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Recent advances on N-acetylneuraminic acid: Physiological roles, applications, and biosynthesis [PDF]

Synthetic and Systems Biotechnology, 2023
N-Acetylneuraminic acid (Neu5Ac), the most common type of Sia, generally acts as the terminal sugar in cell surface glycans, glycoconjugates, oligosaccharides, lipo-oligosaccharides, and polysaccharides, thus exerting numerous physiological functions ...
Mingli Zhao, Yingying Zhu, Hao Wang, Wenli Zhang, Wanmeng Mu   +4 more
doaj   +3 more sources

Titrating bacterial growth and chemical biosynthesis for efficient N-acetylglucosamine and N-acetylneuraminic acid bioproduction [PDF]

Nature Communications, 2020
An imbalance between cell growth and bioproduction of engineered microbes often reduces production efficiency. Here, the authors report genetic code expansion-based cell growth and biosynthesis balance engineering to achieve high levels production of N ...
Rongzhen Tian, Yanfeng Liu, Yanting Cao, Zhongjie Zhang, Jianghua Li, Long Liu, Guocheng Du, Jian Chen   +7 more
doaj   +3 more sources

Identification of an N-acetylneuraminic acid-presenting bacteria isolated from a human microbiome [PDF]

Scientific Reports, 2021
N-Acetylneuraminic acid is the most abundant sialic acid (SA) in humans and is expressed as the terminal sugar on intestinal mucus glycans. Several pathogenic bacteria harvest and display host SA on their own surfaces to evade Siglec-mediated host ...
Zhen Han, Peter S. Thuy-Boun, Wayne Pfeiffer, Vincent F. Vartabedian, Ali Torkamani, John R. Teijaro, Dennis W. Wolan   +6 more
doaj   +3 more sources

Characterization of a novel N-acetylneuraminic acid lyase favoring industrial N-acetylneuraminic acid synthesis. [PDF]

Sci Rep, 2015
N-Acetylneuraminic acid lyase (NAL, E.C. number 4.1.3.3) is a Class I aldolase that catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) from pyruvate and N-acetyl-D-mannosamine (ManNAc). Due to the high Neu5Ac cleavage activity in
Ji W, Sun W, Feng J, Song T, Zhang D, Ouyang P, Gu Z, Xie J.   +7 more
europepmc   +6 more sources

N-acetylneuraminic acid: A scrutinizing tool in oral squamous cell carcinoma diagnosis [PDF]

Dental Research Journal, 2017
Background: Oral cancer has one of the highest mortality rate among other malignancies. An attempt has been made to assess the genetic expression of a cell surface glycoprotein component - sialic acid released by the malignant cells which will reflect on
Suganya Rajaram, Balamurali P Danasekaran, Ramesh Venkatachalapathy, Karthikshree Vishnu Prashad, Saranya Rajaram   +4 more
doaj   +3 more sources

N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer's disease mouse model. [PDF]

Nat Commun, 2023
Obesity and aging increase Alzheimer’s disease (AD) risk. Here, using an AD mouse model and high-fat diet, we suggest that immune exhaustion links the two risk factors, and identify a metabolite that can hasten immune dysfunction and memory deficit ...
Suzzi S, Croese T, Ravid A, Gold O, Clark AR, Medina S, Kitsberg D, Adam M, Vernon KA, Kohnert E, Shapira I, Malitsky S, Itkin M, Brandis A, Mehlman T, Salame TM, Colaiuta SP, Cahalon L, Slyper M, Greka A, Habib N, Schwartz M.   +21 more
europepmc   +2 more sources

Atlantic Salmon Mucins Inhibit LuxS-Dependent A. Salmonicida AI-2 Quorum Sensing in an N-Acetylneuraminic Acid-Dependent Manner. [PDF]

Int J Mol Sci, 2022
One of the most important bacterial diseases in salmonid aquaculture is furunculosis, caused by Aeromonas salmonicida. Bacterial communication through secreted autoinducer signals, quorum sensing, takes part in the regulation of gene expression in ...
Padra JT, Loibman SO, Thorell K, Sundh H, Sundell K, Lindén SK.   +5 more
europepmc   +2 more sources

Correlation of Serum N-Acetylneuraminic Acid with the Risk of Moyamoya Disease [PDF]

Brain Sciences, 2023
N-acetylneuraminic acid (Neu5Ac) is a functional metabolite and has been demonstrated to be a risk factor for cardiovascular diseases. It is not clear whether Neu5Ac is associated with a higher risk of cerebrovascular disorders, especially moyamoya ...
Chenglong Liu, Peicong Ge, Chaofan Zeng, Xiaofan Yu, Yuanren Zhai, Wei Liu, Qiheng He, Junsheng Li, Xingju Liu, Jia Wang, Xun Ye, Qian Zhang, Rong Wang, Yan Zhang, Jizong Zhao, Dong Zhang   +15 more
doaj   +2 more sources

Degradation Kinetics and Shelf Life of N-acetylneuraminic Acid at Different pH Values. [PDF]

Molecules, 2020
The objective of this study was to investigate the stability and degradation kinetics of N-acetylneuraminic acid (Neu5Ac). The pH of the solution strongly influenced the stability of Neu5Ac, which was more stable at neutral pH and low temperatures. Here,
Zhu W, Chen X, Yuan L, Wu J, Yao J.
europepmc   +2 more sources

Many locks to one key: N-acetylneuraminic acid binding to proteins [PDF]

IUCrJ
Sialic acids play crucial roles in cell surface glycans of both eukaryotic and prokaryotic organisms, mediating various biological processes, including cell–cell interactions, development, immune response, oncogenesis and host–pathogen interactions. This
KanagaVijayan Dhanabalan, YiYang Cheng, Trung Thach, Ramaswamy Subramanian   +3 more
doaj   +2 more sources