Results 51 to 60 of about 12,276 (167)

Gas–liquid chromatographic assay of lipid-bound sialic acids: measurement of gangliosides in brain of several species

Journal of Lipid Research, 1970
A method is described for analysis of gangliosides by GLC assay of the sialic acid component. Mild acid treatment in methanol converted the latter to methyl ketoside methyl ester, which was then chromatographed as the TMS derivative.
ROBERT K. YU, ROBERT W. LEDEEN
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

The Role of the Hexosamine-Sialic Acid Metabolic Pathway Mediated by GFPT1/NANS in c-Myc-Driven Hepatocellular CarcinomaSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Hepatocellular carcinoma (HCC) frequently involves metabolic reprogramming, which promotes oncogenesis and metastasis. However, the underlying molecular mechanisms remain insufficiently explored.
Shiguan Wang, Pan Han, Ping Mi, Chunxue Wang, Miao Lu, Xinying Li, Bowen Xu, Haoran Wang, Yingchen Gao, Yanlei Hou, Xueying Tan, Jinyuan Liang, Xue Ding, Yan Zhang, Tingguo Zhang, Detian Yuan, Lei Gao, Cuijuan Zhang   +17 more
doaj   +1 more source

Abnormalities of glycosphingolipids in mucopolysaccharidosis type III B.

Journal of Lipid Research, 1984
Glycosphingolipids from brain, liver, and spleen of a patient with mucopolysaccharidosis type III B were quantitatively analyzed. Neutral glycosphingolipids containing glucosylceramide, lactosylceramide, globotriaosylceramide, globotetraosylceramide, and
A Hara, N Kitazawa, T Taketomi
doaj   +1 more source

Preferential Accumulation of 14C-N-Glycolylneuraminic Acid over 14C-N-Acetylneuraminic Acid in the Rat Brain after Tail Vein Injection. [PDF]

PLoS ONE, 2015
The two main molecular species of sialic acid existing in nature are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). Neu5Ac is abundant in mammalian brains and plays crucial roles in many neural functions.
Risa Taguchi, Akira Minami, Yukino Matsuda, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki   +6 more
doaj   +1 more source

Effect of Intramolecular Hydrogen Bonds on the Binding Efficiency of Compounds Containing Aminoalcohol‐Based Subunits in Combination with Heterocyclic Groups

European Journal of Organic Chemistry, Volume 29, Issue 29, 7 August 2026.
This study broadens our understanding of the role of intramolecular interactions in molecular recognition and highlights the importance of considering their formation when designing artificial receptors, new drugs, and related systems. Aminoalcohols represent an important class of compounds and serve as building blocks for numerous biologically active ...
Manuel Stapf, Monika Mazik
wiley   +1 more source

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

Advanced Materials Interfaces, Volume 13, Issue 13, 7 July 2026.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee, Mohammad Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +3 more
wiley   +1 more source

Metabolic Signatures and Diagnostic Strategies for Different Types of Encephalitis

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Cerebrospinal fluid metabolomics in 232 patients reveals shared and distinct metabolic disruptions across encephalitis types. Diagnostic models for viral encephalitis were developed (AUC > 0.8). Subgroup analysis of autoimmune encephalitis indicated a unique metabolic signature in GFAP antibody‐positive cases, and longitudinal analysis identified ...
Yue Cui, Haitian Nan, Zhen Wang, Daiquan Gao, Hong Ye, Yunzhou Zhang, Junjie Li, Weibi Chen, Lin Wang, Jing Zhang, Liyong Wu   +10 more
wiley   +1 more source

Bio‐Based Microfluidics With Snail Slime: A By‐Product of Agriculture Plays an Exciting Role in the Chemistry of Microfluidic Reaction Chambers

Macromolecular Rapid Communications, Volume 47, Issue 14, 20 July 2026.
Due to a broad spectrum of active ingredients, snail slime presents a variety of exciting physical properties and chemical reactivities. Especially in the role of the reduction‐ and stabilizing agent for the manufacturing of gold nanoparticles, its great potential is revealed. Utilising the proteins found in slime, Nanoparticle‐comprising hydrogels are
Andrea Koball, Jens Gaitzsch
wiley   +1 more source

Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 829-850, July/August 2026.
ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song, HyunJi Lee, Youngshik Choe, Hyeyoung Lee   +3 more
wiley   +1 more source