Efficacy of N, N-dimethyltryptamine (DMT) psychedelic therapy for substance misuse: A systematic review and meta-analysis. [PDF]
J PsychopharmacolBackground: Conventional psychological and pharmacological substance abuse treatments are limited to moderate effect sizes and fail to magnify outcomes when combined. Analog psychedelic agents N, N-dimethyltryptamine (DMT) and 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) show therapeutic potential for treatment-
Wallace LM +5 more
europepmc +4 more sources
Biosynthesis of N,N-dimethyltryptamine (DMT) in a melanoma cell line and its metabolization by peroxidases [PDF]
Biochemical Pharmacology, 2014 Tryptophan (TRP) is essential for many physiological processes, and its metabolism changes in some diseases such as infection and cancer. The most studied aspects of TRP metabolism are the kynurenine and serotonin pathways. A minor metabolic route, tryptamine and N,N-dimethyltryptamine (DMT) biosynthesis, has received far less attention, probably ...
Gomes, Melissa M. +9 more
openaire +3 more sources
Frontiers in Neuroscience, 2018 N,N-dimethyltryptamine (DMT) is a powerful serotonergic psychedelic whose exogenous administration elicits striking psychedelic effects in humans. Studies have identified DMT and analogous compounds (e.g., 5-hydroxy-DMT, 5-methoxy-DMT) alongside of an ...
Jon G. Dean
doaj +2 more sources
Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. [PDF]
PLoS ONE, 2014 The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation and cell survival, and mediates anti-inflammatory ...
Attila Szabo +3 more
doaj +2 more sources
Complexity and connectivity markers for N,N-dimethyltryptamine (DMT) [PDF]
N, N-Dimethyltryptamine (DMT) is a substance used in indigenous rituals. This psychedelic drug has attracted recent interest for its potential in psychotherapy, yet its effects on the brain remain unclear. The main objective of this project is to analyze through various biomarkers, how the brain functions in altered states of consciousness, such as ...
Araujo Rodríguez, Helena María
core +4 more sources
N,N-dimethyltryptamine (DMT) is neither formed nor retained in serotonin terminals in the rat brain
NeuropharmacologyMammalian brain may contain an endogenous pool of the psychedelic substance N,N-dimethyltryptamine (DMT), which may act as a co-transmitter with serotonin (5-HT). We tested the joint hypotheses. We tested the joint hypotheses that endogenous DMT would accumulate in rat brain after inhibiting monoamine oxidase with pargyline, whereas its acidic ...
Mikael Palner +4 more
openaire +4 more sources
Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT. [PDF]
Psychopharmacology (Berl), 2022 As with all drugs, the route, form, and/or dose of a substance administered or applied can play a defining role in its overall pharmacology and use as a therapeutic. This review will focus on these factors as they relate to the psychedelic N,N-dimethyltryptamine (DMT).
Barker SA.
europepmc +4 more sources
Correction to: Administration of N,N‑dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT. [PDF]
Psychopharmacology (Berl), 2022 Barker SA.
europepmc +3 more sources
Proliferative Effects of the Psychedelic N,N-Dimethyltryptamine (DMT) in Human Neural Stem Cells. [PDF]
ACS Chem NeurosciThe serotonergic psychedelic N,N-dimethyltryptamine (DMT) produces rapid antidepressant effects in preclinical and early clinical studies. Therapeutic benefits have been linked to sustained neural plasticity, including adult neurogenesis in rodents ...
Salerno JA +9 more
europepmc +2 more sources
Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain. [PDF]
Sci Rep, 2019 AbstractN,N-dimethyltryptamine (DMT), a psychedelic compound identified endogenously in mammals, is biosynthesized by aromatic-L-amino acid decarboxylase (AADC) and indolethylamine-N-methyltransferase (INMT). Whether DMT is biosynthesized in the mammalian brain is unknown.
Dean JG +7 more
europepmc +4 more sources