Results 41 to 50 of about 13,568,693 (193)

A mood disorder episode with an onset under chronic cannabis consumption and accompanied with psychotic features immediately after N, N-Dimethyltryptamine (DMT) use: a case report [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2011
, N-dimethyltryptamine (DMT) is a serotonin agonist hallucinogen, similar to lysergic acid diethylamide (LSD). Syntetic production of DMT as well as extraction from several plants of South American flora is possible.
Güliz Özgen, İlker Küçükparlak, Gökhan Umut, Ahmet Türkcan   +3 more
doaj  

A pilot study of cerebral metabolism and serotonin 5-HT2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine

Frontiers in Pharmacology, 2023
Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT2A receptors by N,N-dimethyltryptamine (DMT).
Klemens Egger, Klemens Egger, Klemens Egger, Frederik Gudmundsen, Frederik Gudmundsen, Naja Støckel Jessen, Naja Støckel Jessen, Naja Støckel Jessen, Christina Baun, Christina Baun, Sandra N. Poetzsch, Vladimir Shalgunov, Vladimir Shalgunov, Matthias M. Herth, Matthias M. Herth, Boris B. Quednow, Boris B. Quednow, Chantal Martin-Soelch, Dario Dornbierer, Milan Scheidegger, Milan Scheidegger, Paul Cumming, Paul Cumming, Mikael Palner, Mikael Palner, Mikael Palner   +25 more
doaj   +1 more source

In silico study of dimethyltryptamine analogues against 5-HT1B receptor: Molecular docking, dynamic simulations and ADMET prediction [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: The 5-HT1B receptor has a potential role in various psychiatric disorders such as depression, anxiety, and post-traumatic stress disorder.
Neyder Contreras, Antistio Alvíz-Amador, Isabella Manzur-Villalobos   +2 more
doaj   +1 more source

A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus

Frontiers in Molecular Neuroscience, 2018
The subgranular zone (SGZ) of dentate gyrus (DG) is one of the few regions in which neurogenesis is maintained throughout adulthood. It is believed that newborn neurons in this region encode temporal information about partially overlapping contextual ...
Rafael Vitor Lima da Cruz, Thiago C. Moulin, Lyvia Lintzmaier Petiz, Richardson N. Leão, Richardson N. Leão   +4 more
doaj   +1 more source

Psychedelics: A new era of treatment?

European Psychiatry, 2021
Introduction Psychedelics - including LSD (lysergic acid diethylamide), psilocybin, DMT (N, N-dimethyltryptamine), ayahuasca and mescaline - have an ancient history across various civilizations.
S. Torres
doaj   +1 more source

Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents. [PDF]

ACS Chem Neurosci, 2019
Drugs capable of ameliorating symptoms of depression and anxiety while also improving cognitive function and sociability are highly desirable. Anecdotal reports have suggested that serotonergic psychedelics administered in low doses on a chronic ...
Cameron LP, Benson CJ, DeFelice BC, Fiehn O, Olson DE.   +4 more
europepmc   +2 more sources

Updated View on the Relation of the Pineal Gland to Autism Spectrum Disorders

Frontiers in Endocrinology, 2019
Identification of the biological features of autism is essential for designing an efficient treatment and for prevention of the disorder. Though the subject of extensive research, the neurophysiological features of autism remain unclear.
Tal Shomrat, Nir Nesher
doaj   +1 more source

Baseline Power of Theta Oscillations Predicts Mystical-Type Experiences Induced by DMT in a Natural Setting

Frontiers in Psychiatry, 2021
N,N-Dimethyltryptamine (DMT) is a classic psychedelic capable of inducing short-lasting but profound changes in consciousness. As with other psychedelics, the experience induced by DMT strongly depends upon contextual factors, yet the neurobiological ...
Enzo Tagliazucchi, Enzo Tagliazucchi, Federico Zamberlan, Federico Cavanna, Federico Cavanna, Laura de la Fuente, Celeste Romero, Yonatan Sanz Perl, Yonatan Sanz Perl, Carla Pallavicini, Carla Pallavicini   +10 more
doaj   +1 more source

Conformational, spectroscopic and nonlinear optical properties of biologically active N,N-dimethyltryptamine molecule: A theoretical study

, 2014
The effective psychoactive properties of N,N-dimethyltryptamine (DMT) known as the near-death molecule have encouraged the imagination of many research disciplines for several decades. Although there is no theoretical study, a number of paper composed by
Atalay Y., Tamer Ö, Avcı, Davut, Atalay, Yusuf, N, Öner, Öner N, Tamer, Ömer, Avcı D   +7 more
core   +1 more source

Quantum chemical study of the hydrolysis of oxidized endogenous psychedelic N,N-dimethyltryptamine [PDF]

, 2022
The metabolism of biogenic N,N-dimethyltryptamine (DMT) starts with its enzymatic oxidation to indole-3-N,N-dimethylethaniminium cation (imDMT(+)) by monoamine oxidase (MAO).
Kubicsko, Karoly, Kovacs, Richard D., Farkas, Odon   +2 more
core   +1 more source