Results 51 to 60 of about 1,001,057 (271)

Molecular Structural Analysis of Porcine CMAH–Native Ligand Complex and High Throughput Virtual Screening to Identify Novel Inhibitors

Pathogens, 2023
Porcine meat is the most consumed red meat worldwide. Pigs are also vital tools in biological and medical research. However, xenoreactivity between porcine’s N-glycolylneuraminic acid (Neu5Gc) and human anti-Neu5Gc antibodies poses a significant ...
Oluwamayowa Joshua Ogun, Georg Thaller, Doreen Becker   +2 more
doaj   +1 more source

Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. [PDF]

, 2015
O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes.
Chen, Xi, Kenyond, Nicholas J, Li, Yanhong, Louie, Angelique Y, Muthana, Musleh M, Santra, Abhishek, Tasnima, Nova, Yu, Hai, Zeng, Jie   +8 more
core   +1 more source

Marine Bacterial Sialyltransferases

Marine Drugs, 2010
Sialyltransferases transfer N-acetylneuraminic acid (Neu5Ac) from the common donor substrate of these enzymes, cytidine 5’-monophospho-N-acetylneuraminic acid (CMP-Neu5Ac), to acceptor substrates.
Takeshi Yamamoto
doaj   +1 more source

Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid binding virulence factor from Haemophilus influenzae [PDF]

, 2006
Extracytoplasmic solute receptors (ESRs) are important components of solute uptake systems in bacteria, having been studied extensively as parts of ATP binding cassette transporters.
Kelly, D.J., Muller, A., Mulligan, C., Severi, E., Thomas, G.H., Watts, A.G., Wilkinson, A.J., Wilson, K.S.   +7 more
core   +2 more sources

Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Cardiovascular disease (CVD) events like heart attacks and strokes due to atherosclerotic narrowing of arteries are the commonest cause of worldwide deaths, but many first-time events occur in individuals without known risk factors.
K. Kawanishi, C. Dhar, Raymond Do, N. Varki, P. Gordts, A. Varki   +5 more
semanticscholar   +1 more source

Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli [PDF]

, 2012
NanC is an Escherichia coli outer membrane protein involved in sialic acid (Neu5Ac, i.e., N-acetylneuraminic acid) uptake. Expression of the NanC gene is induced and controlled by Neu5Ac. The transport mechanism of Neu5Ac is not known.
Eisenberg, Bob, Giri, Janhavi, Peneff, Caroline M., Tang, John M., Wirth, Christophe   +4 more
core   +1 more source

Preparation, characterisation and antibacterial activity evaluation of N-acetylneuraminic acid-crosslinked chitosan hydrogels

Polymer Testing, 2022
In this study, CS-NeuAc hydrogel was prepared from chitosan (CS) and N-acetylneuraminic acid (NeuAc) using cyclic freeze/thaw under 1-ethyl-3-(3-dimethylaminopropyl)-carbodiiminde/N-hydroxysuccinimide catalysis. Fourier transformed infrared spectroscopy,
Yuanfei Ge, Xiangsong Chen, Xiangqin Wang, Lixia Yuan, Jinyong Wu, Jianming Yao   +5 more
doaj   +1 more source

A New Procedure for Gangliosidic N-Acetylneuraminic Acid Analysis in Serum

The International Journal of Biological Markers, 1991
In this paper a method is presented which is suitable for the extraction, purification and analysis of serum gangliosides. The advantage in comparison with other previously published procedures is the complete extraction of sialoglycolipids without ...
R. Gornati, S. Rapelli, G. Montorfano, C. Cattaneo, B. Berra   +4 more
doaj   +1 more source

Sialic acid utilization by Cronobacter sakazakii [PDF]

, 2013
Background: The Cronobacter genus is composed of seven species, and can cause infections in all age groups. Of particular concern is C. sakazakii, as this species is strongly associated with severe and often fatal cases of necrotizing enterocolitis and ...
Forsythe, S, Hariri, S, Joseph, S, Masood, N   +3 more
core   +2 more sources

Sialic Acid (N-Acetylneuraminic Acid) in Human Serum

Clinical Chemistry, 1964
Abstract A simple spectrophotometric method is described for the sialic acids which utilizes the reaction with resorcinol and extraction with butyl acetate-n-butanol as a solvent. Normal values for adults, utilizing N-acetylneuraminic acid as a standard, were found to be 60 ± 10.4 mg./100 ml. Values for newborn babies averaged 40.4 ± 5.7.
J A, CABEZAS, J V, PORTO
openaire   +2 more sources