Results 151 to 160 of about 4,874 (195)

P. falciparum EBA-181 ligand - searching for the receptor on human erythrocytes. [PDF]

Parasitol Res
Jodłowska M, Burzyńska P, Zerka A, Jaśkiewicz E.   +3 more
europepmc   +1 more source

Robustness Evaluation of a Legacy N-Glycan Profiling Method for a Therapeutic Antibody Under ICH Q14 Lifecycle Principles. [PDF]

Antibodies (Basel)
Hsieh MC, Li CR, Velardo MA, Zhang J, Parekh BS.   +4 more
europepmc   +1 more source

Enhanced ADCC Activity of a C-Terminal Lysine Variant of an IgG₁ Antibody Driven by N-Linked MAN5 Glycan Using a Reporter Gene Assay. [PDF]

Antibodies (Basel)
Hsieh MC, Dorofejeva K, Zhang J, Vy DL, Qian J, Matathia AM, Blanc T, Li CR, Parekh BS.   +8 more
europepmc   +1 more source

Sialic acids in cancer biology and immunity-recent advancements. [PDF]

J Biol Chem
van Vliet SJ, van Kooyk Y.
europepmc   +1 more source

Endocytosis of sialic acid Neu5Gc and elevated p53 contributes to preimplantation embryonic arrest during in vitro fertilization. [PDF]

J Biol Chem
Yuan X, Wu Y, Zhang Y, Yao B, Zhang L, Liu Z, Ma Q, Ma F.   +7 more
europepmc   +1 more source

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Current views on N-glycolylneuraminic acid in therapeutic recombinant proteins

Trends in Pharmacological Sciences, 2021
The incorporation of the non-human N-glycolylneuraminic acid (Neu5Gc) in therapeutic recombinant proteins raises clinical concerns due to its immunogenic potential and the high prevalence of pre-existing anti-Neu5Gc antibodies in humans. The scientific literature is ambiguous regarding the actual impact of Neu5Gc-containing biotherapeutics as no severe
Renato Mastrangeli, Maria Concetta Audino, Wolf Palinsky, Hervé Broly, Horst Bierau   +4 more
openaire   +2 more sources

N-Glycolylneuraminic acid in human tumours.

Biochimie, 2002
N-Glycolylneuraminic acid (Neu5Gc) is an abundant sialic acid, occurring in the glycoconjugates of most deuterostome animals. Homo sapiens is a notable exception, since Neu5Gc is effectively absent from normal human tissues. This is due to a deletion in the human gene coding for CMP-Neu5Ac hydroxylase, the enzyme usually responsible for Neu5Gc ...
Y N, Malykh, R, Schauer, L, Shaw
openaire   +2 more sources

N-Glycolylneuraminic acid specific lectin from Pilaglobosa snail

Biochemical and Biophysical Research Communications, 1991
A N-glycolylneuraminic acid-specific lectin (PAL) has been purified from an albumin gland extract of the apple snail, Pila globosa. Purification is conducted on a bovine submaxillary mucin-Sepharose 4B affinity matrix followed by gel filtration on a Sepharose 6B column. The lectin agglutinates rabbit erythrocytes.
S, Swarnakar, P S, Chowdhury, M, Sarkar
openaire   +2 more sources

Anti‐N‐glycolylneuraminic acid antibodies identified in healthy human serum

Xenotransplantation, 2002
Abstract: The first and major clinical obstacle in xenotransplantation is antibody‐mediated hyperacute rejection. Although human natural antibodies against Galα1,3Gal (Gal) antigens, which are common on porcine cells and organs, have been identified to play a major role in hyperacute rejection, other natural antibodies against non‐Gal epitopes may be ...
Alex, Zhu, Rosa, Hurst
openaire   +2 more sources

Microwave-assisted synthesis of N-glycolylneuraminic acid derivatives

Tetrahedron Letters, 2013
Abstract A rapid, efficient and scalable synthesis of biologically-relevant N-glycolylneuraminic acid derivatives from the natural N-acetyl (Neu5Ac) precursors has been developed. Microwave irradiation provides accelerated de-N-acetylation compared to more traditional methods, with optimised NaOH-promoted de-N-acetylation in only 15 min. The prepared
Chopra, Pradeep, Madge, Paul D, Thomson, Robin J, Grice, I Darren, von Itzstein, Mark   +4 more
openaire   +2 more sources