Results 141 to 150 of about 10,628,077 (304)

The Biological Basis and Analyses of N-Glycan Microheterogeneity

Molecular & Cellular Proteomics
N-glycosylation is an abundant and essential co/post-translational modification that is preserved across all eukaryotes. N-glycans have important functions in protein stability and protein-protein interactions. N-glycans exhibit a high degree of heterogeneity, even within an individual site on the same protein, a phenomenon that is termed ...
Trevor M. Adams, Peng Zhao, Sree Hari Seenivasan, Lance Wells   +3 more
openaire   +2 more sources

Facile removal of high mannose structures prior to extracting complex type N-glycans from de-N-glycosylated peptides retained by C18 solid phase to allow more efficient glycomic mapping

, 2014
The relative amount of high mannose structures within an N-glycomic pool differs from one source to another, but quite often it predominates over the larger size complex type structures carrying biologically important glyco-epitopes.
Lin, Chi-Hung, Khoo, Kay-Hooi, Kuo, Chu-Wei, Jarvis, Donald L   +3 more
core   +1 more source

Rapid chemical de-N-glycosylation and derivatization for liquid chromatography of immunoglobulin N-linked glycans

, 2018
Glycan analysis may result in exploitation of glycan biomarkers and evaluation of heterogeneity of glycosylation of biopharmaceuticals. For N-linked glycan analysis, we investigated alkaline hydrolysis of the asparagine glycosyl carboxamide of ...
Akihiko Kameyama, Kameyama, Akihiko, Akihiko Kameyama (2033902), Thet Tin, Wai Wai, Santha Kumara Dissanayake (5171837), Wai Wai Thet Tin, Dissanayake, Santha Kumara, Santha Kumara Dissanayake, Wai Wai Thet Tin (703002)   +8 more
core   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Generating and characterizing a comprehensive panel of CHO cells glycosylation mutants for advancing glycobiology and biotechnology research

Scientific Reports
This report describes the development and characterization of a comprehensive collection of CHO cell glycosylation mutants with significant potential for advancing glycobiology and biotechnology. EPO-Fc and trastuzumab, two model molecules, were produced
Ryan Haryadi, Kah Fai Chan, Pao Chun Lin, Yun Lei Tan, Corrine Wan, Wahyu Shahreel, Shi Jie Tay, Terry Nguyen-Khuong, Ian Walsh, Zhiwei Song   +9 more
doaj   +1 more source

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

N -Glycans of Phaeodactylum tricornutum Diatom and Functional Characterization of Its N -Acetylglucosaminyltransferase I Enzyme

, 2011
International audienceN-Glycosylation, a major co- and post-translational event in the synthesis of proteins in eukaryotes, is unknown in aquatic photosynthetic microalgae.
Bruno Saint-Jean, Baïet, Bérengère, Lerouge, Patrice, Bardor, Muriel, Carole Burel, Laurence Menu-Bouaouiche, Castel, Hélène, Louvet, Romain,, Bérengère Baïet, Mathieu-Rivet, Elodie, Marie-Christine Kiefer-Meyer, Thomas Lefebvre, Elodie Mathieu-Rivet, Aude Carlier, Patrice Lerouge, Hélène Castel, Burel, Carole, Cadoret, Jean-Paul, Muriel Bardor, Louvet, Romain, R., Romain Louvet, Kiefer-Meyer, Marie-Christine, Carlier, Aude, Lefebvre, Thomas, Jean-Paul Cadoret, Saint-Jean, Bruno, Menu-Bouaouiche, Laurence   +26 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Roles for N- and O-glycans in early mouse development.

, 2011
Glycosylation is the most abundant posttranslational protein modification. Specific glycans covalently attached to glycoproteins contribute to their functions, ensuring appropriate folding, secretion, half-life, and receptor-ligand interactions [1]. Many
Pamela Stanley, Stanley, P, Williams, SA, Suzannah A. Williams   +3 more
core   +1 more source