Results 41 to 50 of about 47,831 (279)
Treatment with aripiprazole and N ‐acetylcysteine affects anaerobic cysteine metabolism in the hippocampus and reverses schizophrenia‐like behavior in the neurodevelopmental rat model of schizophrenia [PDF]
, 2023 Magdalena Górny +4 more
openalex +1 more source
Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects
Advanced Healthcare Materials, EarlyView.Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt +7 more
wiley +1 more source
Melatonin and N- Acetylcysteine as Remedies for Tramadol-Induced Hepatotoxicity in Albino Rats [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: The therapeutic benefit derived from the clinical use of tramadol (TD) has been characterized by hepatotoxicity due to misuse and abuse. The implications of drug-induced hepatotoxicity include socio-economic burden which makes the search for ...
Elias Adikwu, Bonsome Bokolo
doaj +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Tailored Xenogeneic‐Free Polymer Surface Promotes Dynamic Migration of Intestinal Stem Cells
Advanced Materials, EarlyView.This study introduces a PoLymer‐coated Ultra‐stable Surface (PLUS), a nitrogen plasma‐treated poly(ethyleneglycoldimethacrylate), as a stable xenogeneic‐free platform for intestinal stem cell culture. PLUS enhances cell attachment, supports actin‐driven migration, and retains functionality after 3 years of storage. Promoting cytoskeletal reorganization,
Seonghyeon Park +13 more
wiley +1 more source
N-acetylcysteine in acute pancreatitis
World Journal of Gastrointestinal Pharmacology and Therapeutics, 2010 Premature trypsinogen activation and production of oxygen free radicals (OFR) are early pathogenic events which occur within acinar cells and trigger acute pancreatitis (AP). OFR exert their harmful effects on various cell components causing lipid peroxidation, disturbances in calcium homeostasis and DNA damage, which lead to increased cell injury and ...
Laura, Ramudo, Manuel A, Manso
openaire +2 more sources
Advanced Science, EarlyView.In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo +6 more
wiley +1 more source
Severe Chest Pain due to N-Acetylcysteine-Induced Esophagitis
Case Reports in Medicine, 2019 We report an unusual case of severe chest pain caused by N-acetylcysteine-induced esophagitis. An 81-year-old Chinese man with a history of interstitial lung disease was admitted to our hospital with intermittent arrhythmia that began 5 days ago.
Weihong Wang +4 more
doaj +1 more source
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure
Hepatic Medicine: Evidence and Research, 2020 Gebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Filmon Beyenne Demoz Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Gebrehiwot Gebremedhin Tafere P.O.
Tafere GG, Wondafrash DZ, Demoz FB
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