COLOMINIC ACID, A POLYMER OF N-ACETYLNEURAMINIC ACID [PDF]
The Journal of Experimental Medicine, 1958 All acidic carbohydrate has been isolated from the culture medium of the enteric microorganism E. coli K235 L+O. This substance has been named colominic acid. N-acetylneuraminic acid, which has been isolated from the hydrolysate of colominic acid, is believed to be the monomer unit from which colominic acid is constituted.
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Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site [PDF]
, 2018 Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic ...
Abramson, J +20 more
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Identification and characterization of a novel, versatile sialidase from a Sphingobacterium that can hydrolyze the glycosides of any sialic acid species at neutral pH [PDF]
, 2020 Bacterial sialidases are widely used to remove sialic acid (Sia) residues from glycans. Most of them cleave the glycosides of N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) under acidic pHs; however, currently available bacterial
100673 +9 more
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Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. [PDF]
, 2019 Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Chen, Xi +2 more
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Preparation of 9-fluoro-9-deoxy-N-[2-14C]acetylneuraminic acid Activation and transfer onto asialo-α1-acid glycoprotein [PDF]
9-Fluoro-9-deoxy-N-[2-14C]acetylneuraminic acid has been prepared from 6-fluoro-6-deoxy-N-acetylmannosamine and [2-14C]pyruvic acid for the first time, using Clostridium perfringens N-acetylneuraminate pyruvate-lyase (EC 4.1.3.3).
Brossmer, R., Bünsch, A., Conradt, H.S.
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Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus. [PDF]
, 2017 Sialic acids (Sias) are important glycans displayed on the cells and tissues of many different animals and are frequent targets for binding and modification by pathogens, including influenza viruses.
Ajit Varki +10 more
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N-Acetylneuraminic Acid (NANA) in Measles Virus
Experimental Biology and Medicine, 1978 The envelope glycoproteins and glycolipids of paramyxoviruses appear to be derived from the host cell plasma membrane during viral release (1, 2). Measles envelope glycoprotein spikes effect attachment of the virion to cell surfaces, thereby initiating either he-magglutination (HA) or infection (3,4).
C. Howe, P. Dore-Duffy
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The mucin-degradation strategy of Ruminococcus gnavus:The importance of intramolecular trans-sialidases [PDF]
, 2016 We previously identified and characterized an intramolecular trans-sialidase (IT-sialidase) in the gut symbiont Ruminococcus gnavus ATCC 29149, which is associated to the ability of the strain to grow on mucins. In this work we have obtained and analyzed
Crossman, Lisa C. +6 more
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Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry [PDF]
, 2016 Differentiating the structure of isobaric glycopeptides represents a major challenge for mass spectrometry-based characterisation techniques. Here we show that the regiochemistry of the most common N-acetylneuraminic acid linkages of N-glycans can be ...
Altmann, F. +8 more
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N-Acetylneuraminic Acid Analogues
Journal of Biological Chemistry, 1971 Abstract The action of N-acetylneuraminic acid aldolase on 7- and 8-carbon analogues of N-acetylneuraminic acid has been studied. The 8-carbon analogue was slowly and reversibly cleaved by the aldolase to yield 2-acetamido-2-deoxy-d-lyxose and pyruvic acid. The 7-carbon analogue was not cleaved by the enzyme.
Maitree Suttajit +2 more
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