Mammalian Myosin-18A, a Highly Divergent Myosin [PDF]
Journal of Biological Chemistry, 2013 The Mus musculus myosin-18A gene is expressed as two alternatively spliced isoforms, α and β, with reported roles in Golgi localization, in maintenance of cytoskeleton, and as receptors for immunological surfactant proteins. Both myosin-18A isoforms feature a myosin motor domain, a single predicted IQ motif, and a long coiled-coil reminiscent of myosin-
Stephanie, Guzik-Lendrum +7 more
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The ancient sarcomeric myosins found in specialized muscles
Skeletal Muscle, 2019 Striated muscles express an array of sarcomeric myosin motors that are tuned to accomplish specific tasks. Each myosin isoform found in muscle fibers confers unique contractile properties to the fiber in order to meet the demands of the muscle.
Lindsey A. Lee +3 more
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Myosin-Powered Membrane Compartment Drives Cytoplasmic Streaming, Cell Expansion and Plant Development. [PDF]
PLoS ONE, 2015 Using genetic approaches, particle image velocimetry and an inert tracer of cytoplasmic streaming, we have made a mechanistic connection between the motor proteins (myosins XI), cargo transported by these motors (distinct endomembrane compartment defined
Valera V Peremyslov +3 more
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Two essential light chains regulate the MyoA lever arm to promote Toxoplasma gliding motility [PDF]
, 2015 Key to the virulence of apicomplexan parasites is their ability to move through tissue and to invade and egress from host cells. Apicomplexan motility requires the activity of the glideosome, a multicomponent molecular motor composed of a type XIV myosin,
Alonso, Hernan +8 more
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Percolation with trapping mechanism drives active gels to the critically connected state
, 2015 Cell motility and tissue morphogenesis depend crucially on the dynamic remodelling of actomyosin networks. An actomyosin network consists of an actin polymer network connected by crosslinker proteins and motor protein myosins that generate internal ...
Lee, Chiu Fan, Pruessner, Gunnar
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Control of lipid organization and actin assembly during clathrin-mediated endocytosis by the cytoplasmic tail of the rhomboid protein Rbd2. [PDF]
, 2015 Clathrin-mediated endocytosis (CME) is facilitated by a precisely regulated burst of actin assembly. PtdIns(4,5)P2 is an important signaling lipid with conserved roles in CME and actin assembly regulation. Rhomboid family multipass transmembrane proteins
Cortesio, Christa L +2 more
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Distinct functional interactions between actin isoforms and nonsarcomeric myosins. [PDF]
PLoS ONE, 2013 Despite their near sequence identity, actin isoforms cannot completely replace each other in vivo and show marked differences in their tissue-specific and subcellular localization.
Mirco Müller +7 more
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Does the Actin Network Architecture Leverage Myosin-I Functions?
Biology, 2022 The actin cytoskeleton plays crucial roles in cell morphogenesis and functions. The main partners of cortical actin are molecular motors of the myosin superfamily.
Julien Pernier, Kristine Schauer
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The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi [PDF]
, 2016 Acknowledgements TG and CF are funded by FEDER funds through the Operational Programme Competitiveness Factors – COMPETE and national funds by FCT – Foundation for Science and Technology under the strategic project UID/NEU/04539/2013. C.F. is a recipient
Fernandes, Chantal +2 more
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Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes
Brain SciencesThe blood–brain barrier (BBB) comprises distinct cell types, including endothelial cells, pericytes, and astrocytes, and is essential for central nervous system (CNS) homeostasis by selectively regulating molecular transport and maintaining integrity. In
Ana Filipa Sobral +4 more
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