Results 91 to 100 of about 13,464,291 (195)

A Fully Validated LC-MS Quantitation Method for Psychoactive Compounds Found in Native South American Plant Species

Psychoactives
Psychoactive drugs are compounds that alter the function of the central nervous system, resulting in changes in perception, mood, cognition, and behavior.
Jonathan Tran, Aaron C. Elkins, Simone Vassiliadis, Noel O. I. Cogan, Simone J. Rochfort   +4 more
doaj   +1 more source

Human psychopharmacology of N,N-dimethyltryptamine

, 1996
We generated dose-response data for the endogenous and ultra-short-acting hallucinogen, N,N-dimethyltryptamine (DMT), in a cohort of experienced hallucinogen users, measuring multiple biological and psychological outcome measures.
Strassman, Rick J
core  

Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential

Herein, we describe the continuous flow synthesis and in-line extraction of N,N-dimethyltryptamine (DMT) and several of its analogues using a Fischer indole reaction, along with a larger gram scale synthesis (4.75 g) of the model compound. These products
Stevens, Christian, Vandevelde, Marthe, Stevens, Christian V., Simoens, Andreas, Dejaegere, Andreas   +4 more
core   +1 more source

Dose response and time course effects off N,N-dimethyltryptamine on dissruption of rat shuttlebox avoidance

, 1977
N,N-Dimethyltryptamine (DMT) was given (ip) in different doses (0.25, 0.5, 1.0, 2.0, 4.0, 8.0 mg/kg) in a randomized order to a group of ten rats (Fisher 344/Mai) who were trained to a high, stable base line of conditioned avoidance responding in the ...
E.A. Moja, R. J. Wyatt, J. C. Gillin, D. M. Stoff   +3 more
core   +2 more sources

Contextual and experiential aspects of the psychedelic experience predicting improvement in subjective wellbeing: results from a Norwegian internet convenience sample

Frontiers in Pharmacology
BackgroundInterest in the therapeutic effects of classical psychedelics has risen recently. However, little epidemiological knowledge exists about the use of classical psychedelics in Scandinavian countries. Additionally, there is a limited understanding
Paula Aarseth Tunstad, Tor-Morten Kvam, Tor-Morten Kvam, Malin V. Uthaug, Malin V. Uthaug, Lowan H. Stewart, Kristoffer A. A. Andersen, Cato Grønnerød   +7 more
doaj   +1 more source

Dose-response study of N,N-dimethyltryptamine in humans. I. Neuroendocrine, autonomic, and cardiovascular effects

, 1994
BACKGROUND: To begin applying basic neuropharmacological hypotheses of hallucinogenic drug actions to humans, we generated dose-response data for intravenously administered dimethyltryptamine fumarate\u27s (DMT) neuroendocrine, cardiovascular, autonomic,
Qualls, Clifford R, Strassman, Rick J
core  

Impact of CYP2D6 Polymorphisms on the Pharmacokinetics of N,N-Dimethyltryptamine and Harmine via PBPK Modeling and Simulation

Future Pharmacology
Background/Objectives: In this study, we present an analysis of ayahuasca, a psychedelic preparation containing N,N-dimethyltryptamine (DMT) and β-carbolines, such as harmine (HRM), a reversible monoamine oxidase A (MAO-A) inhibitor that enables the oral
Gabriella de Souza Gomes Ribeiro, Pieter Annaert, Frederico Severino Martins, Tania Marcourakis   +3 more
doaj   +1 more source

Dimethyltryptamine (DMT) - Molecule of the Month September 2019 [Archived version]

, 2019
This is the Molecule of the Month entry for September 2019 about dimethyltryptamine.
Paul May (4181839)
core   +1 more source

Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community

Harm Reduction Journal
Background The use of psychedelics is currently increasing in the United States. Awareness of clinical trials investigating the therapeutic applications of psychedelics may result in a record number of people who use psychedelics for the first-time. This
Daniel J. Kruger, Gina Mersereau, Ashley Sullivan, Julie Barron, Moss Herberholz, Niloufar Pouyan, Jacob S. Aday, Kevin F. Boehnke   +7 more
doaj   +1 more source

N,N-dimethyltryptamine (DMT) is neither formed nor retained in serotonin terminals in the rat brain

Mammalian brain may contain an endogenous pool of the psychedelic substance N,N-dimethyltryptamine (DMT), which may act as a co-transmitter with serotonin (5-HT).
Kolesnik, Elisabeth, Palner, Mikael; id_orcid, Poetzsch, Sandra N, Baun, Christina; id_orcid, Cumming, Paul   +4 more
core   +1 more source