Results 31 to 40 of about 13,568,693 (193)

Reactivations after 5-methoxy-N,N-dimethyltryptamine use in naturalistic settings: An initial exploratory analysis of the phenomenon’s predictors and its emotional valence

Frontiers in Psychiatry, 2022
BackgroundThe psychedelic 5-MeO-DMT has shown clinical potential due to its short duration and ability to induce mystical experiences. However, a phenomenon known as “reactivations” (similar to “flashbacks”) is a poorly understood and frequently reported
Ana María Ortiz Bernal, Charles L. Raison, Rafael L. Lancelotta, Alan K. Davis, Alan K. Davis   +4 more
doaj   +1 more source

Synthesis and Biological Evaluation of 4‑Bromo-N,N-dimethyltryptamine (4-Br-DMT): A Synthetic Building Block for Future Analog Development [PDF]

ACS Omega
Elena Bray, Grant C. Glatfelter, Alexander D. Maitland, Nicholas R. Gonzalez, Donna Walther, Jeanine Yacoub, Michael H. Baumann, Jacqueline L. von Salm   +7 more
doaj   +2 more sources

Discovery and In Vitro Characterization of SPL028: Deuterated N,N‑Dimethyltryptamine

, 2023
The psychedelic N,N- dimethyltryptamine (DMT) is in clinical development for the treatment of major depressive disorder. However, when administered via intravenous infusion, its effects are short-lived due to rapid clearance.
Zelah Joel (16912794), Marie Layzell (16912785), Peter Rands, Carol Routledge, Carol Routledge (3023037), Ellen James (12499174), Meghan Good, Rick Cousins (5932172), Ellen James, Peter Rands (16912788), Rick Cousins, Tiffanie Benway (16912797), Zelah Joel, Meghan Good (16912791), Tiffanie Benway, Marie Layzell   +15 more
core   +2 more sources

DMT Models the Near-Death Experience

Frontiers in Psychology, 2018
Near-death experiences (NDEs) are complex subjective experiences, which have been previously associated with the psychedelic experience and more specifically with the experience induced by the potent serotonergic, N,N-Dimethyltryptamine (DMT).
Christopher Timmermann, Christopher Timmermann, Leor Roseman, Leor Roseman, Luke Williams, David Erritzoe, Charlotte Martial, Héléna Cassol, Steven Laureys, David Nutt, Robin Carhart-Harris   +10 more
doaj   +1 more source

On the markers for schizophrenia

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2021
Summary. The study of various markers indicating an imbalance in both the neurotransmitter and immune systems observed in patients with schizophrenia is currently of great scientific and practical interest.
A. N. Erichev, I. I. Bode, V. O. Polyakova, A. P. Kotsubinsky, B. G. Butoma   +4 more
doaj   +1 more source

Psychedelic Therapy: A Primer for Primary Care Clinicians – Part III. N,N-dimethyltryptamine (DMT) and Ayahuasca

, 2023
Background: N,N-dimethyltryptamine (DMT) is a naturally-occurring serotonergic psychedelic found in natural plants around the globe. As the main psychoactive component in ayahuasca, which also contains monoamine oxidase (MAO) inhibitors, DMT has been ...
Owen S. Muir, Chelsey Fasano, Kenneth Shinozuka, Bryce D. Beutler, Viviana D. Evans, Alejandro Arenas, Kirsten Cherian, Burton J. Tabaac   +7 more
core   +1 more source

DMT alters cortical travelling waves

eLife, 2020
Psychedelic drugs are potent modulators of conscious states and therefore powerful tools for investigating their neurobiology. N,N, Dimethyltryptamine (DMT) can rapidly induce an extremely immersive state of consciousness characterized by vivid and ...
Andrea Alamia, Christopher Timmermann, David J Nutt, Rufin VanRullen, Robin L Carhart-Harris   +4 more
doaj   +1 more source

Population pharmacokinetic/pharmacodynamic modeling of the psychedelic experience induced by N,N‐dimethyltryptamine – Implications for dose considerations

Clinical and Translational Science, 2022
N,N‐dimethyltryptamine (DMT) is a psychedelic compound that is believed to have potential as a therapeutic option in several psychiatric disorders. The number of clinical investigations with DMT is increasing.
Emma Eckernäs, Christopher Timmermann, Robin Carhart‐Harris, Daniel Röshammar, Michael Ashton   +4 more
doaj   +1 more source

Pharmacokinetics and pharmacodynamics of the psychedelic compound DMT [PDF]

, 2023
N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being investigated as a treatment option in depression. It is also being used as a research tool in research aiming to investigate the neurobiology of the human consciousness using ...
Eckernäs, Emma
core   +1 more source

Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer

Journal of Experimental & Clinical Cancer Research, 2021
Background Castration-resistant prostate cancer (CRPC) is associated with a very poor prognosis, and the treatment of which remains a serious clinical challenge.
Shangwei Zhong, Ji-Hak Jeong, Changhao Huang, Xueyan Chen, Shohreh Iravani Dickinson, Jasreman Dhillon, Li Yang, Jun-Li Luo   +7 more
doaj   +1 more source