Results 21 to 30 of about 13,568,693 (193)

Clinical Pharmacokinetics of N,N-Dimethyltryptamine (DMT): A Systematic Review and Post-hoc Analysis. [PDF]

Clin Pharmacokinet
N,N-Dimethyltryptamine (DMT) is currently being studied for its therapeutic potential in various psychiatric disorders. An understanding of its pharmacokinetics (PK) is essential to determine appropriate dose ranges in future clinical studies. We conducted a systematic literature review on the PK of DMT.Clinical studies that administered known amounts ...
van der Heijden KV, Otto ME, Schoones JW, van Esdonk MJ, Borghans LGJM, van Hasselt JGC, van Gerven JMA, Jacobs G.   +7 more
europepmc   +5 more sources

Continuous flow synthesis of <i>N</i>,<i>N</i>-dimethyltryptamine (DMT) analogues with therapeutic potential. [PDF]

RSC Med Chem
Herein, we describe the continuous flow synthesis and in-line extraction of N,N-dimethyltryptamine (DMT) and several of its analogues using a Fischer indole reaction, along with a larger gram scale synthesis (4.75 g) of the model compound. These products
Simoens A, Dejaegere A, Vandevelde M, Stevens CV.   +3 more
europepmc   +2 more sources

Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors. [PDF]

Cell Mol Life Sci
The potent hallucinogen N,N-dimethyltryptamine (DMT) has garnered significant interest in recent years due to its profound effects on consciousness and its therapeutic psychopotential.
Egger K, Aicher HD, Cumming P, Scheidegger M.   +3 more
europepmc   +3 more sources

Reconstituting a two-step pathway for <i>N</i>,<i>N</i>-dimethyltryptamine (DMT) biosynthesis in bacteria. [PDF]

Metab Eng Commun
Junges LH, Pontes FLD, Mota FJT, Passaglia Bruschi G, Bonaldi MPF, de Souza EM, Müller-Santos M.   +6 more
europepmc   +2 more sources

The pharmacological interaction of compounds in ayahuasca: a systematic review [PDF]

Brazilian Journal of Psychiatry, 2020
Ayahuasca is a South American psychoactive plant brew used as traditional medicine in spiritual and in cultural rituals. This is a review of the current understanding about the pharmacological mechanisms that may be interacting in ayahuasca.
Simon Ruffell, Nige Netzband, Catherine Bird, Allan H. Young, Mario F. Juruena   +4 more
doaj   +1 more source

Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact. [PDF]

Pharmaceuticals (Basel), 2020
Ayahuasca is a hallucinogenic botanical beverage originally used by indigenous Amazonian tribes in religious ceremonies and therapeutic practices. While ethnobotanical surveys still indicate its spiritual and medicinal uses, consumption of ayahuasca has ...
Brito-da-Costa AM, Dias-da-Silva D, Gomes NGM, Dinis-Oliveira RJ, Madureira-Carvalho Á.   +4 more
europepmc   +2 more sources

Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats

Scientific Reports, 2023
Indolethylamine N-methyltransferase (INMT) is a transmethylation enzyme that utilizes the methyl donor S-adenosyl-L-methionine to transfer methyl groups to amino groups of small molecule acceptor compounds.
Nicolas G. Glynos, Lily Carter, Soo Jung Lee, Youngsoo Kim, Robert T. Kennedy, George A. Mashour, Michael M. Wang, Jimo Borjigin   +7 more
doaj   +1 more source

A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers

Frontiers in Pharmacology, 2021
5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospective studies for other tryptamines have suggested beneficial effects on mental health outcomes.
Johannes Reckweg, Natasha L. Mason, Cees van Leeuwen, Stefan W. Toennes, Theis H. Terwey, Johannes G. Ramaekers   +5 more
doaj   +1 more source

Disintegration of Default Mode: Functional MRI Insights Into N,N-Dimethyltryptamine (DMT), Consciousness, and Subcortical Connectivity. [PDF]

Cureus
N,N-Dimethyltryptamine (DMT), a potent endogenous psychedelic, evokes rapid and immersive shifts in consciousness that challenge conventional neurocognitive models. Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG)-fMRI studies suggest that these altered states are not chaotic but patterned, marked by a disruption of the ...
Avakian A.
europepmc   +4 more sources

sj-docx-1-jop-10.1177_02698811221104054 – Supplemental material for Significance of mammalian N, N-dimethyltryptamine (DMT): A 60-year-old debate

, 2022
Supplemental material, sj-docx-1-jop-10.1177_02698811221104054 for Significance of mammalian N, N-dimethyltryptamine (DMT): A 60-year-old debate by Javier Hidalgo Jiménez and José Carlos Bouso in Journal of ...
Javier Hidalgo Jiménez (12876833), José Carlos Bouso (10680081)   +1 more
core   +1 more source