effects on bone formation as an inhibitor of the canonical Wnt/β-catenin ...
Franz Ewendt, Anne Lehmann, Maximilian F. Wodak, Gabriele I. Stangl   +3 more
doaj   +1 more source