Human species-specific loss of CMP- N -acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Cardiovascular disease (CVD) events like heart attacks and strokes due to atherosclerotic narrowing of arteries are the commonest cause of worldwide deaths, but many first-time events occur in individuals without known risk factors.
Kunio Kawanishi +5 more
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Hydroxylation of N-acetylneuraminic Acid Influences the in vivo Tropism of N-linked Sialic Acid-Binding Adeno-Associated Viruses AAV1, AAV5, and AAV6 [PDF]
Frontiers in Medicine, 2021 Adeno-associated virus (AAV) vectors are promising candidates for gene therapy. However, a number of recent preclinical large animal studies failed to translate into the clinic. This illustrates the formidable challenge of choosing the animal models that
Estrella Lopez-Gordo +6 more
doaj +2 more sources
Serum N-Acetylneuraminic Acid Is Associated with Atrial Fibrillation and Left Atrial Enlargement [PDF]
Cardiology Research and Practice, 2020 Purpose. Recent studies have indicated that N-acetylneuraminic acid (Neu5Ac) plays a key role in severe coronary artery diseases, involving RhoA signaling pathway activation, which is critically involved in cardiac fibrosis.
Wei Hu +11 more
doaj +2 more sources
N-Acetylneuraminic acid attenuates hypercoagulation on high fat diet-induced hyperlipidemic rats [PDF]
Food & Nutrition Research, 2015 Background and objective: N-Acetylneuraminic acid (Neu5Ac), a type of sialic acid, has close links with cholesterol metabolism and is often used as a biomarker in evaluating the risk of cardiovascular diseases.
Zhang Yida +6 more
doaj +2 more sources
Detection of Neuraminidase Activity in Pseudomonas aeruginosa PAO1 [PDF]
Iranian Journal of Basic Medical Sciences, 2010 Objective(s)Some properties of neuraminidase produced by Pseudomonas aeruginosa PAO1 growth in a defined medium (BHI) were examined and evaluated for its features.Materials and MethodsThe obtained supernatant enzyme of P.
Ciamak Ghazaei +2 more
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Inactivation of CMP- N -acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2002 Hsun-Hua Chou +9 more
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Effects of Administration of N-Acetylneuraminic Acid (NANA) on Brain NANA Content and Behavior
Journal of NutriLife, 1980 B. L. Morgan, Myron Winick
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Quantitation of cytidine-5'-monophospho-N-acetylneuraminic acid in human leukocytes using LC-MS/MS: method development and validation. [PDF]
Biomed Chromatogr, 2020 Fang M +11 more
europepmc +3 more sources
Purification and characterization of the Escherichia coli Kl neuB gene product N-acetylneuraminic acid synthetase [PDF]
Glycobiology, 1997 Willie F. Vann +4 more
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Prognostic Value of Elevated Levels of Plasma N-Acetylneuraminic Acid in Patients With Heart Failure
Circulation: Heart Failure, 2021 Supplemental Digital Content is available in the text. Background: Cardiac sialylation is involved in a variety of physiological processes in the heart. Altered sialylation has been implicated in heart failure (HF) mice.
Chenze Li +23 more
semanticscholar +1 more source