A Novel Variant in CMAH Is Associated with Blood Type AB in Ragdoll Cats. [PDF]
PLoS ONE, 2016 The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase is associated with the production of sialic acids on cat red blood cells. The cat has one major blood group with three serotypes; the most common blood type A being dominant to type B. A
Barbara Gandolfi +9 more
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Correlation of Serum N-Acetylneuraminic Acid with the Risk of Moyamoya Disease [PDF]
Brain Sciences, 2023 N-acetylneuraminic acid (Neu5Ac) is a functional metabolite and has been demonstrated to be a risk factor for cardiovascular diseases. It is not clear whether Neu5Ac is associated with a higher risk of cerebrovascular disorders, especially moyamoya ...
Chenglong Liu +15 more
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Recent advances on N-acetylneuraminic acid: Physiological roles, applications, and biosynthesis [PDF]
Synthetic and Systems Biotechnology, 2023 N-Acetylneuraminic acid (Neu5Ac), the most common type of Sia, generally acts as the terminal sugar in cell surface glycans, glycoconjugates, oligosaccharides, lipo-oligosaccharides, and polysaccharides, thus exerting numerous physiological functions ...
Mingli Zhao +4 more
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Multistep metabolic engineering of Pichia pastoris for biosynthesis of N‑acetylneuraminic acid [PDF]
Applied Microbiology and BiotechnologyFree or protein-conjugated N-Acetylneuraminic acid (Neu5Ac) is widely distributed in organisms and possesses diverse biological functions, and for example lactoferrin with Neu5Ac-mediated sialylation exhibits significantly enhanced functional activity ...
Xiaomin Zhao +7 more
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Many locks to one key: N-acetylneuraminic acid binding to proteins [PDF]
IUCrJSialic acids play crucial roles in cell surface glycans of both eukaryotic and prokaryotic organisms, mediating various biological processes, including cell–cell interactions, development, immune response, oncogenesis and host–pathogen interactions. This
KanagaVijayan Dhanabalan +3 more
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Molecular characterization of cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) associated with the erythrocyte antigens in dogs [PDF]
Canine Genetics and Epidemiology, 2019 Background N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5′-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene.
Yumiko Uno +3 more
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Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction [PDF]
Nature Communications, 2020 An imbalance between cell growth and bioproduction of engineered microbes often reduces production efficiency. Here, the authors report genetic code expansion-based cell growth and biosynthesis balance engineering to achieve high levels production of N ...
Rongzhen Tian +7 more
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Presence of N-acetylneuraminic acid in the lung during postnatal development [PDF]
European Journal of Histochemistry, 2020 Sialic acids, particularly N-acetylneuraminic acid (Neu5Ac), are present as terminal components of rich and complex oligosaccharide chains, which are termed glycans, and are exhibited on the cell surfaces, especially on epithelial cells.
Maria de Fátima Martins +3 more
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Characterization of a novel N-acetylneuraminic acid lyase favoring industrial N-acetylneuraminic acid synthesis. [PDF]
Sci Rep, 2015 AbstractN-Acetylneuraminic acid lyase (NAL, E.C. number 4.1.3.3) is a Class I aldolase that catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) from pyruvate and N-acetyl-D-mannosamine (ManNAc). Due to the high Neu5Ac cleavage activity in most isozyme forms, the enzyme catalyzes the rate-limiting step of two biocatalytic ...
Ji W +7 more
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Identification of an N-acetylneuraminic acid-presenting bacteria isolated from a human microbiome [PDF]
Scientific Reports, 2021 N-Acetylneuraminic acid is the most abundant sialic acid (SA) in humans and is expressed as the terminal sugar on intestinal mucus glycans. Several pathogenic bacteria harvest and display host SA on their own surfaces to evade Siglec-mediated host ...
Zhen Han +6 more
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