GlypNirO: An automated workflow for quantitative N- and O-linked glycoproteomic data analysis
Beilstein Journal of Organic Chemistry, 2020 Mass spectrometry glycoproteomics is rapidly maturing, allowing unprecedented insights into the diversity and functions of protein glycosylation. However, quantitative glycoproteomics remains challenging.
Toan K. Phung +2 more
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Human plasma protein N-glycosylation [PDF]
Glycoconjugate Journal, 2015 Glycosylation is the most abundant and complex protein modification, and can have a profound structural and functional effect on the conjugate. The oligosaccharide fraction is recognized to be involved in multiple biological processes, and to affect proteins physical properties, and has consequentially been labeled a critical quality attribute of ...
Clerc, F. +5 more
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Stereoselective N-Glycosylation by Staudinger Ligation [PDF]
Organic Letters, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Yi, He +3 more
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Proteome-wide analysis of single-nucleotide variations in the N-glycosylation sequon of human genes. [PDF]
PLoS ONE, 2012 N-linked glycosylation is one of the most frequent post-translational modifications of proteins with a profound impact on their biological function.
Raja Mazumder +4 more
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Extracellular Domain N-Glycosylation Controls Human Thrombopoietin Receptor Cell Surface Levels
Frontiers in Endocrinology, 2011 The thrombopoietin receptor (TpoR) is a type I transmembrane protein that mediates the signaling functions of thrombopoietin (Tpo) in regulating megakaryocyte differentiation, platelet formation and hematopoietic stem cell renewal.
Roxana I. Albu +1 more
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Serum Protein N-Glycosylation Signatures of Neuroblastoma [PDF]
Frontiers in Oncology, 2021 BackgroundNeuroblastoma is the most common extracranial childhood solid tumor which accounts for 10% of the malignancies and 15% of the cancer fatalities in children. N-glycosylation is one of the most frequent post-translation protein modification playing a vital role in numerous cancers. N-glycosylation changes in neuroblastoma patient serum have not
Wenjun Qin +5 more
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Variation of the serum N‐glycosylation during the pregnancy of a MPI‐CDG patient
JIMD Reports, 2021 For the first time the glycosylation of a patient with a MPI‐CDG during pregnancy is monitored. MPI‐CDG, is characterised by a deficiency in mannose‐6‐phosphate isomerase (MPI) leading to a reduced pool of glycosylation precursors, impairing the ...
Elodie Lebredonchel +4 more
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N-glycosylation requirements in neuromuscular synaptogenesis [PDF]
Development, 2013 Neural development requires N-glycosylation regulation of intercellular signaling, but the requirements in synaptogenesis have not been well tested. All complex and hybrid N-glycosylation requires MGAT1 (UDP-GlcNAc:α-3-D-mannoside-β1,2-N-acetylglucosaminyl-transferase I) function, and Mgat1 nulls are the most compromised N-glycosylation condition that ...
William, Parkinson +3 more
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N-glycosylation is required for secretion and enzymatic activity of human hyaluronidase1
FEBS Open Bio, 2014 Hyaluronidase1 (HYAL1) is a hydrolytic enzyme that degrades hyaluronic acid (HA) and has three predicted N-glycosylation sites at Asn99, Asn216, and Asn350. In this report, we show the functional significance of N-glycosylation on HYAL1 functions.
Yuki Goto +5 more
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Comparison of Fc N-Glycosylation of Pharmaceutical Products of Intravenous Immunoglobulin G. [PDF]
PLoS ONE, 2015 Intravenous immunoglobulin (IVIg) products from different pharmaceutical companies vary in composition, in part because of the selected blood donors and production process.
Willem Jan R Fokkink +5 more
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