Results 141 to 150 of about 4,502 (185)

“In vivo biosynthesis of N,N-dimethyltryptamine, 5-MeO-N,N-dimethyltryptamine, and bufotenine in E. coli”

Metabolic Engineering, 2023
N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and 5-hydroxy-N,N-dimethyltryptamine (bufotenine) are psychedelic tryptamines found naturally in both plants and animals and have shown clinical potential to help treat mental disorders, such as anxiety and depression.
Lucas M. Friedberg, Abhishek K. Sen, Quynh Nguyen, Gabriel P. Tonucci, Elle B. Hellwarth, William J. Gibbons, J. Andrew Jones   +6 more
openaire   +2 more sources

N,N-Dimethyltryptamine–Induced Psychosis

Clinical Neuropharmacology, 2015
N,N-dimethyltryptamine (DMT) is a 5-hydroxytryptamine 2A and 1A receptor agonist that exhibits potent psychoactive properties in humans. Recreational use of this drug has increased precipitously and is likely to result in an increase in patients presenting with substance-induced psychoses. The present case provides an early example of substance-induced
Neil E, Paterson, W Connor, Darby, Preetpal S, Sandhu   +2 more
openaire   +2 more sources

Persistent Tinnitus after Inhaled N,N-dimethyltryptamine (DMT)

Journal of Psychoactive Drugs, 2020
This case report describes a 39-year-old male with remote history of polysubstance use disorder and depression who developed tinnitus after use of inhaled N,N-dimethyltryptamine (DMT). Although development of ear ringing was attributed to use on a single occasion, tinnitus occurred within the context of a larger self-experiment involving weekly ...
Heba Diab, Benjamin Malcolm
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In vivo metabolism of 5-methoxy-N, N-dimethyltryptamine and N,N-dimethyltryptamine in the rat

Biochemical Pharmacology, 1987
Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N ...
B R, Sitaram, L, Lockett, R, Talomsin, G L, Blackman, W R, McLeod   +4 more
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A new metabolic pathway for N,N-dimethyltryptamine

Biological Psychiatry, 1986
N,N-Dimethyltryptamine (DMT) undergoes a major structural alteration when added to whole human blood or its red blood cells in vitro. A new high-pressure liquid chromatography (HPLC) peak is present in extracts of these treated tissues. The compound responsible for this peak has been identified by ultraviolet spectrophotometry and by mass spectrometry ...
L M, Hryhorczuk, J M, Rainey, C E, Frohman, E A, Novak   +3 more
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N,N-Dimethyltryptamine: An Endogenous Hallucinogen

1981
Publisher Summary This chapter reviews the biosynthesis, metabolism, pharmacology, and properties of N,N-dimethyltryptamine (DMT), leading to a conclusion that DMT may be a neurotransmitter in the mammalian brain. The identification of DMT and other hallucinogens in man explains the experience of hallucinatory phenomena in general.
S A, Barker, J A, Monti, S T, Christian
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Biosynthesis and turnover of N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine in Phalaris tuberosa

Phytochemistry, 1972
Abstract The biosynthesis and turnover of N , N -dimethyltryptamine and 5-methoxy- N , N -dimethyltryptamine have been studied in the pasture grass Phalaris tuberosa by a combination of feeding and trapping experiments using radioisotopically labelled compounds. Their turnover has been demonstrated by feeding tryptophan and tryptamine.
Claire Baxter, M. Slaytor
openaire   +1 more source

Neuromodulatory mechanisms of N,N-dimethyltryptamine

Brain Network and Modulation, 2023
N,N-dimethyltryptamine (DMT) is the simplest psychedelic tryptamine and is produced naturally by many plant and animal species, including humans. While classical psychedelics, such as lysergic acid diethylamide, or psilocybin, are gaining interest because of their therapeutic potential, DMT has yet to be fully investigated ...
openaire   +1 more source

Studies on several 7-substituted N,N-dimethyltryptamines

Journal of Medicinal Chemistry, 1980
Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats. Both 7-Me- and 5-OMe-7-Me-DMT possess a higher pA2, and 5,7-(OMe)2-DMT a lower pA2, than that of DMT itself.
R A, Glennon, E, Schubert, J M, Jacyno, J A, Rosecrans   +3 more
openaire   +2 more sources

N,N-dimethyltryptamine like substance in rat brain

Life Sciences, 1973
Abstract Rat brain contains 8 μg/g of a tertiary amine, very probably N,N-dimethyltryptamine as shown by bidimensional thin layer and gas ohromatography. Pretreatment with Nialamide did not modify the concentration of this substance in the brain.
B, Heller, E, Fischer, H, Spats
openaire   +2 more sources