N-glycans - Open Access .click

Results 151 to 160 of about 10,628,077 (304)

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen +7 more
wiley +1 more source

N-glycan profiling of tissue samples to aid breast cancer subtyping

Scientific Reports
Breast cancer is a highly heterogeneous disease. Its intrinsic subtype classification for diagnosis and choice of therapy traditionally relies on the presence of characteristic receptors.
Iva Benesova +11 more
doaj +1 more source

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

Arthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source

HPLC separation of N-glycans

HPLC separation of N-glycans (fucosylated and non-fucosylated trimannosyl core of N-glycans) extracted from HEK293T cells wild-type (WT); deficient in TSTA3 protein (TSTA3KO); deficient in GMDS (GMDSKO) protein; deficient in FCSK (FCSKKO) protein treated
Skurska, Edyta
core +1 more source

Separation of N-glycans by ion chromatography

, 2020
Cilj diplomske naloge je bil izvesti literaturni pregled ionske kromatografije za uporabo separacije N-glikanov. Glikani so pomemben element v farmacevtski industriji in predstavljajo pomemben del pri načrtovanju novih bioloških zdravil in cepiv pri ...
Vidmar, Monika
core

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, Accepted Article.
Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. Immunoglobulin G (IgG) from LN patients displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay +3 more
wiley +1 more source

Separation of N-glycans using hydrophilic interactions

, 2020
V diplomskem delu, sem predstavil hidrofilno interakcijsko tekočinsko kromatografijo kot tehniko za izvedbo separacije in analize N-glikanov. N-glikani in glikani na sploh so zelo pomembna vrsta spojin v bioloških sistemih.
Kovačević, Peter
core

Glycoengineered Recombinant Alpha1‐Antitrypsin Results in Comparable In Vitro and In Vivo Activities to Human Plasma‐Derived Protein

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Alpha‐1‐antitrypsin (A1AT) is a multifunctional, clinically important, high‐value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes, graft‐versus‐host disease, cystic fibrosis, and various viral infections. Currently, the only U.S. food and drug administration‐approved treatment for
Frances Rocamora +12 more
wiley +1 more source

Real time in vivo efficacy monitoring of desialylation and perforation enhanced immunotherapy of cancer

BMEMat, EarlyView.
A multifunctional nanomedicine is designed to engineer NK cells for enhanced cancer immunotherapy through perforation and desialylation, enabling real‐time monitoring of ATP and GrB levels for precise efficacy assessment. Abstract Efficient enhanced NK cell therapy is of critical importance in the immune treatment of cancer.
Yuanjiao Yang +8 more
wiley +1 more source

Multivariate phase‐dependent optimization of bioprocesses boosts performance and quality—Why timing (of exposure) matters

Biotechnology Progress, EarlyView.
Abstract Applying a single parameter set to describe complex mammalian kinetics often is too simplistic, as it fails to capture sensitive cell‐to‐environment interactions that may be exploited to optimize production performance. To resolve this time dependency, intra‐experimental parameter shifts as part of design of dynamic experiments (DoDE) can be ...
Samuel Kienzle +7 more
wiley +1 more source

polysaccharides
animals
3. good health

glycosylation
humans
medicine

glycoproteins
chromatography, high pressure liquid
carbohydrate sequence