Overproduction of N-Acetylneuraminic Acid (Sialic Acid) by Sialuria Fibroblasts [PDF]
Pediatric Research, 1985 Fibroblasts from the original sialuria patient are shown to contain high levels of free sialic acid, i.e., an average of 87 versus a normal average of 2 nmol/mg of protein. Gas liquid chromatography-mass spectrometry analysis confirmed that the accumulated material is N-acetylneuraminic acid.
George H. Thomas +2 more
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Synthesis of Sulfo-Sialic Acid Analogues: Potent Neuraminidase Inhibitors in Regards to Anomeric Functionality [PDF]
, 2017 The design, synthesis and application of N-acetylneuraminic acid-derived compounds bearing anomeric sulfo functional groups are described. These novel compounds, which we refer to as sulfo-sialic acid analogues, include 2-decarboxy-2-deoxy-2-sulfo-N ...
Araki, Michihiro +9 more
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Molecular Structural Analysis of Porcine CMAH-Native Ligand Complex and High Throughput Virtual Screening to Identify Novel Inhibitors [PDF]
, 2023 Porcine meat is the most consumed red meat worldwide. Pigs are also vital tools in biological and medical research. However, xenoreactivity between porcine's N-glycolylneuraminic acid (Neu5Gc) and human anti-Neu5Gc antibodies poses a significant ...
Becker, Doreen +2 more
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Sialic Acid (N-Acetylneuraminic Acid) in Human Serum
Clinical Chemistry, 1964 Abstract A simple spectrophotometric method is described for the sialic acids which utilizes the reaction with resorcinol and extraction with butyl acetate-n-butanol as a solvent. Normal values for adults, utilizing N-acetylneuraminic acid as a standard, were found to be 60 ± 10.4 mg./100 ml. Values for newborn babies averaged 40.4 ± 5.7.
J. A. Cabezas, J. Vazquez Porto
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Lipase-catalyzed acetylation of N-acetylneuraminic acid deiivative [PDF]
Bioorganic & Medicinal Chemistry Letters, 1999 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lo, Lee-Chiang +3 more
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Sialic Acid Mutarotation Is Catalyzed by the Escherichia coli β-Propeller Protein YjhT [PDF]
, 2008 The acquisition of host-derived sialic acid is an important virulence factor for some bacterial pathogens, but in vivo this sugar acid is sequestered in sialoconjugates as the {alpha}-anomer.
Leech, Andrew +6 more
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Role of sialic acid in brachyspira hyodysenteriae adhesion to pig colonic mucins [PDF]
, 2019 Infection with Brachyspira hyodysenteriae results in mucoid hemorrhagic diarrhea. This pathogen is associated with the colonic mucus layer, mainly composed of mucins. Infection regulates mucin O-glycosylation in the colon and increases mucin secretion as
Haesebrouck, Freddy +3 more
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Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli [PDF]
, 2012 NanC is an Escherichia coli outer membrane protein involved in sialic acid (Neu5Ac, i.e., N-acetylneuraminic acid) uptake. Expression of the NanC gene is induced and controlled by Neu5Ac. The transport mechanism of Neu5Ac is not known.
Eisenberg, Bob +4 more
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Investigation into the Chemical Modification of Active Site Residues of an Aldolase Enzyme [PDF]
, 2014 It has previously been demonstrated that the biological incorporation and chemical modification of cysteine residues within the active site of the aldolase N-acetylneuraminic acid lyase (NAL) can lead to active chemically modified NAL variants.
Myden, Alun J.
core
Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. [PDF]
, 2015 O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes.
Chen, Xi +8 more
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