Results 141 to 150 of about 809,751 (208)

N-Acetylneuraminic acid storage disease

Human Genetics, 1985
Increased amounts of free sialic acid were found in body fluids, leukocytes, cultured fibroblasts, and liver tissue of a four-year-old boy with mental retardation, ataxia, and clinical and radiologic findings of a mild mucopolysaccharidosis. A diagnosis of Salla disease was made though in contrast to earlier reports, recurrent upper respiratory ...
J, Baumkötter, M, Cantz, K, Mendla, W, Baumann, H, Friebolin, J, Gehler, J, Spranger   +6 more
openaire   +2 more sources

Synthesis of N-acetylneuraminic acid

Experientia, 1963
Die Synthese der N-Acetylneuraminsaure aus N-Acetylmannosamin und Oxalessigsaure und die Isolierung eines Zwischenproduktes, 2-Keto-3-deoxy-3-carboxy-5-N-acetylnonulosaminsaure wird beschrieben.
H, RINDERKNECHT, T, REBANE
openaire   +2 more sources

N-Acetylneuraminic Acid: Neoglycoproteins and Pseudopolysaccharides

Journal of Carbohydrate Chemistry, 1987
Abstract A simplified procedure for the synthesis of acetochloroneuraminic acid is described starting from the methyl ester. N-acetyl neuraminic acid α-allyl glycoside was prepared in high yield using silver salicylate as catalyst. Reductive ozonolysis of the allyl group, followed by direct reductive ami nation to protein carriers, gave immunogenic ...
Roy, René, Laferrière, Craig A., Gamian, Andrzej, Jennings, Harold J.   +3 more
openaire   +2 more sources

An efficient process for production of n-acetylneuraminic acid using n-acetylneuraminic acid aldolase

Enzyme and Microbial Technology, 1997
N-acetyl-D-neuraminic acid (Neu5Ac) aldolase (EC 4.1.3.3) has bee reported for synthesis of Neu5Ac,1-5 but there are no reports of processes which do not have significant drawbacks for large-scale operation. Here, Neu5Ac aldolase from an overexpressing recombinant strain of Escherichia coli has been used to develop an immobilized enzyme process for ...
M, Mahmoudian, D, Noble, C S, Drake, R F, Middleton, D S, Montgomery, J E, Piercey, D, Ramlakhan, M, Todd, M J, Dawson   +8 more
openaire   +2 more sources

The biosynthesis of N-acetylneuraminic acid

Biochemical and Biophysical Research Communications, 1961
Abstract This communication describes a new enzyme system which catalyzes the synthesis of N -acetylneuraminic acid (NANA) from N -acetylmannosamine and phosphoenolpyruvic acid in the presence of ATP. It differs from N -acetylneuraminic acid aldolase (Comb and Roseman, 1960) which catalyzes the synthesis of NANA from N ...
L, WARREN, H, FELSENFELD
openaire   +2 more sources

Synthesis of a carbocyclic analogue of N-acetylneuraminic acid (pseudo-N-acetylneuraminic acid)

Journal of the Chemical Society, Chemical Communications, 1992
A carbocyclic analogue of N-acetylneuraminic acid was synthesized from the Diels–Alder endo-adduct of furan and acrylic acid, and its ammonium salt was subjected to biological assay.
Seiichiro Ogawa, Masaru Yoshikawa, Toshiaki Taki   +2 more
openaire   +1 more source

Modular pathway engineering of key carbon‐precursor supply‐pathways for improved N‐acetylneuraminic acid production in Bacillus subtilis

Biotechnology and Bioengineering, 2018
N‐acetylneuraminic acid (NeuAc) is widely used as a nutraceutical for facilitating infant brain development, maintaining brain health, and enhancing immunity.
Xiaolong Zhang, Yanfeng Liu, Long Liu, Miao Wang, Jianghua Li, G. Du, Jian Chen   +6 more
semanticscholar   +1 more source

Enzymatic synthesis of 7-deoxy-N-acetylneuraminic acid and 7-O-methyl-N-acetylneuraminic acid

Tetrahedron: Asymmetry, 1994
Abstract 7-Deoxy- N -acetylneuraminic Acid and 7- O -methyl- N -acetylneuraminic acid were synthesized through the sialic acid aldolase-catalyzed aldol addition reactions of 4-deoxy- N -acetyl-D-mannosamine and 4- O -methyl- N -acetyl-D-mannosamine, respectively, with pyruvate. The obtained sialic acids will be used as probes for the investigation of
Randall L. Halcomb, Wolfgang Fitz, Chi-Huey Wong   +2 more
openaire   +2 more sources

Design and modularized optimization of one‐step production of N‐acetylneuraminic acid from chitin in Serratia marcescens

Biotechnology and Bioengineering, 2018
Chitin is an abundant, biorenewable, nitrogen‐rich biomass feedstock that can be potentially developed for biochemical production; however, efficient bioprocesses have yet to be established.
Q. Yan, S. Fong
semanticscholar   +1 more source

N-acetylneuraminic acid and hostile mucus infertility

European Journal of Obstetrics & Gynecology and Reproductive Biology, 1987
A total of 39 samples of hostile mucus, as defined by postcoital examination, were examined for N-acetylneuraminic acid (NANA) deficiency, as measured by the enzymatic addition of NANA, spermatozoal penetration and immobilization. Only 56.7% of the mucus samples were deficient in NANA and this did not correlate with spermatozoal penetration or ...
Polak B., Daunter B.
openaire   +3 more sources