Results 41 to 50 of about 3,818 (198)
Frontiers in Immunology, 2022 Background Triple knockout (TKO) donor pigs lacking alpha-1,3-galactose (Gal), N-glycolylneuraminic acid (Neu5Gc), and Sd(a) expressions were developed to improve the clinical success of xenotransplantation.
Haneulnari Lee +5 more
semanticscholar +1 more source
Pathogens, 2023 The sugar molecule N-glycolylneuraminic acid (Neu5Gc) is one of the most common sialic acids discovered in mammals. Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) catalyses the conversion of N-acetylneuraminic acid (Neu5Ac) to Neu5Gc ...
Oluwamayowa Joshua Ogun +3 more
doaj +1 more source
Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen [PDF]
, 2014 Xenograft rejection of pigs organs with an engineered mutation in the GGTA-1 gene (GTKO) remains a predominantly antibody mediated process which is directed to a variety of non-Gal protein and carbohydrate antigens.
Byrne, GW +4 more
core +2 more sources
Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. [PDF]
PLoS Pathogens, 2018 While infectious agents have typical host preferences, the noninvasive enteric bacterium Vibrio cholerae is remarkable for its ability to survive in many environments, yet cause diarrheal disease (cholera) only in humans. One key V.
Frederico Alisson-Silva +10 more
doaj +1 more source
Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes [PDF]
, 2015 Background Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4GalNT2 glycosyltransferase may also synthesize xenoantigens.
Adams, A.B. +9 more
core +1 more source
Immune Response Modulation by Tumor-Secreted Glycosphingolipids [PDF]
, 2014 Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) arenow recognized as having critical effects on cellular physiology, including proliferation, differentiation, viraltransformation and ontogenesis.
Cely, Ingrid +3 more
core +1 more source
Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus. [PDF]
, 2017 Sialic acids (Sias) are important glycans displayed on the cells and tissues of many different animals and are frequent targets for binding and modification by pathogens, including influenza viruses.
Ajit Varki +10 more
core +3 more sources
Zagazig Veterinary Journal, 2022 The ultimate goal of cancer science is to learn how to select a cancer cell surface. Glycans in cancer cells are frequently at varying quantities or have fundamentally various structures than those seen in normal cells.
Dina M. M. AlSadek, H. Badr, Hafiz Ahmed
semanticscholar +1 more source
Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate? [PDF]
, 2017 Cardiac xenotransplantation (CXTx) is a promising solution to the chronic shortage of donor hearts. Recent advancements in immune suppression have greatly improved the survival of heterotopic CXTx, now extended beyond 2 years, and life-supporting kidney ...
Byrne, GW, McGregor, CGA
core +1 more source
N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens [PDF]
, 2015 BACKGROUND: The temporary or long-term xenotransplantation of pig organs into people would save thousands of lives each year if not for the robust human antibody response to pig carbohydrates.
Bern, Marshall +7 more
core +1 more source