Results 41 to 50 of about 2,314 (212)

Autocatalytic Acylation of Phospholipase-like Myotoxins

Biochemistry, 1995
Several snake venoms contain a phospholipase A2 in which position 49 in the active site is occupied by a lysine or a serine instead of the aspartate residue normally found. Although these proteins do not bind Ca2+ and are devoid of catalytic activity, they are still highly specific myotoxins and have recently been shown to induce membrane leakage by a ...
PEDERSEN, JENS ZACHO, Lomonte, B, MASSOUD, RENATO, Gubensek, F, Gutiérrez, J, RUFINI, STEFANO   +5 more
openaire   +5 more sources

The sex‐specific prognostic utility of sarcopenia in cirrhosis

Journal of Cachexia, Sarcopenia and Muscle, Volume 13, Issue 6, Page 2608-2615, December 2022., 2022
Abstract Sarcopenia is an increasingly recognized complication of cirrhosis that is associated with morbidity and mortality. Differences in the prevalence and prognosis of sarcopenia between men and women have been reported in other patient groups, but there is insufficient understanding of how sex impacts the prognostic value of sarcopenia in ...
Ryan Lowe, Penelope Hey, Marie Sinclair
wiley   +1 more source

PhTX-II a Basic Myotoxic Phospholipase A2 from Porthidium hyoprora Snake Venom, Pharmacological Characterization and Amino Acid Sequence by Mass Spectrometry

Toxins, 2014
A monomeric basic PLA2 (PhTX-II) of 14149.08 Da molecular weight was purified to homogeneity from Porthidium hyoprora venom. Amino acid sequence by in tandem mass spectrometry revealed that PhTX-II belongs to Asp49 PLA2 enzyme class and displays ...
Salomón Huancahuire-Vega, Luis Alberto Ponce-Soto, Sergio Marangoni   +2 more
doaj   +1 more source

Biological characterization of a myotoxin phosphoplipase A2 homologue purified from the venom of the snake Bothrops moojeni

Journal of Venomous Animals and Toxins including Tropical Diseases, 2011
A myotoxin phospholipase A2 homologue, BmooMtx, was isolated from the venom of Bothrops moojeni by a combination of ion-exchange chromatography on DEAE-Sephacel column and gel filtration on Sephadex G-75. SDS-PAGE showed the enzyme to be a monomer with a
MR Queiroz, CC Mamede, KC Fonseca, LCMN Canabrava, LV França, MC Silva, L Stanziola, ME Beletti, HAN Canabrava, F Oliveira   +9 more
doaj   +1 more source

The Effect of Anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Human Autoantibodies on Muscle Regeneration in Mice. [PDF]

Muscle Nerve
ABSTRACT Introduction/Aims Anti‐3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) autoantibodies (aAbs) are pathogenic in immune‐mediated necrotizing myopathy (IMNM), partly through complement activation. C5 inhibition did not restore muscle strength in mice or patients with overt IMNM, suggesting additional pathogenic mechanisms.
Julien S, Tomasevic H, Jaworski T, Zoubairi R, Martinet J, Drouot L, Boyer O.   +6 more
europepmc   +2 more sources

p21‐activated kinase 4 phosphorylates peroxisome proliferator‐activated receptor Υ and suppresses skeletal muscle regeneration

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Skeletal muscle regeneration is an adaptive response to injury that is crucial to the maintenance of muscle mass and function. A p21‐activated kinase 4 (PAK4) serine/threonine kinase is critical to the regulation of cytoskeletal changes, cell ...
Yuancheng Mao, Chang Yeob Han, Lihua Hao, In Hyuk Bang, Eun Ju Bae, Byung‐Hyun Park   +5 more
doaj   +1 more source

Mechanism of inhibition of Ca2+-ATPase by myotoxin a [PDF]

Biochemical Journal, 1995
The peptide DCRQKWKCCKKGSG [myotoxin-(29-42)], corresponding to residues 29-42 of myotoxin a, inhibits the activity of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum, with a Kd value of 19.4 microM at pH 7.5, in 100 mM KCl. The peptide YKQCHKKGGHCFPKEK, corresponding to residues 1-16 of myotoxin a, is a less potent inhibitor. Inhibition by
K J, Baker, J M, East, A G, Lee
openaire   +2 more sources

Alpha-type phospholipase A2 inhibitors from snake blood

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
It is of popular and scientific knowledge that toxins from snake venom (among them the PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and proteins purified from animal blood.
Norival A. Santos-Filho, Claudia T. Santos   +1 more
doaj   +1 more source

Endogenous phospholipase A2 inhibitors in snakes: a brief overview

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation.
Patrícia Cota Campos, Lutiana Amaral de Melo, Gabriel Latorre Fortes Dias, Consuelo Latorre Fortes-Dias   +3 more
doaj   +1 more source

Recent Trends in Injury Models to Study Skeletal Muscle Regeneration and Repair

Bioengineering, 2020
Skeletal muscle injuries that occur from traumatic incidents, such as those caused by car accidents or surgical resections, or from injuries sustained on the battlefield, result in the loss of functionality of the injured muscle.
Sydnee T. Sicherer, Rashmi S. Venkatarama, Jonathan M. Grasman   +2 more
doaj   +1 more source