Results 131 to 140 of about 10,628,077 (304)

Travelling wave ion mobility and negative ion fragmentation for the structural determination of N-linked glycans

, 2013
Travelling wave ion mobility was investigated for its ability to separate N-glycans from other compounds and for resolution of isomers. Charged glycans, exemplified by sialylated complex N-glycans released from bovine fetuin and ionised by electrospray ...
Edgeworth, Matthew, Crispin, Max, Scrivens, James H., Baruah, Kavitha, Pritchard, Laura, Sobott, Frank, Harvey, David J., Scarff, Charlotte A., Scrivens, James, Allman, Sarah, Scanlan, Christopher N.   +10 more
core   +1 more source

Lowered GnT-I Activity Decreases Complex-Type N-Glycan Amounts and Results in an Aberrant Primary Motor Neuron Structure in the Spinal Cord

Journal of Developmental Biology
The attachment of sugar to proteins and lipids is a basic modification needed for organismal survival, and perturbations in glycosylation cause severe developmental and neurological difficulties.
Cody J. Hatchett, M. Kristen Hall, Abel R. Messer, Ruth A. Schwalbe   +3 more
doaj   +1 more source

The N-glycome of human embryonic stem cells

BMC Cell Biology, 2009
Background Complex carbohydrate structures, glycans, are essential components of glycoproteins, glycolipids, and proteoglycans. While individual glycan structures including the SSEA and Tra antigens are already used to define undifferentiated human ...
Olonen Anne, Aitio Olli, Jaatinen Taina, Tiittanen Minna, Blomqvist Maria, Olsson Cia, Mikkola Milla, Heiskanen Annamari, Satomaa Tero, Helin Jari, Hiltunen Jukka, Natunen Jari, Tuuri Timo, Otonkoski Timo, Saarinen Juhani, Laine Jarmo   +15 more
doaj   +1 more source

Uncommon N-Glycan Structures in Anhydrobiotic Tardigrades

Molecular & Cellular Proteomics
We characterized the N-glycosylation profiles of anhydrobiotic tardigrades, Ramazzottius varieornatus and Hypsibius exemplaris, identifying high-mannose, paucimannose, and complex-type oligosaccharides, while hybrid-type glycans were undetectable. Notably, paucimannose-type oligosaccharides accounted for 39% of the N-glycans in R.
Hirokazu Yagi, Taiki Saito, Shih-Yun Guu, Nao Yamakawa, Shigeru Shimamura, Sachiko Kondo, Maho Yagi-Utsumi, Ken Takai, Jun-ichi Furukawa, Yann Guérardel, Kay-Hooi Khoo, Kazuharu Arakawa, Koichi Kato   +12 more
openaire   +3 more sources

Immunoglobulin A carries sulfated and O-acetylated N-glycans primarily at the tailpiece site – strategies for site-specific N-glycan identification

Frontiers in Molecular Biosciences
Sulfated N-glycans from human immunoglobulin A (IgA) were recently discovered via glycomic approaches. However, their site-specific description is still pending.
Frania J. Zuniga-Banuelos, Frania J. Zuniga-Banuelos, Greta Lemke, Greta Lemke, Marcus Hoffmann, Udo Reichl, Udo Reichl, Erdmann Rapp, Erdmann Rapp   +8 more
doaj   +1 more source

Studies on the biosynthesis of ABH and Lewis epitopes on O-glycans

, 2006
ABH and Lewis antigens are carbohydrate epitopes (glycans) found on a wide variety of cell surfaces. They are involved in many biological processes, e.g transplantation rejection, bacterial and viral adhesion, cell-cell communication and metastasis.
Jonas Löfling (19493101)
core  

MALDI mass spectrometry imaging of early- and late-stage serous ovarian cancer tissue reveals stage-specific N-glycans

, 2019
Data source: Supporting information, https://doi.org/10.1002/pmic.201800482Epithelial ovarian cancer is one of the most fatal gynecological malignancies in adult women.
Oehler, MK, Briggs, M.T., Oehler, M.K., Packer, N.H., Briggs, MT, Mittal, P., Everest-Dass, AV, Mittal, P, Ho, Y.Y., Condina, MR, Packer, NH, Everest-Dass, A.V., Hoffmann, P, Hoffmann, P., Ho, YY, Kaur, G., Condina, M.R., Kaur, G   +17 more
core   +1 more source

Increased branching and sialylation of N-linked glycans correlate with an improved pharmacokinetic profile for BAY 81–8973 compared with other full-length rFVIII products

, 2019
John M Teare,1 David S Kates,1 Anita Shah,2 Stephen Garger1 1Biological Development, Bayer US LLC Pharmaceuticals, Berkeley, CA, USA; 2Pharmacokinetics Pharmacodynamics Hematology, Bayer US LLC Pharmaceuticals, Whippany, NJ, USA Background: BAY 81 ...
Teare JM, Shah A, Kates DS, Garger S
core  

Effects of N-glycans on the structure of human IgA2

Frontiers in Molecular Biosciences
The transition of IgA antibodies into clinical development is crucial because they have the potential to create a new class of therapeutics with superior pathogen neutralization, cancer cell killing, and immunomodulation capacity compared to IgG. However, the biological role of IgA glycans in these processes needs to be better understood.
Ruocco, Valentina, Grünwald-Gruber, Clemens, Rad, Behzad, Tscheliessnig, Rupert, Hammel, Michal, Strasser, Richard   +5 more
openaire   +5 more sources

Introduction of a human- and keyboard-friendly N-glycan nomenclature

Beilstein Journal of Organic Chemistry
In the beginning was the word. But there were no words for N-glycans, at least, no simple words. Next to chemical formulas, the IUPAC code can be regarded as the best, most reliable and yet immediately comprehensible annotation of oligosaccharide ...
Friedrich Altmann, Johannes Helm, Martin Pabst, Johannes Stadlmann   +3 more
doaj   +1 more source