Results 71 to 80 of about 3,818 (198)

Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates. [PDF]

, 2019
Dietary habits have been associated with alterations of the human gut resident microorganisms contributing to obesity, diabetes and cancer1. In Western diets, red meat is a frequently eaten food2, but long-term consumption has been associated with ...
Alisson-Silva, Frederico, Chang, Geoffrey, Chuzel, Léa, Diaz, Sandra L, Ganatra, Mehul B, Huang, Jianbo, Martino, Cameron, Rees, Steven D, Secrest, Patrick, Siegel, Dionicio, Taron, Christopher H, Varki, Ajit, Zaramela, Livia S, Zengler, Karsten, Zuñiga, Cristal   +14 more
core  

Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation [PDF]

, 2016
PURPOSE: Pigs expressing neither galactose-α1,3-galactose (Gal) nor N-glycolylneuraminic acid (NeuGc) take xenotransplantation one step closer to the clinic. Our aims were (1) to document the lack of NeuGc expression on corneas and aortas and cultured
Ayares, David, Cooper, David K. C., Ekser, Burcin, Hara, Hidetaka, Lee, Whayoung, Long, Cassandra, Miyagawa, Yuko, Ramsoondar, Jagdeece, Tector, A. Joseph, Tector, Alfred, Walters, Eric   +10 more
core   +1 more source

Potential Effects of Three Forms of Sialic Acid on Intestinal Health in Obese Mice Fed With a High‐Fat Diet

Food Frontiers, Volume 6, Issue 6, Page 3090-3107, November 2025.
A high‐fat diet impairs intestinal health by disrupting the mucus layer, widening epithelial gaps, triggering inflammation, and causing microbial dysbiosis, ultimately leading to obesity and metabolic disorders. Sialic acid interventionsparticularly bound forms (3ʹ‐SL and EBN)outperform free Neu5Ac in restoring microbial balance, alleviating ...
Xinyue Wang, Wei Zhang, Xinyuan Huang, Linlin Zhou, Xinning Zhao, Hanying Zheng, Xudan Shen, Xinyi Wang, Lili Pan, Yahui Li, Hongwei Li   +10 more
wiley   +1 more source

Involvement of a Non-Human Sialic Acid in Human Cancer

Frontiers in Oncology, 2014
Sialic acids are common monosaccharides that are widely expressed as outer terminal units on all vertebrate cell surfaces, and play fundamental roles in cell-cell and cell-microenvironment interactions.
Annie eSamraj, Heinz eLäubli, Nissi eVarki, Ajit eVarki   +3 more
doaj   +1 more source

Reduced binding of human antibodies to cells from GGTA1/CMAH KO pigs [PDF]

, 2014
Xenotransplantation using genetically modified pig organs could solve the donor organ shortage problem. Two inactivated genes that make humans unique from pigs are GGTA1 and CMAH, the products of which produce the carbohydrate epitopes, aGal and Neu5Gc ...
Burlak, C., Estrada, J., Li, P., Lutz, A. J., Paris, L. L., Sidner, R. A., Tector, A. J., Tector, M.   +7 more
core   +1 more source

Revolutionizing Heart Valve Therapy: A Translational Framework for Combining Decellularized Scaffolds With Genetic Modification

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 113, Issue 11, November 2025.
ABSTRACT Valvular heart disease (VHD) represents a significant global health challenge, affecting over 2.5% of the population and disproportionately impacting older adults due to age‐related degenerative processes. Current treatment options—mechanical and bioprosthetic valves—both present substantial limitations that impact patient quality of life and ...
Nikolaos P. Tzavellas, Natalia Atzemoglou, Efstathios L. Pavlidis, Alkinoos Nikolis, Georgios S. Markopoulos, Konstantinos I. Tsamis, Dimitrios Peschos, Yannis V. Simos, Lampros Lakkas   +8 more
wiley   +1 more source

A Glycoproteome Data Mining Strategy for Characterizing Structural Features of Altered Glycans with Thymic Involution

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This study presents a comprehensive data mining strategy for in‐depth extraction of overall and altered glycan features from structural and site‐specific glycoproteome data across various biomedical samples. The strategy enables the uncovery of four major altered glycan features associated with thymic involution and reveals their coordinated ...
Zhida Zhang, Yongqi Wu, Ke Hou, Yiwen Zhang, Lin Chen, Muyao Yang, Zhehui Jin, Yongchao Xu, Yingjie Zhang, Yinli Cai, Jiayu Zhao, Shisheng Sun   +11 more
wiley   +1 more source

Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs

Frontiers in Immunology, 2018
Sialic acids, a group of acidic sugars abundantly expressed in the tissues of deuterostome animals but rarely found in microbes, serve as a “signature of self” for these animals. Cognate sensors for sialic acids include Siglecs, a family of transmembrane
Takashi Angata
doaj   +1 more source

An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native Pigs

Vaccines, 2022
Pigs are promising donors of biological materials for xenotransplantation; however, cell surface carbohydrate antigens, including galactose-alpha-1,3-galactose (α-Gal), N-glycolylneuraminic acid (Neu5Gc), and Sd blood group antigens, play a significant ...
Seungwon Yoon, Seulgi Lee, Chungyu Park, Hyunyong Choi, Minwoo Yoo, Sang Chul Lee, Cheol-Ho Hyun, Nameun Kim, Taeyoung Kang, Eugene Son, Mrinmoy Ghosh, Young-Ok Son, Chang-Gi Hur   +12 more
doaj   +1 more source

Developments in Ion Exchange Chromatography–Mass Spectrometry for the Characterization of Intact Proteins and Proteoforms

Journal of Separation Science, Volume 48, Issue 9, September 2025.
ABSTRACT Ion exchange chromatography (IEC) hyphenated to mass spectrometry (MS) is a powerful non‐denaturing technique used for analyzing protein charge heterogeneity (including posttranslational modifications such as deamidation, phosphorylation, and sialylation), as well as for characterizing complex protein mixtures. This review provides an overview
Ziran Zhai, Thomas Holmark, Lars Jasperse, Andrea F. G. Gargano   +3 more
wiley   +1 more source