Results 61 to 70 of about 7,261 (223)
Revista de la Sociedad Argentina de Diabetes, 2022 Skeletal muscle (SM) is not only a locomotor unit responsible for the propulsion and regulation of energy and metabolic processes. Now it is also recognized as an organ capable of producing molecules with vital functions: the so-called myokines1. Over the past two decades, it has become apparent that the ME functions as an endocrine organ in response ...
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Adipokines, Myokines and Cardiovascular Disease
Circulation Journal, 2009 It is recognized that obesity contributes to cardiovascular and metabolic disorders through alterations in the levels of adipocyte-derived cytokines (adipokines). Adiponectin is an adipokine that is downregulated in obese individuals. It has beneficial actions on the cardiovascular system by directly acting on the heart and blood vessels, and acute ...
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Experimental Physiology, EarlyView.Abstract A mouse model of HIV‐associated atherosclerosis (Tg26+/−ApoE−/−) exhibited increased plaque area compared with the ApoE−/− mouse, linked to elevated indoleamine 2,3‐dioxygenase (IDO) activity. IDO catalyses the conversion of tryptophan (TRP) into kynurenine (KYN), measured by the KYN‐to‐TRP ratio.
Marcus V. S. Rangel +5 more
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Skeletal Muscle and Bone – Emerging Targets of Fibroblast Growth Factor-21
Frontiers in Physiology, 2021 Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family, which functions as a powerful endocrine and paracrine regulator of glucose and lipid metabolism.
Hui Sun +4 more
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Experimental Physiology, EarlyView.Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė +10 more
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Multiple Roles in Neuroprotection for the Exercise Derived Myokine Irisin
Frontiers in Aging Neuroscience, 2021 Exercise has multiple beneficial effects on health including decreasing the risk of neurodegenerative diseases. Such effects are thought to be mediated (at least in part) by myokines, a collection of cytokines and other small proteins released from ...
Mohammad Jodeiri Farshbaf +2 more
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Experimental Physiology, EarlyView.Abstract Hepatic ischaemia–reperfusion (IR) injury is a serious clinical issue, especially in patients with type 2 diabetes mellitus (T2DM). As mitochondria play a critical role in the regulation of IR‐induced liver damage, mitochondria‐targeted treatment is of the utmost significance for improving outcomes.
Jie Lin +4 more
wiley +1 more source
Myokines: Crosstalk and Consequences on Liver Physiopathology
Nutrients, 2023 Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease mainly characterized by the hepatic accumulation of lipid inducing a deregulation of β-oxidation. Its advanced form is non-alcoholic steatohepatitis (NASH), which, in addition to lipid accumulation, induces hepatocellular damage, oxidative stress and fibrosis that can progress to ...
Aurore Dumond Bourie +3 more
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Biomechanical Stimulation of Muscles Influences Bone Phenotype by Modulating Myokine Secretion [PDF]
, 2022 Harshini Suresh Kumar +4 more
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Myokine Circulating Levels in Postmenopausal Women with Overweight or Obesity: Effects of Resistance Training and/or DHA-Rich n-3 PUFA Supplementation [PDF]
NutrientsMartínez-Gayo A +5 more
europepmc +3 more sources